MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 892 products of "MAPK"
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K-Ras(G12C) inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.34TRi-1
CAS:TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.Formula:C12H9ClN2O5SPurity:97.14%Color and Shape:SolidMolecular weight:328.73Ref: TM-T5481
1mg70.00€2mg89.00€5mg137.00€10mg205.00€25mg340.00€50mg485.00€100mg700.00€1mL*10mM (DMSO)150.00€Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Formula:C23H20F3N5O2S2Purity:99.62% - >99.99%Color and Shape:SolidMolecular weight:519.56BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formula:C25H28N4O2SPurity:97.16%Color and Shape:SolidMolecular weight:448.58Ref: TM-T5418
1mg50.00€5mg105.00€10mg177.00€25mg321.00€50mg482.00€100mg710.00€200mg982.00€1mL*10mM (DMSO)116.00€ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formula:C22H25ClFN7O2Purity:99.55% - 99.76%Color and Shape:SolidMolecular weight:473.93CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formula:C22H25ClN6OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:424.93BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Formula:C13H9N5O5S2Purity:97.89% - >99.99%Color and Shape:SolidMolecular weight:379.37GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Formula:C19H23N5O4SPurity:99.51%Color and Shape:SolidMolecular weight:417.48Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Formula:C8H10NO6PPurity:97.52%Color and Shape:SolidMolecular weight:247.14Cefotetan
CAS:Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.Formula:C17H17N7O8S4Purity:95.72% - 99.38%Color and Shape:SolidMolecular weight:575.62Sotorasib
CAS:Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Formula:C30H30F2N6O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:560.594Ref: TM-T8684
1g1,359.00€1mg37.00€2mg52.00€5mg79.00€10mg126.00€25mg225.00€50mg374.00€100mg459.00€500mg1,026.00€1mL*10mM (DMSO)87.00€PF-06260933 HCl
CAS:PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.Formula:C16H15Cl3N4Color and Shape:SolidMolecular weight:369.68Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurity:98.3% - 98.81%Color and Shape:SolidMolecular weight:471.46Ref: TM-T6971
1mg54.00€2mg78.00€5mg109.00€10mg169.00€25mg311.00€50mg500.00€100mg718.00€1mL*10mM (DMSO)112.00€CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Formula:C24H15F2N3Purity:98.79%Color and Shape:SolidMolecular weight:383.39Ref: TM-T5393
1mg47.00€2mg62.00€5mg92.00€10mg152.00€25mg289.00€50mg447.00€100mg670.00€1mL*10mM (DMSO)101.00€IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purity:98.8%Color and Shape:SolidMolecular weight:377.27SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Formula:C24H28N2O9SPurity:95.65%Color and Shape:SolidMolecular weight:520.55CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formula:C16H27N5O2Purity:99.96%Color and Shape:SolidMolecular weight:321.42Compound 3344 hydrochloride
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Formula:C24H27ClN2O3Purity:99.23%Color and Shape:SolidMolecular weight:426.94Ref: TM-T9184L
1mg136.00€5mg269.00€10mg404.00€25mg665.00€50mg888.00€100mg1,243.00€1mL*10mM (DMSO)318.00€BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Formula:C22H26N6O2Purity:98.11%Color and Shape:SolidMolecular weight:406.48Ref: TM-T6789
1mg82.00€2mg114.00€5mg200.00€10mg284.00€25mg477.00€50mg692.00€100mg973.00€1mL*10mM (DMSO)200.00€SB 239063
CAS:SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4
