MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
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S6K1-IN-DG2
CAS:<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Formula:C16H17BrN6OPurity:99.25%Color and Shape:SolidMolecular weight:389.25R1487
CAS:<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Formula:C19H18F2N4O3Purity:99.77%Color and Shape:SolidMolecular weight:388.37Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01GNE-495
CAS:<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Formula:C22H20FN5O2Purity:99.22% - 99.57%Color and Shape:SolidMolecular weight:405.42TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formula:C20H12F3N3Purity:99.55% - 99.94%Color and Shape:SolidMolecular weight:351.32A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formula:C22H24Cl2N4OPurity:94.66%Color and Shape:SolidMolecular weight:431.36NG25
CAS:<p>NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.</p>Formula:C29H30F3N5O2Purity:98.32% - ≥95%Color and Shape:SolidMolecular weight:537.58PROTAC BRAF-V600E degrader-1
CAS:<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Formula:C48H54F2N10O10SPurity:99.43%Color and Shape:SolidMolecular weight:1001.07K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.34methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:<p>methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.</p>Formula:C13H13NO5Purity:97.69%Color and Shape:SolidMolecular weight:263.25IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Formula:C20H11N3O3Purity:≥98%Color and Shape:SolidMolecular weight:341.32AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formula:C27H31N7O2Purity:97.07% - 99.75%Color and Shape:SolidMolecular weight:485.58AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23B-Raf IN 11
CAS:<p>B-Raf IN 11 is a novel selective inhibitor.</p>Formula:C17H14BrF2N3O3SPurity:99.947%Color and Shape:SolidMolecular weight:458.28JNK-IN-8
CAS:<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Formula:C29H29N7O2Purity:99.24% - >99.99%Color and Shape:SolidMolecular weight:507.59Kobe2602
CAS:<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Formula:C14H9F4N5O4SPurity:98.36% - 99.39%Color and Shape:SolidMolecular weight:419.31Belvarafenib
CAS:<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Formula:C23H16ClFN6OSPurity:98% - 99.65%Color and Shape:SolidMolecular weight:478.93Vemurafenib
CAS:<p>Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.</p>Formula:C23H18ClF2N3O3SPurity:98% - 99.65%Color and Shape:SolidMolecular weight:489.92Agerafenib
CAS:<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Formula:C24H22F3N5O5Purity:95.78% - 99.23%Color and Shape:SolidMolecular weight:517.46Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Formula:C27H32O12Purity:98.91% - 99.57%Color and Shape:SolidMolecular weight:548.54
