Calcium Channel

JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic

NC 1100 is a calcium channel antagonist.

SQ-31765 is a blocker of benzazepine calcium channel.

<p>TTA-A8 is an antagonist of T-type calcium channel.</p>

Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .

Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium.

(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.

McN5691 is a voltage sensitive calcium channel blocker.

cADPR, made from NAD+, boosts calcium in cells via Ryanodine receptors and TRPM2 channels.

Dopropidil: anti-angina calcium regulator with anti-ischemic properties in animal models.

Nemadipine A blocks L-type Ca2+ channels, alters C. elegans morphology, boosts TRAIL's cancer kill rate, and lowers Survivin in A549 cells.

TDN345 is a antagonist of Ca2+, for the treatment of vascular and senile dementia including Alzheimer's disease.

Ned-K blocks NAADP, reduces heart ischemia-reperfusion calcium waves.

piCRAC-1 is a powerful inhibitor of the photoinducible Ca2+ release-activated Ca2+ (CRAC) channel.

Cavα2δ1&NET-IN-2 .

AJG-049 HCl is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).

PD-151307 is used as an N-type calcium channel blocker.

MEM-1003, a calcium channel blocker, is used potentially for the treatment of bipolar disorders.

RyRs activator 3 (compound A4) serves as an insecticide highly effective against both the diamondback moths, M.

AMG-1 inhibits CRAC channels, blocks effector T cells, not regulatory ones, and reduces EAE progression.

NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.

RQ-00311651 is a novel T-type Ca2+ channel blocker. RQ-00311651 also inhibited high K-induced Ca signaling in those cells.

(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a blocker of calcium channel.

β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit.

TMB 8 blocks nAChRs (IC50: 390-480 nM), reduces Ca2+ in muscles, hinders rabbit aorta contraction at 50 μM, and inhibits PKC dose-dependently.

Sadopine is a high-affinity radioligand for DHP receptor in L-type Ca2+ channels, suitable for tissue and membrane labeling.

(R)-Lercanidipine enantiomer: antihypertensive, blocks L-type Ca2+ channels, dilates blood vessels.

PD0176078 () is a newly blocker of N-type Calcium channel.

Lidoflazine: antianginal, blocks HERG K+ & Ca channels, risks QT prolongation & arrhythmia.

Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel antagonist of vasoselective Ca2+ channel.

TTA-P2: potent CNS-penetrating T-type Ca2+ channel blocker; eliminates Cav3.1 window currents.

Leconotide is a calcium channel blocker and antihyperalgesia agent; isolated from the venom of the cone snail, Conus catus.

ML218 is an inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3).ML218 inhibits the synaptic activity of subthalamic nucleus (STN) neurons.

Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways.

IDO1-IN-19 (Compound 17) is a potent inhibitor of IDO1 and has potential for cancer disease research.

CXL-1020, a HNO prodrug, enhances heart muscle function & relaxation, aiding in heart failure research.

Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.

Cavα2δ1&NET-IN-1 .

18:0 LYSO-PE is a compound that induces an increase in [Ca2+]i and can be used as a phospholipid (PL) standard for lipid analysis by electrospray mass spectrometry (ESI-MS)/MS.

SB-237376 HCl (SB-237376 hydrochloride) is a calcium and potassium channel antagonist used in the treatment of cardiac arrhythmias.

DHP-218, a calcium channel blocker, inhibits rat aorta contractions; pA2: 9.11, IC50: 6.3 nmol/L (high K+) & 66 nmol/L (phenylephrine).

AH-1058 HCl is a lipophilic antiarrhythmic calcium channel blocker.

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.

CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities.

PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2).

<p>Terflavoxate is a novel, orally active, semisynthetic statin microtubule inhibitor commonly used in combination with capecitabine.</p>

Enecadin is a neuroprotective agent.

Fenoverine (Spasmopriv) has antispasmodic activity and can be used to study gastrointestinal spasms.

Ticolubant: Oral LTB4 antagonist, Ki=0.78 nM; blocks Ca2+ migration, IC50=6.6 nM; anti-inflammatory in mice.

Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

<p>DS16570511 is a novel, cell-permeable inhibitor targeting the mitochondrial calcium uniporter.</p>

Pelretin (BASF 43915) is a potential protein inhibitor for the study of dermatologic diseases.

Tiapamil hydrochloride (Ro 11-1781 hydrochloride) is a calcium channel blocker with antihypertensive activity used in the study of angina pectoris.

Cerebrocrast (IOS-11212) has anti-inflammatory and hypoglycemic activity, blocks human platelet activation, and is used in the study of diabetes.

GSK205 is a selective TRPV4 antagonist (IC50: 4.19 μM) for inhibiting TRPV4-mediated Ca2+ influx.

Crobenetine (BIII 890 CL) Free Base is a selective NaV channel blocker that eliminates VTD-induced [Ca2+] elevation.

SAK3 is a modulator of nAChR activity and is used to study memory deficits and Alzheimer's disease.

FPL-62129 is a calcium channel antagonist and a novel angiotensin-converting enzyme inhibitor with vasodilator activity for the study of cardiovascular disease.

Opc 8490 is a cardiotonic agent and a positive inotropic vasodilator, which prolongs the atrial action potential in a concentration-dependent manner.

<p>8-Bromo-cGMP sodium: PKG activator, eases pain, dilates vessels, reduces Ca2+ currents &amp; insulin release.</p>

<p>AZD-1305: novel anti-arrhythmic blocking IKr, Ca, Na currents; useful in arrhythmia research.</p>

<p>Diproteverine HCl is a novel calcium antagonist with antianginal properties, antispasmodic and vasoactive.</p>

<p>Sulcardine sulfate (B-87823) is a multi-ion channel blocker with antiarrhythmic activity that inhibits Na+, K+, and Ca2+ channels.</p>

O-1602 is a novel GPR55 agonist, an atypical cannabinoid associated with the central nervous system and obesity, and is a candidate compound for the treatment

<p>Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.</p>

Upacicalcet (AJT-240) is a calcium mimetic for SHPT in dialysis, reducing PTH by targeting parathyroid receptors.

<p>Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.</p>

Clopimozide (R-29764), a long-acting oral antischizophrenic, blocks calcium channels and [3H] nilandipine binding.

SERCA2a activator 1 boosts heart function by reducing phospholamban restraint and enhancing cardiac contraction-relaxation cycles.

Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting

Gallopamil blocks acid secretion (IC50: 10.9 μM), acts as antiarrhythmic, vasodilator, and is a methoxy Verapamil derivative.

R 56865 is a weak potential-operated channel inhibitor that inhibits the late sodium current in human isolated cardiomyocytes.

<p>NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.</p>

Iganidipine（NKY 722） is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.

A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonist

N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.

Piprofurol is used as a Calcium channel blocker.

Broad spectrum cation channel blocker

RO 23-6152, a new calcium antagonist, can inhibit platelet aggregation in vitro associated with occlusive coronary thrombus formation.

Mioflazine hydrochloride anhydrous is a nucleoside transport inhibitor that acts on adenosine to improve sleep.

MONIRO-1 blocks T/N-type Ca²⁺ channels: hCav2.2 (IC50: 34μM), hCav3.1 (3.3μM), hCav3.2 (1.7μM), hCav3.3 (7.2μM).

Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.

Nelutroctiv is a potent activator of cardiac troponin.

RS 5773 is a benzothiazepine derivative with antianginal effects.

Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.

Naltiazem, a calcium channel antagonist, is used potentially for the treatment of arrhythmias, hypertension and myocardial infarction.

Mioflazine suppresses nucleoside uptake. Mioflazine is an orally active nucleoside transport inhibitor. It has the potential for sleep disorders treatment.

Coelenterazine H, a Ca2+ sensitive synthetic derivative, is a luminescent biomolecule used to measure Ca2+ changes.

HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein

8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38.

Cavα2δ1&NET-IN-3 (example 216) is an inhibitor targeting both the α2δ subunit of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET).

NKY-722 (HCl), also known as Iganidipine, is a calcium channel blocker potentially for the treatment of glaucoma.

A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.

(S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.

<p>5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE).</p>

ATI-22-107 is a positive cardiac inotropic agent which may affect myocyte calcium cycling and contractility.

<p>Cav 3.2 Inhibitor 4 (Compound 21) is a selective and potent inhibitor of the T-type calcium channel (Ca v 3.2), demonstrating peripheral restriction with an</p>

TROX-1 is the activation state-dependent Cav2 channel antagonist.

BBT has anti-hyperglycemic activity, protecting beta cells from cytokine or streptozotocin-induced cell death, and restoring beta cell function.