MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 897 products of "MAPK"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
SOS1-IN-6
CAS:SOS1-IN-6 (compound 33-P1) is a potent inhibitor of SOS1, acting on SOS1-G12D (IC50: 14.9 nM) and SOS1-G12V (IC50: 73.3 nM).Formula:C26H28F3N3O2Color and Shape:SolidMolecular weight:471.51HPK1-IN-21
HPK1-IN-21 is a potent, orally active HPK1 kinase inhibitor with a Ki value of 0.8 nM.Formula:C22H25ClFN5O2Color and Shape:SolidMolecular weight:445.92JD123
CAS:JD123 inhibits the activity of JNK1 and the expression of cJun (1-135). It is an ATP-competitive inhibitor specific to p38-γ MAPK and has no effect on ERK1, ERK2, p38-α, p38-β, and p38-δ.Formula:C12H11N5S2Color and Shape:SolidMolecular weight:289.379MEK1/2-IN-2
MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.Formula:C28H22ClFN6OColor and Shape:SolidMolecular weight:512.97HPK1-IN-16
CAS:HPK1-IN-16, a potent HPK1 inhibitor, useful for cancer research and treatment.Formula:C28H27FN4OColor and Shape:SolidMolecular weight:454.54ERK-IN-2
CAS:ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].Formula:C16H18ClN5O2Purity:98%Color and Shape:SolidMolecular weight:347.80HPK1-IN-31
HPK1-IN-31 inhibitor with an IC 50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy .Formula:C30H33N7O3Color and Shape:SolidMolecular weight:539.63AMG-548 dihydrochloride
AMG-548 dihydrochloride, an oral p38α inhibitor (Ki: 0.5 nM), selectively targets p38β, γ, δ, inhibits TNFα (IC50: 3 nM), and suppresses Wnt signaling.Formula:C29H29Cl2N5OColor and Shape:SolidMolecular weight:534.48MNK1 ligand 1
CAS:MNK1ligand 1 (Compound 5) is an MNK1 ligand used in the synthesis of PROTACMNK1 degrader-1.Formula:C15H17N3OSColor and Shape:SolidMolecular weight:287.38ABS-752
CAS:ABS-752 is an effective and orally active molecular glue degrader targeting GSPT1 and NEK7. It exhibits cytotoxic properties and reduces the protein expression of GSPT1, SALL4, and NEK7. ABS-752 possesses anticancer activity and shows potential for research in hepatocellular carcinoma.Formula:C14H14FN3O3Color and Shape:SolidMolecular weight:291.28ERK2 IN-1
CAS:ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.Formula:C36H34FN7O2SPurity:98%Color and Shape:SolidMolecular weight:647.76HPK1-IN-30
CAS:HPK1-IN-30 is a potent inhibitor of HPK1. HPK1-IN-30 has potential for cancer disease research.Formula:C25H23FN6Color and Shape:SolidMolecular weight:426.49ATX inhibitor 26
CAS:ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.Formula:C18H19Cl2N7O3Color and Shape:SolidMolecular weight:452.30VVD-699
CAS:VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.Formula:C25H30ClFN2O6S2Color and Shape:SolidMolecular weight:573.097ADT-1004
CAS:ADT-1004 is an inhibitor of RAS. It can be used for research involving Ras-mediated diseases.Formula:C33H36FN3O6Purity:99.04%Color and Shape:SoildMolecular weight:589.65HPK1 ligand-Linker Conjugate 1
CAS:HPK1 ligand-Linker Conjugate 1 is a synthetic target protein ligand-linker compound used in the synthesis of PROTACs, such as PROTACHPK1 Degrader-5. PROTACHPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity.Formula:C19H21N3O7SColor and Shape:SolidMolecular weight:435.45SHR2415
SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.Formula:C23H22ClN7O2Color and Shape:SolidMolecular weight:463.92HPK1-IN-55
CAS:HPK1-IN-55 (compound 19) is a selective and orally active inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of less than 0.51 nM. It exhibits exceptional kinase selectivity, being over 637 times more selective for HPK1 compared to GCK kinase and over 1022 times compared to LCK. HPK1-IN-55 possesses anti-cancer properties.Formula:C30H34N8O3Color and Shape:SolidMolecular weight:554.643KRAS G12C inhibitor 50
CAS:KRAS G12C inhibitor 50 is a KRAS G12C inhibitor (IC50: 46.7 nM).Formula:C31H34N8O2Color and Shape:SolidMolecular weight:550.65KRAS G12D inhibitor 3
CAS:KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less thanFormula:C34H31ClF3N5O2Color and Shape:SolidMolecular weight:634.09
