MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
SOS1-IN-15
CAS:<p>SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.</p>Formula:C28H27F3N6O2Purity:98.32%Color and Shape:SolidMolecular weight:536.548JNK-IN-11
CAS:<p>JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.</p>Formula:C12H11NO3S2Purity:98.82%Color and Shape:SolidMolecular weight:281.35GSK2008607
CAS:<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Formula:C31H28F3N7O3S2Purity:99.36%Color and Shape:SolidMolecular weight:667.72RAF mutant-IN-1
CAS:<p>RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).</p>Formula:C23H18Cl3FN6O2SPurity:98%Color and Shape:SolidMolecular weight:567.85ERK Inhibitor II (Negative control)
CAS:<p>ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.</p>Formula:C18H12N6OColor and Shape:SolidMolecular weight:328.33SOS1-IN-14
CAS:<p>SOS1-IN-14 是选择性的、有效的、口服具有活力的 SOS1 抑制剂 (IC50: 3.9 nM)。SOS1-IN-14 能够利用 P-糖蛋白介导的外排机制在肠道内被吸收。SOS1-IN-14 能够用于 KRAS 突变的癌症的研究，且抑瘤效果比 BI-3406 好。</p>Formula:C29H29F3N6O2Color and Shape:SolidMolecular weight:550.57p38-α MAPK-IN-1
CAS:<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Formula:C27H35N5O3Purity:99.93%Color and Shape:SolidMolecular weight:477.6AZD4747
CAS:<p>AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.</p>Formula:C24H22ClFN2O3Purity:99.36%Color and Shape:SolidMolecular weight:440.89KRAS G12C inhibitor 14
CAS:<p>KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].</p>Formula:C24H19ClF2N4O3Purity:98%Color and Shape:SolidMolecular weight:484.88SOS1-IN-4
CAS:<p>SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.</p>Formula:C24H29F2N4O2PColor and Shape:SolidMolecular weight:474.48L 731734
CAS:<p>L 731734 is a farnesyltransferase inhibitor.</p>Formula:C19H38N4O3SColor and Shape:SolidMolecular weight:402.6KRAS G12C inhibitor 30
CAS:<p>KRAS G12C inhibitor 30 is an inhibitor of KRAS G12C and can be used to study cancer.</p>Formula:C25H22ClFN6O3Color and Shape:SolidMolecular weight:508.93Pan-RAF kinase inhibitor 1
CAS:<p>Potent Pan-RAF inhibitor 1 targets RAF/MAPK pathway, curbing RAS-mutated cancer cell growth. (Patent WO2021110141A1, compound 16B)</p>Formula:C26H24F3N3O4Color and Shape:SolidMolecular weight:499.48KRAS G12C inhibitor 13
CAS:<p>KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .</p>Formula:C40H46F3N7O4Purity:98%Color and Shape:SolidMolecular weight:745.83RPR203494
CAS:<p>RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.</p>Formula:C26H29FN6O4Color and Shape:SolidMolecular weight:508.54HPK1-IN-37
CAS:<p>HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.</p>Formula:C27H35N7O4Color and Shape:SolidMolecular weight:521.61PROTAC KRAS G12C degrader-3
CAS:<p>PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].</p>Formula:C63H75ClN14O6Purity:98%Color and Shape:SolidMolecular weight:1159.81ERK1/2 inhibitor 8
CAS:<p>ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).</p>Formula:C23H20ClN7O2SColor and Shape:SolidMolecular weight:493.97KRAS G12C inhibitor 35
CAS:<p>KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).</p>Formula:C31H27ClF2N6O3Color and Shape:SolidMolecular weight:605.03CMP3a
CAS:<p>CMP3a, a NEK2 inhibitor, hinders GBM in mice and enhances radiotherapy by disrupting EZH2.</p>Formula:C28H27F3N6O2SColor and Shape:SolidMolecular weight:568.61Deltasonamide 1
CAS:<p>Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.</p>Formula:C30H39ClN6O4S2Color and Shape:SolidMolecular weight:647.25(aS)-PH-797804
CAS:<p>(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].</p>Formula:C22H19BrF2N2O3Color and Shape:SolidMolecular weight:477.3AMG-548 hydrochloride (864249-60-5 free base)
<p>AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective</p>Formula:C29H28ClN5OPurity:98%Color and Shape:SolidMolecular weight:498.02KRAS G12C inhibitor 49
CAS:<p>KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.</p>Formula:C31H31ClN6O3Color and Shape:SolidMolecular weight:571.07JNK3 inhibitor-3
CAS:<p>JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.</p>Formula:C26H25N7O2Purity:98%Color and Shape:SolidMolecular weight:467.52MEK-IN-6 hydrate
CAS:<p>MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].</p>Formula:C18H22FN3O5SPurity:98%Color and Shape:SolidMolecular weight:411.45MEK-IN-6
CAS:<p>MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making it</p>Formula:C18H20FN3O4SPurity:98%Color and Shape:SolidMolecular weight:393.43SOS1-IN-7
CAS:<p>SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).</p>Formula:C23H25F3N4O3Color and Shape:SolidMolecular weight:462.46KRas G12C inhibitor 1
CAS:<p>KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.</p>Formula:C31H38N6O3Purity:98%Color and Shape:SolidMolecular weight:542.67TNIK&MAP4K4-IN-1
CAS:<p>TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in human</p>Formula:C25H23FN4O3Color and Shape:SolidMolecular weight:446.47KRAS G12C inhibitor 34
CAS:<p>KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.</p>Formula:C32H32ClN5O3Color and Shape:SolidMolecular weight:570.08KRAS G12C inhibitor 41
CAS:<p>KRAS G12C inhibitor 41 targets a key signaling protein, potentially aiding cancer research.</p>Formula:C36H37ClFN9O2Color and Shape:SolidMolecular weight:682.19Uplarafenib
CAS:<p>Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.</p>Formula:C22H21F3N4O4SPurity:99.85%Color and Shape:SolidMolecular weight:494.49SOS1-IN-13
CAS:<p>SOS1-IN-13 inhibits SOS1 (IC50: 6.5 nM) and pERK (327 nM); potential in cancer research.</p>Formula:C21H22F3N3O2Color and Shape:SolidMolecular weight:405.41p38 Kinase inhibitor 4
CAS:<p>Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].</p>Formula:C12H9Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:282.13KRAS G12C inhibitor 5
CAS:<p>KRAS G12C inhibitor 5 is a KRas G12C inhibitor.</p>Formula:C32H37N7O2Purity:98%Color and Shape:SolidMolecular weight:551.68KRAS G12C inhibitor 21
CAS:<p>KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.</p>Formula:C34H30ClN3O4Color and Shape:SolidMolecular weight:580.07pan-KRAS-IN-4
CAS:<p>Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].</p>Formula:C36H34F2N6O3Purity:98%Color and Shape:SolidMolecular weight:636.69Ras inhibitor 134
CAS:<p>Ras inhibitor 134 can be used in studies about Ras.</p>Formula:C23H21ClFN5O3Color and Shape:SoildMolecular weight:469.9JNK3 inhibitor-1
CAS:<p>JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.</p>Formula:C21H17ClFN5O2SColor and Shape:SolidMolecular weight:457.91KRAS G12C inhibitor 51
CAS:<p>KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.</p>Formula:C33H35FN6O3Color and Shape:SolidMolecular weight:582.67SOS1-IN-8
CAS:<p>SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).</p>Formula:C24H26F3N3O4Color and Shape:SolidMolecular weight:477.48ERK1/2 inhibitor 7
CAS:<p>ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).</p>Formula:C23H22FN7OSColor and Shape:SolidMolecular weight:463.53SOS1-IN-16
CAS:<p>SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of</p>Formula:C30H31F3N4O3Purity:98%Color and Shape:SolidMolecular weight:552.59HPK1-IN-10
CAS:<p>HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.</p>Formula:C31H34N6O2Color and Shape:SolidMolecular weight:522.64SOS1/KRAS-IN-1
CAS:<p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>Formula:C24H26F3N5OPurity:98%Color and Shape:SolidMolecular weight:457.49KRAS inhibitor-18
CAS:<p>KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.</p>Formula:C20H15ClF3N3O2SColor and Shape:SolidMolecular weight:453.87GNE 220 hydrochloride
CAS:<p>GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>Formula:C25H27ClN8Color and Shape:SolidMolecular weight:474.99SKF-86002 dihydrochloride
CAS:<p>p38 MAP kinase inhibitor</p>Formula:C16H14Cl2FN3SPurity:98%Color and Shape:SolidMolecular weight:370.27K-Ras G12C-IN-1
CAS:<p>K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.</p>Formula:C22H23Cl2N3O3Color and Shape:SolidMolecular weight:448.34
