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MEK

MEK

MEK is a dual-specificity kinase that plays a central role in the MAPK/ERK signaling pathway by activating ERK through phosphorylation. MEK signaling is crucial for regulating cell growth, survival, and differentiation. Aberrant MEK activity has been implicated in various cancers and developmental disorders, making it an important therapeutic target. At CymitQuimica, we provide a variety of MEK inhibitors and modulators to support your research in oncology, cell signaling, and therapeutic development.

Found 72 products of "MEK"

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  • Trametinib
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    Trametinib

    CAS:
    <p>Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits &gt;180 kinases.</p>
    Formula:C26H23FIN5O4
    Purity:98% - 99.96%
    Color and Shape:Solid
    Molecular weight:615.39

    Ref: TM-T2125

  • RO4987655
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    RO4987655

    CAS:
    <p>RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).</p>
    Formula:C20H19F3IN3O5
    Purity:98.21%
    Color and Shape:Solid
    Molecular weight:565.28

    Ref: TM-T5412

  • GW284543
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    GW284543

    CAS:
    <p>GW284543 (UNC10225170) is a selective inhibitor of MEK5 .</p>
    Formula:C23H20N2O3
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:372.42

    Ref: TM-T7610

  • Trametiglue
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    Trametiglue

    CAS:
    <p>Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.</p>
    Formula:C25H24FIN6O5S
    Color and Shape:Solid
    Molecular weight:666.46

    Ref: TM-T75110

  • Avutometinib potassium
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    Avutometinib potassium

    CAS:
    <p>Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.</p>
    Formula:C21H17FKN5O5S
    Color and Shape:Solid
    Molecular weight:509.55

    Ref: TM-T68270

  • PD 334581
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    PD 334581

    CAS:
    <p>MEK1 inhibitor</p>
    Formula:C20H19F3IN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:545.3

    Ref: TM-T23129

  • MEK inhibitor
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    MEK inhibitor

    CAS:
    <p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>
    Formula:C26H26N4O2
    Purity:97.48%
    Color and Shape:Solid
    Molecular weight:426.51

    Ref: TM-T11993

  • JTP-70902
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    JTP-70902

    CAS:
    <p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>
    Formula:C24H21BrFN5O5S
    Color and Shape:Solid
    Molecular weight:590.42

    Ref: TM-T24222

  • MEK-IN-1
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    MEK-IN-1

    CAS:
    <p>MEK-IN-1 is a MEK inhibitor.</p>
    Formula:C24H20N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.44

    Ref: TM-T10675

  • MEK-IN-4
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    MEK-IN-4

    CAS:
    <p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>
    Formula:C21H18N4OS
    Purity:98.35% - 99.16%
    Color and Shape:Solid
    Molecular weight:374.46

    Ref: TM-T28012

  • (R)-PD 0325901CL
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    (R)-PD 0325901CL

    CAS:
    <p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>
    Formula:C16H14ClF2IN2O4
    Color and Shape:Solid
    Molecular weight:498.65

    Ref: TM-T72654

  • Cobimetinib racemate
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    Cobimetinib racemate

    CAS:
    <p>Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated</p>
    Formula:C21H21F3IN3O2
    Purity:98.00% - 99.71%
    Color and Shape:Solid
    Molecular weight:531.31

    Ref: TM-T22677

  • MEK-IN-6 hydrate
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    MEK-IN-6 hydrate

    CAS:
    <p>MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].</p>
    Formula:C18H22FN3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:411.45

    Ref: TM-T79048

  • MS934
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    MS934

    CAS:
    <p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>
    Formula:C52H69F3IN7O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1104.11

    Ref: TM-T79143

  • GSK1790627
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    GSK1790627

    CAS:
    <p>GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].</p>
    Formula:C24H21FIN5O3
    Color and Shape:Solid
    Molecular weight:573.36

    Ref: TM-T73141

  • Nedometinib
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    Nedometinib

    CAS:
    <p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>
    Formula:C17H16FIN4O3
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:470.24

    Ref: TM-T78209

  • CymitQuimica logo
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    MEK1/2-IN-2

    <p>MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.</p>
    Formula:C28H22ClFN6O
    Color and Shape:Solid
    Molecular weight:512.97

    Ref: TM-T63547

  • Refametinib R enantiomer
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    Refametinib R enantiomer

    CAS:
    <p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>
    Formula:C19H20F3IN2O5S
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:572.34

    Ref: TM-T12697

  • EBI-1051
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    EBI-1051

    CAS:
    <p>EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).</p>
    Formula:C18H15F2IN2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:504.22

    Ref: TM-T15193

  • G-479
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    G-479

    CAS:
    <p>G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.</p>
    Formula:C16H15FIN5O4
    Color and Shape:Solid
    Molecular weight:487.22

    Ref: TM-T71344

  • Luvometinib
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    Luvometinib

    CAS:
    <p>Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.</p>
    Formula:C26H22F2IN5O4S
    Color and Shape:Solid
    Molecular weight:665.45

    Ref: TM-T201266

  • MEK4 inhibitor-2
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    MEK4 inhibitor-2

    CAS:
    <p>MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.</p>
    Formula:C20H15FN4O3S
    Color and Shape:Solid
    Molecular weight:410.42

    Ref: TM-T62079