MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 894 products of "MAPK"
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p38α inhibitor 4
CAS:p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.Formula:C14H7F6N3OPurity:99.69%Color and Shape:SolidMolecular weight:347.215RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purity:97.84%Color and Shape:SolidMolecular weight:499.91Ref: TM-T38170
1mg87.00€5mg212.00€10mg379.00€25mg780.00€50mg1,206.00€100mg1,795.00€200mg2,422.00€1mL*10mM (DMSO)226.00€UR13870
CAS:UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.Formula:C24H16F2N4Purity:99.18% - >99.99%Color and Shape:SolidMolecular weight:398.41AKP-001
CAS:AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.Formula:C21H13ClF2N4O2Purity:99.50% - 99.92%Color and Shape:SolidMolecular weight:426.8Cot inhibitor-1
CAS:Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.Formula:C27H27Cl2FN8Purity:98.87%Color and Shape:SolidMolecular weight:553.46Ref: TM-T10865
1mg73.00€5mg152.00€10mg222.00€25mg401.00€50mg602.00€100mg887.00€200mg1,215.00€1mL*10mM (DMSO)177.00€DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formula:C16H19N3OSPurity:99.85%Color and Shape:SolidMolecular weight:301.41FGTI-2734 mesylate (1247018-19-4 free base)
CAS:FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.Formula:C27H35FN6O5S2Purity:98%Color and Shape:SolidMolecular weight:606.73RPR203494
CAS:RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.Formula:C26H29FN6O4Color and Shape:SolidMolecular weight:508.54Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFormula:C21H21F3IN3O2Purity:98.00% - 99.71%Color and Shape:SolidMolecular weight:531.31ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Formula:C18H12N6OColor and Shape:SolidMolecular weight:328.33ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Formula:C16H17N5O2Color and Shape:SolidMolecular weight:311.34TC13172
CAS:TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.Formula:C17H16N4O5SPurity:98%Color and Shape:SolidMolecular weight:388.4KRAS G12C inhibitor 21
CAS:KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.Formula:C34H30ClN3O4Color and Shape:SolidMolecular weight:580.07KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Formula:C32H39F6N7O5Purity:98%Color and Shape:SolidMolecular weight:715.69CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formula:C55H87N15O22Purity:98%Color and Shape:SolidMolecular weight:1310.37HPK1-IN-13
CAS:HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Formula:C25H24FN5O2Color and Shape:SolidMolecular weight:445.49ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Formula:C23H22FN7OSColor and Shape:SolidMolecular weight:463.53Ilaprazole sodium hydrate
CAS:Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.Formula:C19H21N4NaO4SPurity:99.2%Color and Shape:SolidMolecular weight:424.45Glecirasib
CAS:Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFormula:C31H26ClF4N7O2Purity:99.7% - >99.99%Color and Shape:SolidMolecular weight:640.03GGTI-297
CAS:GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).Formula:C26H31N3O3SColor and Shape:SolidMolecular weight:465.61KRAS G12C mutant protein inhibitor A-1
CAS:KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.Formula:C31H26ClF4N7O2Color and Shape:SolidMolecular weight:640.03ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formula:C28H32ClFN6O5Color and Shape:SolidMolecular weight:587.04MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFormula:C18H20FN3O4SPurity:98%Color and Shape:SolidMolecular weight:393.43Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFormula:C22H30O2Purity:98%Color and Shape:SolidMolecular weight:326.47(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Formula:C24H20Cl2FN5O2Purity:98.73%Color and Shape:SolidMolecular weight:500.35BI-0474
CAS:BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.Formula:C30H37N9O2SPurity:99.96%Color and Shape:SolidMolecular weight:587.74Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Formula:C21H23N7O2Purity:98%Color and Shape:SolidMolecular weight:405.45GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Formula:C24H21FIN5O3Color and Shape:SolidMolecular weight:573.36HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Formula:C30H32N8O3SColor and Shape:SolidMolecular weight:584.69RGB-1
CAS:RGB-1 is a small molecule that stabilizes the RNA G-quadruplex structure and enhances G-quadruplex-mediated RNA translation inhibition.Formula:C22H12N4O4S2Purity:98.07%Color and Shape:SolidMolecular weight:460.49K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Formula:C21H27ClN4O3Purity:98%Color and Shape:SolidMolecular weight:418.92AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Formula:C25H28FN7O2Color and Shape:SolidMolecular weight:477.53KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Formula:C24H19ClF2N4O3Purity:98%Color and Shape:SolidMolecular weight:484.88KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Formula:C34H36ClFN10O2Color and Shape:SolidMolecular weight:671.17ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Formula:C23H20ClN7O2SColor and Shape:SolidMolecular weight:493.97KRAS G12C inhibitor 30
CAS:KRAS G12C inhibitor 30 is an inhibitor of KRAS G12C and can be used to study cancer.Formula:C25H22ClFN6O3Color and Shape:SolidMolecular weight:508.93SB 203580 sulfone
CAS:SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].Formula:C21H16FN3O2SColor and Shape:SolidMolecular weight:393.43TNIK&MAP4K4-IN-1
CAS:TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in humanFormula:C25H23FN4O3Color and Shape:SolidMolecular weight:446.47pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formula:C33H32F3N5O2Purity:98%Color and Shape:SolidMolecular weight:587.63B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurity:99.31% - 99.78%Color and Shape:SolidMolecular weight:409.46AZD4747
CAS:AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.Formula:C24H22ClFN2O3Purity:99.36%Color and Shape:SolidMolecular weight:440.89Ref: TM-T79213
1mg205.00€5mg537.00€10mg858.00€25mg1,251.00€50mg1,639.00€100mg2,277.00€1mL*10mM (DMSO)520.00€ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purity:98%Color and Shape:SolidMolecular weight:586.08Pan-RAF kinase inhibitor 1
CAS:Potent Pan-RAF inhibitor 1 targets RAF/MAPK pathway, curbing RAS-mutated cancer cell growth. (Patent WO2021110141A1, compound 16B)Formula:C26H24F3N3O4Color and Shape:SolidMolecular weight:499.48Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurity:98%Color and Shape:SolidMolecular weight:430.46SOS1-IN-16
CAS:SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 ofFormula:C30H31F3N4O3Purity:98%Color and Shape:SolidMolecular weight:552.59K-Ras G12C-IN-1
CAS:K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.Formula:C22H23Cl2N3O3Color and Shape:SolidMolecular weight:448.34KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Formula:C31H38N6O3Purity:98%Color and Shape:SolidMolecular weight:542.67SKF-86002 dihydrochloride
CAS:p38 MAP kinase inhibitorFormula:C16H14Cl2FN3SPurity:98%Color and Shape:SolidMolecular weight:370.27SOS1-IN-8
CAS:SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).Formula:C24H26F3N3O4Color and Shape:SolidMolecular weight:477.48KRAS inhibitor-18
CAS:KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.Formula:C20H15ClF3N3O2SColor and Shape:SolidMolecular weight:453.87
