CFTR
CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.
Found 66 products of "CFTR"
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CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49Ref: TM-T5312
2mg37.00€5mg55.00€1mL*10mM (DMSO)59.00€10mg80.00€25mg147.00€50mg215.00€100mg318.00€200mg444.00€GlyH-101
CAS:GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.Formula:C19H15Br2N3O3Purity:98.71% - 98.78%Color and Shape:SolidMolecular weight:493.15Ref: TM-T2451
1mg34.00€5mg71.00€1mL*10mM (DMSO)80.00€10mg103.00€25mg210.00€50mg354.00€100mg530.00€200mg755.00€Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49Ref: TM-T2588
1mg35.00€2mg50.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg120.00€25mg195.00€50mg288.00€100mg416.00€200mg600.00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Formula:C26H27F3N2O6Purity:98.84% - >99.99%Color and Shape:SolidMolecular weight:520.5Ref: TM-T2263
1mg38.00€2mg50.00€5mg78.00€1mL*10mM (DMSO)94.00€10mg116.00€25mg200.00€50mg324.00€100mg477.00€GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurity:99.64% - 99.91%Color and Shape:SolidMolecular weight:348.42Glibenclamide potassium
CAS:Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.Formula:C23H27ClKN3O5SColor and Shape:SolidMolecular weight:532.09IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formula:C22H15Br2N3O4Purity:98.92% - ≥95%Color and Shape:SolidMolecular weight:545.18KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormula:C19H17Cl2N3O2SPurity:98.86%Color and Shape:SolidMolecular weight:422.33Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Formula:C12H13F6N3O3Purity:99.76%Color and Shape:SolidMolecular weight:361.24Ref: TM-T9499
1mg152.00€1mL*10mM (DMSO)248.00€5mg313.00€10mg469.00€25mg750.00€50mg1,054.00€100mg1,494.00€200mg2,025.00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24Ref: TM-T1805
5mg35.00€1mL*10mM (DMSO)46.00€10mg54.00€25mg88.00€50mg117.00€100mg178.00€200mg213.00€500mg359.00€SRI-41315
CAS:SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Formula:C22H19N3O2Purity:99.87%Color and Shape:SolidMolecular weight:357.41Ref: TM-T2S1837
1mg49.00€1mL*10mM (DMSO)73.00€5mg89.00€10mg154.00€25mg250.00€50mg371.00€100mg552.00€200mg785.00€(R)-Olacaftor
CAS:(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.Formula:C29H34FN3O4SColor and Shape:SolidMolecular weight:539.66SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Formula:C24H23N3O2Purity:98.73%Color and Shape:SolidMolecular weight:385.46Ivacaftor-D9
CAS:CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.Formula:C24H19D9N2O3Color and Shape:SolidMolecular weight:401.55AF-2785
CAS:In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.Formula:C17H12Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:347.2CFTR corrector 9
CAS:CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.Formula:C16H14N2O4Purity:99.75%Color and Shape:SolidMolecular weight:298.29Ref: TM-T60653
2mg39.00€1mL*10mM (DMSO)58.00€5mg60.00€10mg96.00€25mg170.00€50mg253.00€100mg363.00€200mg510.00€Corrector C4
CAS:Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants andFormula:C21H17ClN4O2S2Purity:99.98%Color and Shape:SolidMolecular weight:456.97Galicaftor
CAS:ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).Formula:C28H21F4NO7Purity:98.84%Color and Shape:SolidMolecular weight:559.46Ref: TM-T22252
1mgTo inquire10mgTo inquire5mg192.00€1mL*10mM (DMSO)236.00€25mg625.00€50mg982.00€100mg1,639.00€Posenacaftor sodium
CAS:Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.Formula:C27H27NNaO5Color and Shape:SolidMolecular weight:468.505
