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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 881 products of "MAPK"

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  • KRAS G12C inhibitor 41
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    KRAS G12C inhibitor 41

    CAS:
    <p>KRAS G12C inhibitor 41 targets a key signaling protein, potentially aiding cancer research.</p>
    Formula:C36H37ClFN9O2
    Color and Shape:Solid
    Molecular weight:682.19

    Ref: TM-T72344

  • SOS1-IN-4
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    SOS1-IN-4

    CAS:
    <p>SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.</p>
    Formula:C24H29F2N4O2P
    Color and Shape:Solid
    Molecular weight:474.48

    Ref: TM-T63083

  • GNE 220
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    GNE 220

    CAS:
    <p>GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>
    Formula:C25H26N8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.53

    Ref: TM-T11443

  • ERK1/2 inhibitor 9
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    ERK1/2 inhibitor 9

    CAS:
    <p>ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the</p>
    Formula:C31H32ClN7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:586.08

    Ref: TM-T78190

  • HPK1-IN-12
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    HPK1-IN-12

    CAS:
    <p>HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.</p>
    Formula:C25H24FN5O2
    Color and Shape:Solid
    Molecular weight:445.49

    Ref: TM-T62628

  • ARS-1323-alkyne
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    ARS-1323-alkyne

    CAS:
    ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
    Formula:C28H27ClF2N6O3
    Purity:98.00% - 99%
    Color and Shape:Solid
    Molecular weight:569

    Ref: TM-T10374

  • B-Raf IN 16
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    B-Raf IN 16

    CAS:
    <p>B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.</p>
    Formula:C20H19N5O3S
    Purity:99.31% - 99.78%
    Color and Shape:Solid
    Molecular weight:409.46

    Ref: TM-T79830

  • K-Ras G12C-IN-2
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    K-Ras G12C-IN-2

    CAS:
    <p>K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.</p>
    Formula:C21H27ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:418.92

    Ref: TM-T11736

  • ARS-1323
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    ARS-1323

    CAS:
    <p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>
    Formula:C21H17ClF2N4O2
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:430.84

    Ref: TM-T10375

  • KRAS G12C inhibitor 40
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    KRAS G12C inhibitor 40

    CAS:
    <p>KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).</p>
    Formula:C34H36ClFN10O2
    Color and Shape:Solid
    Molecular weight:671.17

    Ref: TM-T72343

  • TH-Z827
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    TH-Z827

    CAS:
    <p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>
    Formula:C30H38N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.66

    Ref: TM-T79092

  • SHP2-IN-22
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    SHP2-IN-22

    CAS:
    <p>SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-</p>
    Formula:C23H22Cl2N8O
    Color and Shape:Solid
    Molecular weight:497.38

    Ref: TM-T78896

  • CHI-000-667
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    CHI-000-667

    CAS:
    <p>CHI-000-667 can be used in studies about Ras.</p>
    Formula:C21H16ClNO4S
    Color and Shape:Solid
    Molecular weight:413.87

    Ref: TM-T77807

  • KRAS G12C inhibitor 28
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    KRAS G12C inhibitor 28

    CAS:
    <p>KRAS G12C Inhibitor 28 is a compound that effectively inhibits the KRAS G12C mutation, exhibiting potent antitumor effects with an inhibitory concentration (</p>
    Formula:C33H36F2N5O4P
    Color and Shape:Solid
    Molecular weight:635.64

    Ref: TM-T72334

  • KRAS G12C inhibitor 49
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    KRAS G12C inhibitor 49

    CAS:
    <p>KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.</p>
    Formula:C31H31ClN6O3
    Color and Shape:Solid
    Molecular weight:571.07

    Ref: TM-T64039

  • HPK1 antagonist-1
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    HPK1 antagonist-1

    CAS:
    <p>HPK1 antagonist-1 (I-792) is an inhibitor targeting HPK1, with potential applications in cancer and immune disease research [1].</p>
    Formula:C28H29FN6O2
    Color and Shape:Solid
    Molecular weight:500.57

    Ref: TM-T79071

  • ARQ-736
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    ARQ-736

    CAS:
    <p>ARQ 736 effectively targets and inhibits BRAF, crucial in MAPK pathway, beneficial for treating melanomas and certain colon cancers.</p>
    Formula:C25H25N8Na2O8PS
    Color and Shape:Solid
    Molecular weight:674.54

    Ref: TM-T71184

  • Exarafenib
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    Exarafenib

    CAS:
    <p>Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.</p>
    Formula:C26H34F3N5O3
    Purity:98.36% - 99.84%
    Color and Shape:Solid
    Molecular weight:521.58

    Ref: TM-T63644

  • Kras4B G12D-IN-1
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    Kras4B G12D-IN-1

    CAS:
    <p>Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein expression.</p>
    Formula:C16H21ClN2O4S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:372.87

    Ref: TM-T78170

  • BI-2493
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    BI-2493

    CAS:
    <p>BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth.Cost-effective and quality-assured.</p>
    Formula:C24H27N7OS
    Purity:97.74% - 99.88%
    Color and Shape:Soild
    Molecular weight:461.58

    Ref: TM-T72061