MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 893 products of "MAPK"
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KRAS G12C inhibitor 18
CAS:KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Formula:C25H20ClFN4O3SColor and Shape:SolidMolecular weight:510.97SOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Formula:C26H29F3N4O2Color and Shape:SolidMolecular weight:486.53JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formula:C120H213F3N48O28Purity:98%Color and Shape:SolidMolecular weight:2833.28PROTAC K-Ras Degrader-2
CAS:PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.Formula:C52H60F4N8O5Color and Shape:SolidMolecular weight:953.077TAK1-IN-3
CAS:TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.Formula:C16H19N3O2SPurity:98.88%Color and Shape:SolidMolecular weight:317.41S6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Formula:C16H17BrN6OPurity:99.99%Color and Shape:SolidMolecular weight:389.25Enniatin B1
CAS:Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.Formula:C34H59N3O9Purity:98%Color and Shape:SolidMolecular weight:653.858LC-2
CAS:LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is aFormula:C59H71ClFN11O7SPurity:98%Color and Shape:SolidMolecular weight:1132.78Anti-ERK2 Antibody (5V598)
Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.Color and Shape:Odour LiquidRAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Formula:C27H28ClF4N5O2Purity:98.43%Color and Shape:SolidMolecular weight:565.99Anti-ERK2 Antibody (4F551)
Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.Color and Shape:Odour LiquidAnti-ERK2 Antibody (9C922)
Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.Color and Shape:Odour LiquidTunlametinib
CAS:Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.Formula:C16H12F2IN3O3SPurity:98.72%Color and Shape:SolidMolecular weight:491.25Enniatin B
CAS:Enniatins B decreases the activation of ERK (p44/p42).Formula:C33H57N3O9Purity:98%Color and Shape:SolidMolecular weight:639.831PD0325901-O-C2-dioxolane
CAS:The main body of PD0325901-O-C2-dioxolane is PD0325901, a non-ATP-competitive MEK1/2 inhibitor, with anticancer effects of decreasing ERK phosphorylation.Formula:C18H16F3IN2O4Color and Shape:SolidMolecular weight:508.23CE3F4 analog 1
CAS:CE3F4 analog 1 is an analogue of CE3F4.Formula:C11H9Br3FNOColor and Shape:SolidMolecular weight:429.909TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Formula:C11H17BrN2Purity:99.84%Color and Shape:SolidMolecular weight:257.17Ref: TM-T9776
5mg44.00€10mg62.00€25mg90.00€50mg170.00€100mg268.00€200mg403.00€500mg660.00€1mL*10mM (DMSO)48.00€JH295
CAS:JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.Formula:C18H16N4O2Color and Shape:SolidMolecular weight:320.352MLK-IN-1
CAS:MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.Formula:C23H20N4O3SPurity:99.74%Color and Shape:SolidMolecular weight:432.5Ref: TM-T39102
1mg54.00€5mg114.00€10mg178.00€25mg394.00€50mg620.00€100mg982.00€1mL*10mM (DMSO)126.00€Cephradine (Standard)
CAS:Cephradine (Standard) is the standard substance of Cephradine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Formula:C16H19N3O4SMolecular weight:349.40
