Calcium Channel

<p>ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.</p>

<p>Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.</p>

<p>14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy.</p>

<p>Cinacalcet metabolite M4 (Rarechem AL BW 1078) is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.</p>

<p>Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.</p>

<p>N6-(2-Hydroxyethyl)adenosine is a sedative, Ca2+ antagonist, and anti-inflammatory, affecting brain and heart blood flow.</p>

<p>Amlodipine maleate (Amvaz) is an oral dihydropyridine calcium blocker for hypertension and cancer studies.</p>

<p>Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity used in the study of hypertension.</p>

Diltiazem (CRD 401 free base) is an orally available L-type Ca2+ channel blocker with antihypertensive, antiarrhythmic, and cardioprotective properties that prevent post-reperfusion myocardial injury, angina pectoris, and cardiovascular-related diseases.

<p>Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels</p>

Apinocaltamide (ACT-709478) is an orally available and selective T-type calcium channel blocker that cross BBB for Cav3.1, Cav3.2, and Cav3.3,epilepsy.

<p>N-Methyl-L-leucine ((S)-4-Methyl-2-(methylamino)pentanoic acid) is a novel calcium channel antagonist used in pain research.</p>

Bupivacaine-d9 is a deuterated compound of Bupivacaine. Bupivacaine has a CAS number of 38396-39-3. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.

<p>Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic gabapentin, offering sustained dose-proportional exposure and predictable bioavailability.</p>

<p>Applications 4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications 1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Amlodipine besilate impurity G is a Calcium Channel antagonist with potential application in the study of neurological diseases and is an impurity in the</p>

<p>Cinepazide: a vasodilator targeting adenosine A2 receptors, treats various vascular diseases.</p>

<p>Amlodipine hydrochloride is a salt of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.</p>

Maresin 1 is biosynthesized by macrophages (MΦ) and possesses significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice.