ERK
ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.
Found 217 products of "ERK"
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Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurity:98.31%Color and Shape:SolidMolecular weight:454.53Ref: TM-T62798
1mg130.00€5mg313.00€1mL*10mM (DMSO)341.00€10mg497.00€25mg982.00€50mg1,603.00€100mg2,592.00€ERK1/2 inhibitor 1
CAS:ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
Formula:C29H32ClN5O4Purity:98.81%Color and Shape:SolidMolecular weight:550.05Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Formula:C18H18N2O4Color and Shape:SolidMolecular weight:326.35GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purity:98%Color and Shape:SolidMolecular weight:304.38GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColor and Shape:SolidMolecular weight:462.47BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purity:98%Color and Shape:SolidMolecular weight:282.29UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Color and Shape:SolidMolecular weight:403.9VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Formula:C19H19FN2O2Color and Shape:SolidMolecular weight:326.36mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purity:99.26%Color and Shape:SolidMolecular weight:1948.31ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formula:C24H23Cl2FN4O2Color and Shape:SolidMolecular weight:489.37Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Formula:C8H16O2S2Purity:97.51%Color and Shape:Yellow To Orange LiquidMolecular weight:208.34PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Formula:C22H16F2N4O2Purity:98%Color and Shape:SolidMolecular weight:406.38Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formula:C19H19ClF2N4O3SColor and Shape:SolidMolecular weight:456.89Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColor and Shape:SolidMolecular weight:276.13(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purity:98.09%Color and Shape:SolidMolecular weight:304.38Ref: TM-T11137
1mg77.00€1mL*10mM (DMSO)153.00€5mg158.00€10mg225.00€25mg338.00€50mg472.00€100mg645.00€ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purity:99.71% - 99.95%Color and Shape:SolidMolecular weight:344.37Ref: TM-T61122
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Formula:C11H19BrCl2N2Purity:99.75%Color and Shape:SolidMolecular weight:330.092RLX-33
CAS:RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.Formula:C24H19ClN4O4Purity:99.89%Color and Shape:SolidMolecular weight:462.89ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Formula:C16H17N5O2Color and Shape:SolidMolecular weight:311.34K145 hydrochloride
CAS:K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.Formula:C18H25ClN2O3SPurity:99.8%Color and Shape:SolidMolecular weight:384.92
