CymitQuimica logo
MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • KRASG12C IN-15
    Targetmol
    + Info

    KRASG12C IN-15

    CAS:
    <p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>
    Formula:C31H32FN3O2
    Color and Shape:Solid
    Molecular weight:497.603

    Ref: TM-T205541

  • KRAS G12C inhibitor 37
    Targetmol
    + Info

    KRAS G12C inhibitor 37

    CAS:
    <p>KRAS G12C inhibitor 37 targets a key signaling protein, showing promise for cancer research involving KRAS G12C.</p>
    Formula:C35H39F3N8O2
    Color and Shape:Solid
    Molecular weight:660.73

    Ref: TM-T72340

  • (rel)-AR234960
    Targetmol
    + Info

    (rel)-AR234960

    CAS:
    <p>(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.</p>
    Formula:C27H30FN5O5S
    Color and Shape:Solid
    Molecular weight:555.63

    Ref: TM-T12700

  • p38 MAPK-IN-6
    Targetmol
    + Info

    p38 MAPK-IN-6

    CAS:
    <p>p38 MAPK-IN-6 (compound c47) is an inhibitor of p38 MAPK, exhibiting a 14% inhibition rate at a concentration of 10 μM.</p>
    Formula:C16H14BrN3OS2
    Color and Shape:Solid
    Molecular weight:408.336

    Ref: TM-T204525

  • CymitQuimica logo
    Targetmol
    + Info

    JH295 hydrate

    <p>JH295 hydrate: potent, irreversible Nek2 inhibitor (IC50 = 770 nM), selective, doesn't target Cdk1, Aurora B or Plk1.</p>
    Formula:C18H18N4O3
    Color and Shape:Solid
    Molecular weight:338.36

    Ref: TM-T61061

  • JD118
    Targetmol
    + Info

    JD118

    CAS:
    <p>JD118 is an inhibitor of JNK. It effectively suppresses the activity of JNK1 and the expression of cJun (1 - 135).</p>
    Formula:C13H12N4S2
    Color and Shape:Solid
    Molecular weight:288.391

    Ref: TM-T204417

  • JNK-1-IN-5
    Targetmol
    + Info

    JNK-1-IN-5

    CAS:
    <p>JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. It effectively inhibits TGF-β-induced epithelial-mesenchymal transition and shows promise for research targeting JNK1 as an anti-pulmonary fibrosis agent.</p>
    Formula:C23H21BrN6O3
    Color and Shape:Solid
    Molecular weight:509.355

    Ref: TM-T204616

  • XMU-MP-9
    Targetmol
    + Info

    XMU-MP-9

    CAS:
    <p>XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.</p>
    Formula:C19H13ClFN3OS
    Color and Shape:Solid
    Molecular weight:385.84

    Ref: TM-T200189

  • SOS1 activator 2
    Targetmol
    + Info

    SOS1 activator 2

    CAS:
    <p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>
    Formula:C26H28ClFN6
    Color and Shape:Solid
    Molecular weight:478.992

    Ref: TM-T204838

  • p38 Kinase inhibitor 8
    Targetmol
    + Info

    p38 Kinase inhibitor 8

    CAS:
    <p>p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally active inhibitor targeting p38β and JNK2α2, with IC50 values of 6.3 nM and 53.6 nM, respectively. It has demonstrated anti-inflammatory effects in a rat model of collagen-induced arthritis.</p>
    Formula:C22H21FN6O2
    Color and Shape:Solid
    Molecular weight:420.44

    Ref: TM-T205517

  • p38α inhibitor 8
    Targetmol
    + Info

    p38α inhibitor 8

    CAS:
    <p>p38α inhibitor8 (Compound 1) demonstrates inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.21 µM and 0.202 µM, respectively.</p>
    Formula:C17H13FN6
    Color and Shape:Solid
    Molecular weight:320.324

    Ref: TM-T205633

  • p38 Kinase inhibitor 7
    Targetmol
    + Info

    p38 Kinase inhibitor 7

    CAS:
    <p>p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.</p>
    Formula:C22H25FN6O
    Color and Shape:Solid
    Molecular weight:408.472

    Ref: TM-T205102

  • Coelogin
    Targetmol
    + Info

    Coelogin

    CAS:
    <p>Coelogin is an orally effective bone-protective agent that activates ER-Erk and Akt-dependent signaling pathways, thereby stimulating osteoblast differentiation. It is utilized in osteoporosis research.</p>
    Formula:C17H16O5
    Color and Shape:Solid
    Molecular weight:300.31

    Ref: TM-T201752

  • p38 MAP Kinase-IN-1
    Targetmol
    + Info

    p38 MAP Kinase-IN-1

    CAS:
    <p>p38 MAP Kinase-IN-1 (Compound 4) is an inhibitor of p38, suitable for studies related to inflammation and autoimmune responses.</p>
    Formula:C20H19FN6O
    Color and Shape:Solid
    Molecular weight:378.403

    Ref: TM-T205449

  • JNK-IN-19
    Targetmol
    + Info

    JNK-IN-19

    CAS:
    <p>JNK-IN-19 (Compound Q8) is an inhibitor of c-Jun N-terminal kinase, utilized for the treatment and/or prevention of injuries prior to, during, or following surgery.</p>
    Formula:C22H24F3N6Na2O6P
    Color and Shape:Solid
    Molecular weight:602.41

    Ref: TM-T201426

  • (±)-Perillaldehyde
    Targetmol
    + Info

    (±)-Perillaldehyde

    CAS:
    <p>(±)-Perillaldehyde exhibits antidepressant effects in mice with stress-induced depressive-like behavior by modulating the olfactory nervous system. Additionally, it demonstrates anti-inflammatory activity by activating JNK in RAW264.7 cells and suppressing the expression of TNF-α, with an IC50 value of 171.7 μM.</p>
    Formula:C10H14O
    Color and Shape:Solid
    Molecular weight:150.22

    Ref: TM-T201464

  • RIPK2-IN-6
    Targetmol
    + Info

    RIPK2-IN-6

    CAS:
    <p>RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.</p>
    Formula:C26H21NO3
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T201822

  • Lambertellin
    Targetmol
    + Info

    Lambertellin

    CAS:
    <p>Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.</p>
    Formula:C14H8O5
    Color and Shape:Solid
    Molecular weight:256.21

    Ref: TM-T201402

  • Casein kinase 1δ-IN-27
    Targetmol
    + Info

    Casein kinase 1δ-IN-27

    CAS:
    <p>Casein kinase1δ-IN-27 (Compound 8) is an inhibitor of casein kinase 1 (CK1), effectively inhibiting CK1α, CK1δ, CK1ε, and p38α with IC50 values of 22, 16.5, 9.41, and 14.8 nM, respectively. It also suppresses DUX4 expression, with an IC50 of 10 nM.</p>
    Formula:C21H19FN6
    Color and Shape:Solid
    Molecular weight:374.414

    Ref: TM-T205417

  • JNK-IN-21
    Targetmol
    + Info

    JNK-IN-21

    CAS:
    <p>JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.</p>
    Formula:C19H16N2O2S
    Color and Shape:Solid
    Molecular weight:336.408

    Ref: TM-T204504