PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 165 products of "PDE"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Formula:C22H29N3O4Purity:98%Color and Shape:SolidMolecular weight:399.48PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Formula:C22H18ClF2N3O2SPurity:98%Color and Shape:SolidMolecular weight:461.91Propentofylline
CAS:<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Formula:C15H22N4O3Purity:99.76% - 99.86%Color and Shape:Off-White SolidMolecular weight:306.36Deltasonamide 2
CAS:<p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Formula:C30H39ClN6O4S2Purity:98%Color and Shape:SolidMolecular weight:647.25Deltasonamide 2 (TFA)
CAS:<p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Formula:C32H40ClF3N6O6S2Purity:98%Color and Shape:SolidMolecular weight:761.28PDE9-IN-1
CAS:<p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>Formula:C17H23FN6O2Purity:99.86%Color and Shape:SolidMolecular weight:362.4Tilivapram
CAS:<p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>Formula:C16H15Cl2N3O4Purity:99.87%Color and Shape:SolidMolecular weight:384.21AN3199
CAS:<p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>Formula:C17H18BNO5Purity:99.45%Color and Shape:SolidMolecular weight:327.14Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Formula:C13H13ClN4OPurity:98.97%Color and Shape:SolidMolecular weight:276.72BAY 73-6691
CAS:<p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>Formula:C15H12ClF3N4OColor and Shape:SolidMolecular weight:356.73Lirimilast
CAS:<p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>Formula:C17H12Cl2N2O6SPurity:98%Color and Shape:SolidMolecular weight:443.26WAY127093B racemate
CAS:<p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>Formula:C23H28N4O4Purity:99.67%Color and Shape:SolidMolecular weight:424.49PDE7-IN-2
CAS:<p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>Formula:C14H11ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:322.77(R)-DNMDP
CAS:<p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>Formula:C15H20N4O3Color and Shape:SolidMolecular weight:304.34Autotaxin-IN-1
CAS:<p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>Formula:C21H23N7O2Purity:98%Color and Shape:SolidMolecular weight:405.45Senazodan hydrochloride
CAS:<p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>Formula:C15H15ClN4OPurity:99.93%Color and Shape:SolidMolecular weight:302.76KD-027
CAS:<p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>Formula:C25H35N7O6SPurity:99.55%Color and Shape:SolidMolecular weight:561.65ATX inhibitor 5
CAS:<p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>Formula:C22H18ClF3N6OPurity:98.77%Color and Shape:SolidMolecular weight:474.87PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Formula:C19H17ClN2O2Purity:99.55%Color and Shape:SolidMolecular weight:340.8Imazodan
CAS:<p>Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.</p>Formula:C13H12N4OPurity:98% - 98.31%Color and Shape:SolidMolecular weight:240.26PDE IV-IN-1
CAS:<p>PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease</p>Formula:C20H23ClN4O2Purity:99.79%Color and Shape:SolidMolecular weight:386.88Tanimilast
CAS:<p>Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.</p>Formula:C30H30Cl2F2N2O8SPurity:98.34%Color and Shape:SolidMolecular weight:687.54uk-50001
CAS:<p>UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.</p>Formula:C26H24F3N3O4Purity:99.90%Color and Shape:SolidMolecular weight:499.48PDE4B-IN-2
CAS:<p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>Formula:C19H18ClN3O2SPurity:99.32%Color and Shape:SolidMolecular weight:387.88Nanterinone
CAS:<p>Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.</p>Formula:C15H15N3OPurity:99.53%Color and Shape:SolidMolecular weight:253.3Dovramilast
CAS:<p>Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.</p>Formula:C24H28N2O6SPurity:98.75% - 99.62%Color and Shape:SolidMolecular weight:472.55Verofylline
CAS:<p>Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the</p>Formula:C12H18N4O2Purity:98.33% - 98.83%Color and Shape:SolidMolecular weight:250.3Carbazeran
CAS:<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Formula:C18H24N4O4Purity:99.3%Color and Shape:SolidMolecular weight:360.41AWD 12-281
CAS:<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Formula:C22H14Cl2FN3O3Purity:99.25% - 99.85%Color and Shape:SolidMolecular weight:458.27Autotaxin-IN-3
CAS:<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Formula:C22H21N9O2Purity:99.54% - 99.79%Color and Shape:SolidMolecular weight:443.46Filaminast
CAS:<p>Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.</p>Formula:C15H20N2O4Purity:98.53% - 98.93%Color and Shape:SolidMolecular weight:292.33MK-0873
CAS:<p>MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.</p>Formula:C25H18N4O3Purity:98.40%Color and Shape:SolidMolecular weight:422.44Mopidamol
CAS:<p>Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental</p>Formula:C19H31N7O4Purity:99.05% - 99.78%Color and Shape:SolidMolecular weight:421.49Isomazole
CAS:<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Formula:C14H13N3O2SPurity:98.66%Color and Shape:SolidMolecular weight:287.34Tofimilast
CAS:<p>Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.</p>Formula:C18H21N5SPurity:99.55%Color and Shape:SolidMolecular weight:339.46Dasantafil
CAS:<p>Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.</p>Formula:C22H28BrN5O5Purity:99.4% - 99.50%Color and Shape:SolidMolecular weight:522.39PF-04447943
CAS:<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Formula:C20H25N7O2Purity:99.36% - 99.59%Color and Shape:SolidMolecular weight:395.46GSK356278
CAS:<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Formula:C21H25N7O2SPurity:99.90% - 99.97%Color and Shape:SolidMolecular weight:439.53MK-8189
CAS:<p>MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.</p>Formula:C19H22N6OSPurity:99.38% - 99.67%Color and Shape:SolidMolecular weight:382.48Autotaxin-IN-5
CAS:<p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Formula:C30H29N9O2Purity:98%Color and Shape:SolidMolecular weight:547.61Gisadenafil
CAS:<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Formula:C23H33N7O5SPurity:98.82% - 99.50%Color and Shape:SolidMolecular weight:519.62PDE5-IN-2
CAS:<p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>Formula:C25H21N3O6SPurity:98%Color and Shape:SolidMolecular weight:491.52CI-1044
CAS:<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Formula:C23H19N5O2Color and Shape:SolidMolecular weight:397.43BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formula:C28H31F6NO3Purity:98.03%Color and Shape:SolidMolecular weight:543.54Gisadenafil besylate
CAS:<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Formula:C29H39N7O8S2Color and Shape:SolidMolecular weight:677.79Difamilast
CAS:<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Formula:C23H24F2N2O5Purity:99.64%Color and Shape:SolidMolecular weight:446.44Siguazodan
CAS:<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Formula:C14H16N6OPurity:99.62% - 99.87%Color and Shape:SolidMolecular weight:284.32Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Formula:C16H14N4OPurity:99.52% - >99.99%Color and Shape:SolidMolecular weight:278.31Autotaxin-IN-4
CAS:<p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Formula:C22H21N9O2Purity:98%Color and Shape:SolidMolecular weight:443.46PF-04957325
CAS:<p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>Formula:C14H15F3N8OSPurity:99.02%Color and Shape:SolidMolecular weight:400.38PDE9-IN-(S)-C33
CAS:<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Formula:C18H20ClN5OPurity:98.75%Color and Shape:SolidMolecular weight:357.84Enpp-1-IN-16
CAS:<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Formula:C23H32N4O4Purity:99.87%Color and Shape:SolidMolecular weight:428.52TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formula:C24H35N5O3Purity:>99.99%Color and Shape:SolidMolecular weight:441.57AMG 579
CAS:<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Formula:C25H23N5O3Purity:99.87%Color and Shape:SolidMolecular weight:441.48Cudetaxestat
CAS:<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Formula:C21H15Cl2F2N3O2SPurity:99.9%Color and Shape:SolidMolecular weight:482.33TP-10
CAS:<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Formula:C26H19F3N4OPurity:99.21%Color and Shape:SolidMolecular weight:460.45Thioquinapiperifil dihydrochloride
CAS:<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Formula:C24H29ClN6OSPurity:98.73%Color and Shape:SolidMolecular weight:485.05PF-00489791
CAS:<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Formula:C20H28N8O4SPurity:99.97%Color and Shape:SolidMolecular weight:476.55Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71ASP9831
CAS:<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Formula:C20H23N3O3Color and Shape:SolidMolecular weight:353.42Tovinontrine
CAS:<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Formula:C21H26N6O2Purity:98.14%Color and Shape:SolidMolecular weight:394.47BMS-341400 mesylate
CAS:<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formula:C24H26ClN9O5SColor and Shape:SolidMolecular weight:588.039TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formula:C19H18F4N4O5Purity:98%Color and Shape:SolidMolecular weight:458.36Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formula:C12H14ClN3O3Color and Shape:SolidMolecular weight:283.71NHTD
CAS:<p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47
