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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 881 products of "MAPK"

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  • Cobimetinib racemate
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    Cobimetinib racemate

    CAS:
    <p>Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated</p>
    Formula:C21H21F3IN3O2
    Purity:98.00% - 99.71%
    Color and Shape:Solid
    Molecular weight:531.31

    Ref: TM-T22677

  • KRAS degrader-1
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    KRAS degrader-1

    CAS:
    <p>KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].</p>
    Formula:C55H57Br2ClFIN8O7
    Color and Shape:Solid
    Molecular weight:1283.25

    Ref: TM-T79147

  • Kras binder 12
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    Kras binder 12

    CAS:
    <p>Kras binder 12 can be used in studies about Ras.</p>
    Formula:C29H47N9O6
    Color and Shape:Soild
    Molecular weight:617.74

    Ref: TM-T77808

  • Glecirasib
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    Glecirasib

    CAS:
    <p>Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signaling</p>
    Formula:C31H26ClF4N7O2
    Purity:99.7% - >99.99%
    Color and Shape:Solid
    Molecular weight:640.03

    Ref: TM-T78651

  • Org OD 02-0
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    Org OD 02-0

    CAS:
    <p>10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activate</p>
    Formula:C22H30O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:326.47

    Ref: TM-T81598

  • MNK inhibitor 9
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    MNK inhibitor 9

    CAS:
    <p>MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.</p>
    Formula:C25H29N9O
    Color and Shape:Solid
    Molecular weight:471.56

    Ref: TM-T72752

  • DL-threo dihydrosphingosine
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    DL-threo dihydrosphingosine

    CAS:
    <p>DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.</p>
    Formula:C18H39NO2
    Color and Shape:Solid
    Molecular weight:301.51

    Ref: TM-T27189

  • KRAS G12C inhibitor 35
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    KRAS G12C inhibitor 35

    CAS:
    <p>KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).</p>
    Formula:C31H27ClF2N6O3
    Color and Shape:Solid
    Molecular weight:605.03

    Ref: TM-T72338

  • KRAS inhibitor-11
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    KRAS inhibitor-11

    <p>KRAS inhibitor-11 is a KRAS inhibitor .</p>
    Formula:C29H47N9O6
    Color and Shape:Solid
    Molecular weight:617.74

    Ref: TM-T72599

  • Inflachromene
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    Inflachromene

    CAS:
    Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.
    Formula:C21H19N3O4
    Purity:97.36% - 99.88%
    Color and Shape:Solid
    Molecular weight:377.39

    Ref: TM-T24167

  • KRAS G12C inhibitor 1R
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    KRAS G12C inhibitor 1R

    CAS:
    <p>KRAS G12C inhibitor 1R can be used in studies about Ras.</p>
    Formula:C31H36ClFN6O2
    Color and Shape:Soild
    Molecular weight:579.11

    Ref: TM-T77802

  • B-Raf IN 15
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    B-Raf IN 15

    CAS:
    <p>B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.</p>
    Formula:C19H15N3OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:333.41

    Ref: TM-T78183

  • GSK1790627
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    GSK1790627

    CAS:
    GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].
    Formula:C24H21FIN5O3
    Color and Shape:Solid
    Molecular weight:573.36

    Ref: TM-T73141

  • KRAS inhibitor-14
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    KRAS inhibitor-14

    CAS:
    <p>KRAS inhibitor-14 targets G12C (IC50: 0.249 μM) and inhibits p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancers.</p>
    Formula:C20H15Cl3FN3O2S
    Color and Shape:Solid
    Molecular weight:486.77

    Ref: TM-T63235

  • KRAS G12C inhibitor 30
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    KRAS G12C inhibitor 30

    CAS:
    <p>KRAS G12C inhibitor 30 is an inhibitor of KRAS G12C and can be used to study cancer.</p>
    Formula:C25H22ClFN6O3
    Color and Shape:Solid
    Molecular weight:508.93

    Ref: TM-T63501

  • Raf inhibitor 3
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    Raf inhibitor 3

    CAS:
    <p>Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].</p>
    Formula:C18H19FN8O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.46

    Ref: TM-T79813

  • RAF mutant-IN-1
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    RAF mutant-IN-1

    CAS:
    RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).
    Formula:C23H18Cl3FN6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:567.85

    Ref: TM-T12685

  • Pan-RAF kinase inhibitor 1
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    Pan-RAF kinase inhibitor 1

    CAS:
    <p>Potent Pan-RAF inhibitor 1 targets RAF/MAPK pathway, curbing RAS-mutated cancer cell growth. (Patent WO2021110141A1, compound 16B)</p>
    Formula:C26H24F3N3O4
    Color and Shape:Solid
    Molecular weight:499.48

    Ref: TM-T63386

  • SOS1-IN-14
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    SOS1-IN-14

    CAS:
    <p>SOS1-IN-14 是选择性的、有效的、口服具有活力的 SOS1 抑制剂 (IC50: 3.9 nM)。SOS1-IN-14 能够利用 P-糖蛋白介导的外排机制在肠道内被吸收。SOS1-IN-14 能够用于 KRAS 突变的癌症的研究，且抑瘤效果比 BI-3406 好。</p>
    Formula:C29H29F3N6O2
    Color and Shape:Solid
    Molecular weight:550.57

    Ref: TM-T63887

  • FGTI-2734
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    FGTI-2734

    CAS:
    <p>FGTI-2734, a dual FT/GGT-1 inhibitor (IC50: 250/520 nM), blocks KRAS membrane binding and curbs KRAS-driven pancreatic cancer.</p>
    Formula:C26H31FN6O2S
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:510.63

    Ref: TM-T11282