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SGK

SGK

Serum and Glucocorticoid-Regulated Kinase (SGK) is a protein kinase involved in the regulation of various cellular processes, including ion transport, cell survival, and glucose metabolism. SGK inhibitors are valuable in the study of conditions such as hypertension, diabetes, and cancer, where SGK activity plays a crucial role. These inhibitors help in understanding the signaling pathways regulated by SGK and their implications in disease. At CymitQuimica, we offer SGK inhibitors to support your research in signal transduction, metabolic diseases, and cancer therapy.

Found 11 products of "SGK"

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  • CymitQuimica logo
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    SGK1-IN-3 hydrochloride

    <p>SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.</p>
    Formula:C23H21Cl3N6O3S
    Molecular weight:566.04614

    Ref: TM-T210357

  • PROTAC SGK3 degrader-1
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    PROTAC SGK3 degrader-1

    CAS:
    <p>PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligands to VH032 VHL to induce endogenous SGK3 degradation.</p>
    Formula:C57H73FN10O11S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1157.38

    Ref: TM-T13847

  • SGK1-IN-4
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    SGK1-IN-4

    CAS:
    <p>SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.</p>
    Formula:C23H21ClFN5O4S
    Purity:97.03%
    Color and Shape:Solid
    Molecular weight:517.96

    Ref: TM-T9977

  • SI-113
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    SI-113

    CAS:
    <p>SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.</p>
    Formula:C23H24N6O
    Purity:98.93%
    Color and Shape:Solid
    Molecular weight:400.48

    Ref: TM-T9589

  • CKI-7
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    CKI-7

    CAS:
    <p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>
    Formula:C11H14Cl3N3O2S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:358.67

    Ref: TM-T19913

  • GSK 650394
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    GSK 650394

    CAS:
    <p>GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.</p>
    Formula:C25H22N2O2
    Purity:97.46% - >99.99%
    Color and Shape:Solid
    Molecular weight:382.45

    Ref: TM-T2622

  • EMD638683
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    EMD638683

    CAS:
    <p>EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).</p>
    Formula:C18H18F2N2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:364.34

    Ref: TM-T6635

  • SGK1-IN-1
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    SGK1-IN-1

    CAS:
    <p>SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor</p>
    Formula:C17H12ClFN6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:418.83

    Ref: TM-T12890

  • BRD7389
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    BRD7389

    CAS:
    <p>BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.</p>
    Formula:C24H18N2O2
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:366.41

    Ref: TM-T14779

  • EMD638683 R-Form
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    EMD638683 R-Form

    CAS:
    <p>EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.</p>
    Formula:C18H18F2N2O4
    Color and Shape:Solid
    Molecular weight:364.34

    Ref: TM-T11181

  • SGK1-IN-6
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    SGK1-IN-6

    CAS:
    <p>SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.</p>
    Formula:C30H30F3N5O4
    Color and Shape:Solid
    Molecular weight:581.586

    Ref: TM-T205289