HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 142 products of "HIF/HIF Prolyl-Hydroxylase"
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HIF-PHD-IN-2
CAS:<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Formula:C17H15N5O3SColor and Shape:SolidMolecular weight:369.4Angiogenesis agent 1
CAS:<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Formula:C20H24O7Purity:98%Color and Shape:SolidMolecular weight:376.4BNS
CAS:<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Formula:C18H16N2O6S2Purity:98%Color and Shape:SolidMolecular weight:420.46M1002
CAS:<p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>Formula:C15H8F6N2O2SPurity:99.95%Color and Shape:SolidMolecular weight:394.29103D5R
CAS:<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Formula:C20H21N3O2Color and Shape:SolidMolecular weight:335.4HIF-IN-33
CAS:<p>HIF-IN-33 is an inhibitor of HIF pathway.</p>Formula:C21H17F3N4O2Purity:98%Color and Shape:SolidMolecular weight:414.38Langkamide
CAS:<p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>Formula:C16H17NO5Purity:98%Color and Shape:SolidMolecular weight:303.31ENMD-1198
CAS:<p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>Formula:C20H25NO2Purity:98%Color and Shape:SolidMolecular weight:311.42HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Formula:C16H11FN4O2SColor and Shape:SolidMolecular weight:342.35THS-044
CAS:<p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>Formula:C11H12F3N3O3Purity:99.89%Color and Shape:SolidMolecular weight:291.23KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Formula:C26H27NO5SColor and Shape:SolidMolecular weight:465.56TM6089
CAS:<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Formula:C13H14N4O3SPurity:99.70%Color and Shape:SolidMolecular weight:306.34HIF-1α inhibitor-1
CAS:<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Formula:C15H11N3O4Color and Shape:SolidMolecular weight:297.27KRH102140
CAS:<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46HIF-2α-IN-3
CAS:<p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>Formula:C12H6ClN5O5Purity:98.11%Color and Shape:SolidMolecular weight:335.66TC-S 7009
CAS:<p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.</p>Formula:C12H6ClFN4O3Purity:99.46% - 99.71%Color and Shape:SolidMolecular weight:308.65HIF-2α-IN-13
CAS:<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Formula:C15H14ClF4NO2Color and Shape:SolidMolecular weight:351.72PHD-IN-2
CAS:<p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>Formula:C26H27N7O4Purity:98%Color and Shape:SolidMolecular weight:501.54Prolyl Hydroxylase inhibitor 1
CAS:<p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>Formula:C19H18ClN5O4Purity:98%Color and Shape:SolidMolecular weight:415.83PHD2-IN-1
CAS:<p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>Formula:C21H23ClN4O5Purity:98%Color and Shape:SolidMolecular weight:446.88HIF-2α-IN-9
CAS:<p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>Formula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35PHD-IN-1
CAS:<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49AKB-6899
CAS:<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Formula:C14H11FN2O4Purity:97.87%Color and Shape:SolidMolecular weight:290.25HIF-2α-IN-1
CAS:<p>HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.</p>Formula:C16H8F5NO4SPurity:97.99%Color and Shape:SolidMolecular weight:405.3CLB-016
CAS:<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Formula:C17H20N6O3Purity:98%Color and Shape:SolidMolecular weight:356.38HIF-2α-IN-6
CAS:<p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>Formula:C15H13F4NO3SColor and Shape:SolidMolecular weight:363.33NPAS3-IN-1
CAS:<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Formula:C10H5N3O2S3Purity:99.56%Color and Shape:SolidMolecular weight:295.36HIF-2α agonist 2
CAS:<p>HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.</p>Formula:C13H8Br2N2O2SPurity:98.87%Color and Shape:SoildMolecular weight:416.09HIF-2α-IN-7
CAS:<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formula:C18H9F6NO2Color and Shape:SolidMolecular weight:385.26HIF-2α-IN-5
CAS:<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Formula:C15H12F4O3S2Color and Shape:SolidMolecular weight:380.38(Rac)-PT2399
CAS:<p>(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).</p>Formula:C17H10F5NO4SColor and Shape:SolidMolecular weight:419.32JTZ-951 HCl
CAS:<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Formula:C17H17ClN4O4Purity:98%Color and Shape:SolidMolecular weight:376.79AFP464 free base
CAS:<p>AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.</p>Formula:C22H23F3N4O3Purity:98%Color and Shape:SolidMolecular weight:448.44HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formula:C16H15N3O2Color and Shape:SolidMolecular weight:281.31DDO-3055
CAS:<p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749JPHM-2-167
CAS:<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.582HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Formula:C16H12N2O3Color and Shape:SolidMolecular weight:280.28DS44470011
CAS:<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formula:C21H19N3O4Color and Shape:SolidMolecular weight:377.39PHD2-IN-4
CAS:<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Formula:C21H19N5O3Color and Shape:SolidMolecular weight:389.407HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Formula:C17H16N6O4Color and Shape:SolidMolecular weight:368.35HIF-PHD-IN-1
CAS:<p>HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.</p>Formula:C17H12Cl2N6O3Color and Shape:SolidMolecular weight:419.22Desidustat
CAS:<p>Desidustat is an inhibitor of HIF hydroxylase.</p>Formula:C16H16N2O6Purity:98%Color and Shape:SolidMolecular weight:332.31
