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Glucokinase

Glucokinase

Glucokinase (GK) is an enzyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate, a critical step in glycolysis. GK is predominantly expressed in the liver and pancreas, where it plays a key role in regulating blood glucose levels. Inhibitors of GK are of interest in the study of metabolic disorders such as diabetes, as they can modulate glucose metabolism and insulin secretion. At CymitQuimica, we provide glucokinase inhibitors to support your research in diabetes, metabolism, and therapeutic development.

Found 53 products of "Glucokinase"

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  • 3PO
    Targetmol
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    3PO

    CAS:
    <p>3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.</p>
    Formula:C13H10N2O
    Purity:99.56% - 99.67%
    Color and Shape:Solid
    Molecular weight:210.23

    Ref: TM-T22223

  • Palmitelaidic Acid
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    Palmitelaidic Acid

    CAS:
    <p>Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.</p>
    Formula:C16H30O2
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:254.41

    Ref: TM-T19500

  • (E)-3PO
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    (E)-3PO

    CAS:
    <p>(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.</p>
    Formula:C13H10N2O
    Purity:98.8% - 98.92%
    Color and Shape:Solid
    Molecular weight:210.23

    Ref: TM-T3260

  • PFK-015
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    PFK-015

    CAS:
    <p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>
    Formula:C17H12N2O
    Purity:99.7% - 99.85%
    Color and Shape:Solid
    Molecular weight:260.29

    Ref: TM-T2455

  • Genz-123346 free base
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    Genz-123346 free base

    CAS:
    <p>Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.</p>
    Formula:C24H38N2O4
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:418.57

    Ref: TM-T4049

  • AMG-3969
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    AMG-3969

    CAS:
    <p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>
    Formula:C21H20F6N4O3S
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:522.46

    Ref: TM-TQ0055

  • Glucokinase activator 3
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    Glucokinase activator 3

    CAS:
    <p>Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.</p>
    Formula:C26H33N2O9PS2
    Color and Shape:Solid
    Molecular weight:612.65

    Ref: TM-T72284

  • RO-28-1675
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    RO-28-1675

    CAS:
    <p>RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.</p>
    Formula:C18H22N2O3S2
    Purity:98.13%
    Color and Shape:Solid
    Molecular weight:378.51

    Ref: TM-T16793

  • PSN-GK1
    Targetmol
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    PSN-GK1

    CAS:
    <p>PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).</p>
    Formula:C20H23FN2O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.54

    Ref: TM-T10092

  • GKA-22
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    GKA-22

    CAS:
    <p>GKA-22 is a human glucokinase allosteric activator in the absence of glucose.</p>
    Formula:C22H22N2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.49

    Ref: TM-T25451

  • Piragliatin
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    Piragliatin

    CAS:
    <p>Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.</p>
    Formula:C19H20ClN3O4S
    Color and Shape:Solid
    Molecular weight:421.9

    Ref: TM-T68976

  • Glucokinase activator 1
    Targetmol
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    Glucokinase activator 1

    CAS:
    <p>Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).</p>
    Formula:C27H20F2N2O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:586.58

    Ref: TM-T11418

  • IHVR-11029
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    IHVR-11029

    CAS:
    <p>IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.</p>
    Formula:C18H27F2NO5
    Color and Shape:Solid
    Molecular weight:375.41

    Ref: TM-T27590

  • GKA-71
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    GKA-71

    CAS:
    <p>GKA-71 is an effective glucokinase activator (GKA).</p>
    Formula:C21H23N3O6S2
    Color and Shape:Solid
    Molecular weight:477.55

    Ref: TM-T25452

  • PF-04279405
    Targetmol
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    PF-04279405

    CAS:
    <p>PF-04279405 is a potent and selective glucokinase activator.</p>
    Formula:C25H25FN4O4
    Color and Shape:Solid
    Molecular weight:464.49

    Ref: TM-T68244

  • Cefetrizole
    Targetmol
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    Cefetrizole

    CAS:
    <p>Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).</p>
    Formula:C16H15N5O4S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:437.52

    Ref: TM-T10751

  • YZ9
    Targetmol
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    YZ9

    CAS:
    <p>Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].</p>
    Formula:C12H10O5
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:234.2

    Ref: TM-T23552

  • AMG-1694
    Targetmol
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    AMG-1694

    CAS:
    <p>AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.</p>
    Formula:C23H30F3N3O4S2
    Purity:98.37%
    Color and Shape:Solid
    Molecular weight:533.63

    Ref: TM-T14212

  • AR453588
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    AR453588

    CAS:
    <p>AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>
    Formula:C25H25N7O2S2
    Color and Shape:Solid
    Molecular weight:519.64

    Ref: TM-T10362

  • KDM4-IN-2
    Targetmol
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    KDM4-IN-2

    CAS:
    <p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>
    Formula:C25H26N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.51

    Ref: TM-T11749