Carbonic Anhydrase
Carbonic anhydrase is an enzyme that catalyzes the reversible conversion of carbon dioxide and water into bicarbonate and protons. This enzyme plays a crucial role in maintaining acid-base balance, respiration, and the transport of carbon dioxide in the blood. Inhibitors of carbonic anhydrase are used in the treatment of glaucoma, epilepsy, and altitude sickness, as well as in research on acid-base homeostasis and gas exchange. At CymitQuimica, we offer a range of high-quality carbonic anhydrase inhibitors and reagents to support your research in enzymology, respiratory physiology, and therapeutic development.
Found 177 products of "Carbonic Anhydrase"
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DPP IV/hCA II-IN-1
CAS:<p>DPP IV/hCA II-IN-1: strong DPP IV & CA inhibitor, IC50=0.049μM (DPP IV), Ki=0.0361-3.034μM (CA II-IV).</p>Formula:C17H20N2O5SColor and Shape:SolidMolecular weight:364.42Bendroflumethiazide
CAS:<p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>Formula:C15H14F3N3O4S2Purity:98% - >99.99%Color and Shape:Crystals From Dioxane SolidMolecular weight:421.41Carbonic anhydrase
CAS:<p>Carbonic anhydrase, a zinc enzyme in all life forms, converts CO2 to bicarbonate; studied for cancer, glaucoma, obesity, epilepsy.</p>Color and Shape:SolidCarbonic anhydrase inhibitor 26
<p>Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.</p>Formula:C17H14N6O4Color and Shape:SolidMolecular weight:366.33AV22-149
<p>AV22-149 (compound 22) is an inhibitor of Carbonic Anhydrase .</p>Formula:C23H28F3N3O6S2Color and Shape:SolidMolecular weight:563.61DOTA-XYIMSR-01
CAS:<p>DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.</p>Formula:C61H88N16O22S2Color and Shape:SolidMolecular weight:1461.57Acesulfame
CAS:<p>Acesulfame inhibits CA9/12 and can be used to study inflammation-related diseases.</p>Formula:C4H5NO4SColor and Shape:SolidMolecular weight:163.15Carbonic anhydrase inhibitor 18
<p>Carbonic anhydrase inhibitor18 (Compound 9) is an inhibitor of human carbonic anhydrase (hCA) isozymes, with Ki values of 604.8 nM for hCA I, 333.6 nM for hCA II, 1.9 nM for hCA IX, and 6.7 nM for hCA XII. Carbonic anhydrase inhibitor18 is applicable in cancer research.</p>Formula:C26H28N4O6S2Molecular weight:556.14503Girentuximab
CAS:<p>Girentuximab (G250) is an anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anti-cancer activity for the study of uroepithelial carcinoma PET (ZiPUP).</p>Color and Shape:LiquidMolecular weight:145.55 kDahCAIX/XII-IN-11
<p>hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.7 μM for both isoforms. This compound is applicable in cancer research.</p>Formula:C13H10FN3O4Molecular weight:291.06553GZ22-4
<p>GZ22-4 is a near-infrared (NIR) fluorescent probe with a high affinity for carbonic anhydrase IX (CAIX), exhibiting a dissociation constant (Kd) of 0.2 nM. It is applicable in studies for visualizing CAIX-positive tumors.</p>Formula:C88H126F3N6NaO24S4Molecular weight:1858.75561SH7s
<p>SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.</p>Formula:C24H19ClF3N5O4SColor and Shape:SolidMolecular weight:565.95hCA XII-IN-6
<p>Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative</p>Formula:C11H9N5O3S2Purity:98%Color and Shape:SolidMolecular weight:323.35Chlorothiazide
CAS:<p>Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.</p>Formula:C7H6ClN3O4S2Purity:98.46% - 98.91%Color and Shape:Crystals Physical Description Crystals; White Powder (Ntp 1992)Molecular weight:295.72Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)
<p>Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues.</p>Color and Shape:Lyophilized PowderMolecular weight:32.04 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.Acetazolamide-d3
CAS:<p>Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor.</p>Formula:C4H6N4O3S2Purity:98%Color and Shape:SolidMolecular weight:225.26M 12325
CAS:<p>M 12325 is used in the production of furosemide; rhinitis and occupational asthma were observed in workers from a lasamide production line.</p>Formula:C7H5Cl2NO4SColor and Shape:White To Almost White Solid PowderMolecular weight:270.09Brinzolamide hydrochloride
<p>Brinzolamide (AL-4862) HCl selectively inhibits carbonic anhydrase II, reducing IOP for glaucoma research. IC50: 3.2 nM.</p>Color and Shape:Solid4-(benzyloxy)benzene-1-sulfonamide
CAS:<p>4-(benzyloxy)benzene-1-sulfonamide is inhibitor of human recombinant CA-7.</p>Formula:C13H13NO3SPurity:97.54%Color and Shape:SolidMolecular weight:263.31Zolamide
CAS:<p>Zolamide (CL 5343) may be used to prevent altitude sickness and reduce the symptoms.</p>Formula:C2H4N4O2S2Purity:99.75%Color and Shape:SolidMolecular weight:180.21EMAC10101d
CAS:<p>compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an</p>Formula:C17H15Cl2N3O2S2Purity:99.96%Color and Shape:SolidMolecular weight:428.36Benzenesulfonamide
CAS:<p>Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.</p>Formula:C6H7NO2SPurity:99.42% - 99.99%Color and Shape:White Crystalline PowderMolecular weight:157.19Dichlorphenamide
CAS:<p>Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.</p>Formula:C6H6Cl2N2O4S2Purity:96.87% - 97.25%Color and Shape:Needles From Dimethylsulfoxide + Water SolidMolecular weight:305.16Benzolamide
CAS:<p>Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.</p>Formula:C8H8N4O4S3Purity:99.31%Color and Shape:SolidMolecular weight:320.37Dichlorphenamide disodium
CAS:<p>Dichlorphenamide disodium: an oral carbonic anhydrase inhibitor that lowers eye pressure, promising for glaucoma study.</p>Formula:C6H6Cl2N2Na2O4S2Color and Shape:SolidMolecular weight:351.12Dimethylfraxetin
CAS:<p>Dimethylfraxetin (6,7,8-Trimethoxycoumarin) is a Carbonic anhydrase inhibitor(Ki：0.0097 μM)</p>Formula:C12H12O5Purity:99.96% - ≥95%Color and Shape:SolidMolecular weight:236.224-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
CAS:<p>4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide (4-Amino-6-(trifluoromethyl)benzene-1,3-d) is a carbonic anhydrase inhibitor, used as a potential anti-</p>Formula:C7H8F3N3O4S2Purity:98.58%Color and Shape:SolidMolecular weight:319.28Dorzolamide hydrochloride
CAS:<p>Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that</p>Formula:C10H17ClN2O4S3Purity:99.48% - 99.67%Color and Shape:White Off-White Crystalline PowderMolecular weight:360.9Methyclothiazide
CAS:<p>Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including</p>Formula:C9H11Cl2N3O4S2Purity:99.13%Color and Shape:SolidMolecular weight:360.242,3-dihydro-1H-indene-5-sulfonamide
CAS:<p>2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.</p>Formula:C9H11NO2SPurity:99.89%Color and Shape:SolidMolecular weight:197.25Orthanilamide
CAS:<p>Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.</p>Formula:C6H8N2O2SPurity:99.72% - 99.96%Color and Shape:White To Pale Cream Crystalline Powder Or CrystalsMolecular weight:172.2Indisulam
CAS:<p>Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.</p>Formula:C14H12ClN3O4S2Purity:98.68% - 99.77%Color and Shape:SolidMolecular weight:385.85U-104
CAS:<p>U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).</p>Formula:C13H12FN3O3SPurity:98.76% - 99.88%Color and Shape:SolidMolecular weight:309.32Ethoxzolamide
CAS:<p>Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.</p>Formula:C9H10N2O3S2Purity:98.27% - 99.62%Color and Shape:Crystals From Ethyl Acetate + Skellysolve B SolidMolecular weight:258.32Polmacoxib
CAS:<p>Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.</p>Formula:C18H16FNO4SPurity:97.88%Color and Shape:SolidMolecular weight:361.39Fluorometholone Acetate
CAS:<p>Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.</p>Formula:C24H31FO5Purity:99.76%Color and Shape:SolidMolecular weight:418.50GV2-20
CAS:<p>GV2-20 is an effective carbonic anhydrase 2 inhibitors.</p>Formula:C15H13N3O6Purity:98%Color and Shape:SolidMolecular weight:331.28Disulfamide
CAS:<p>Disulfamide: Oral carbonic anhydrase inhibitor, IC50 0.07 μM, diuretic by blocking Na+/HCO3- reabsorption.</p>Formula:C7H9ClN2O4S2Purity:98.1%Color and Shape:SolidMolecular weight:284.74HCAIX-IN-2
CAS:<p>HCAIX-IN-2 (compound 9d) is a selective inhibitor of carbonic anhydrase and acts on hCA IX (Ki: 24.6 nM) and hCA XII (Ki: 45.3 nM).</p>Formula:C19H16N8O4SColor and Shape:SolidMolecular weight:452.45hCAIX-IN-11
CAS:<p>hCAIX-IN-11 inhibits carbonic anhydrases IX & XII with Ki of 32.7 nM & 623.5 nM, respectively.</p>Formula:C21H15ClN4O3Color and Shape:SolidMolecular weight:406.82hCAI/II-IN-1
CAS:<p>hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor that acts on hCA I (IC50: 0.047 μM) and hCA II (IC50: 0.024 μM).</p>Formula:C18H29N5O3S3Color and Shape:SolidMolecular weight:459.65hCAIX/XII-IN-2
CAS:<p>Compound 6a: Selective hCAIX/XII inhibitor; Ki: 30 nM (hCAIX), 3.6 nM (hCAXII); >10,000 nM (hCAI/II).</p>Formula:C19H14N2O4Color and Shape:SolidMolecular weight:334.33CDK2-IN-12
CAS:<p>CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.</p>Formula:C20H17N9O2SColor and Shape:SolidMolecular weight:447.47Clofenamide
CAS:<p>Clofenamide is a low-ceiling sulfonamide diuretic.</p>Formula:C6H7ClN2O4S2Color and Shape:SolidMolecular weight:270.71hCAII-IN-2
CAS:<p>hCAII-IN-2 inhibits human carbonic anhydrases I, II, IX, XII with Ki values of 261.4, 3.8, 19.6, 45.2 nM respectively.</p>Formula:C25H18ClN5O4SColor and Shape:SolidMolecular weight:519.96hCAIX/XII-IN-3
CAS:<p>Compound 6q inhibits hCAIX/CAXII; K i : hCAI >10000 nM, hCAII >10000 nM, hCAIX 66.2 nM, hCAXII 4.4 nM.</p>Formula:C20H13F3N2O4Color and Shape:SolidMolecular weight:402.32CDK2-IN-11
CAS:<p>CDK2-IN-11 inhibits CDK2 (IC50: 6.4 μM) and targets hCA II, IX, XII (Ki: 23.4-56.3 nM); suited for cancer research.</p>Formula:C18H14ClN7O2SColor and Shape:SolidMolecular weight:427.87hCA I-IN-1
CAS:<p>hCA I-IN-1 inhibits hCA I (Ki: 38.3 nM), II (Ki: 716.4 nM), IX (Ki: 940.1 nM), XII (Ki: 192.8 nM).</p>Formula:C27H23N5O4SColor and Shape:SolidMolecular weight:513.57hCAXII-IN-3
CAS:<p>hCAXII-IN-3 (Compound 6o) is a selective inhibitor of human carbonic anhydrase XII (hCAXII) (Ki: 10.0 nM).</p>Formula:C26H20BrN5O3SColor and Shape:SolidMolecular weight:562.44Carbonic anhydrase inhibitor 14
CAS:<p>CA inhibitor 14 blocks hCA I/II/IX/XII (K i of 1203/99.7/9.4/27.7 nM) and CDK2 (IC50: 20.3 μM), showing antitumor effects.</p>Formula:C18H17N7O2SColor and Shape:SolidMolecular weight:395.44
