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p38 MAPK

p38 MAPK

p38 MAPKs are a subgroup of MAPKs that respond to stress signals and are involved in the regulation of inflammation, cell differentiation, apoptosis, and autophagy. p38 MAPK signaling is crucial in immune responses and is implicated in various diseases, including chronic inflammatory conditions, cancer, and neurodegenerative disorders. At CymitQuimica, we provide a comprehensive range of p38 MAPK inhibitors and modulators to support your research in inflammation, stress response, and therapeutic development.

Found 129 products for "p38 MAPK".

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    p38α-IN-11

    CAS:
    p38α-IN-11 (Compound 16c) is a p38α inhibitor with a dissociation constant (KD) of 586 nM, and it is used for cervical cancer research.
    Formula:C26H30N6O2S
    Molecular weight:490.63

    Ref: TM-T215014

  • 10-Methoxy-canthin-6-one
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    10-Methoxy-canthin-6-one

    CAS:
    10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.
    Formula:C15H10N2O2
    Color and Shape:Solid
    Molecular weight:250.25

    Ref: TM-T200611

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    P2L-003

    CAS:
    P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 μM in HT-29 cells. It blocks PAR2-mediated Ca2+ mobilization without affecting signaling through PAR1, PAR4, or ATP. P2L-003 dose-dependently inhibits downstream MAPK signaling cascades, including the phosphorylation of ERK1/2 and p38, and is applicable in colon cancer research.
    Formula:C23H25ClN4O3S
    Molecular weight:472.99

    Ref: TM-T214285

  • p38 Kinase inhibitor 7
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    p38 Kinase inhibitor 7

    CAS:
    p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.
    Formula:C22H25FN6O
    Color and Shape:Solid
    Molecular weight:408.472

    Ref: TM-T205102

  • p38 MAP Kinase-IN-1
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    p38 MAP Kinase-IN-1

    CAS:
    p38 MAP Kinase-IN-1 (Compound 4) is an inhibitor of p38, suitable for studies related to inflammation and autoimmune responses.
    Formula:C20H19FN6O
    Color and Shape:Solid
    Molecular weight:378.403

    Ref: TM-T205449

  • p38-α MAPK-IN-10
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    p38-α MAPK-IN-10

    CAS:
    p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.
    Formula:C27H34Cl2N6
    Color and Shape:Solid
    Molecular weight:513.505

    Ref: TM-T205642

  • PS-166276
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    PS-166276

    CAS:
    PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.
    Formula:C20H30N8O
    Color and Shape:Solid
    Molecular weight:398.51

    Ref: TM-T201008

  • PF-03715455
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    PF-03715455

    CAS:
    PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.
    Formula:C35H34ClN7O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:700.27

    Ref: TM-T16477

  • Emprumapimod
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    Emprumapimod

    CAS:
    Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; for cardiomyopathy, acute pain.
    Formula:C24H29F2N5O3
    Purity:99.10% - >99.99%
    Color and Shape:Solid
    Molecular weight:473.52

    Ref: TM-T63067