CAS 133-67-5

Trichlormethiazide

Description:

Trichlormethiazide is a thiazide diuretic commonly used in the treatment of hypertension and edema associated with various medical conditions. It is characterized by its chemical formula, which includes chlorine and sulfur atoms, contributing to its pharmacological properties. The compound works by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, leading to increased urine output and decreased blood volume. Trichlormethiazide is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing in many cases. Its solubility in water is limited, which can affect its absorption and bioavailability. The substance may also exhibit side effects, including electrolyte imbalances, particularly hypokalemia, and should be used with caution in patients with renal impairment. Overall, trichlormethiazide is an important medication in the management of cardiovascular conditions, and its efficacy is enhanced when used in conjunction with other antihypertensive agents.

Formula: C₈H₈Cl₃N₃O₄S₂

InChI: InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

InChI key: InChIKey=LMJSLTNSBFUCMU-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(C(Cl)Cl)N1)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
• 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
• 3-Dichloromethylhydrochlorothiazide
• 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 6-Chloro-3-(dichloromethyl)-3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
• 6-Chloro-3-dichloromethyl-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide-1, 1-dioxide
• 6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Achletin
• Anatran
• Anistadin
• Aponorin
• Carvacron
• Ciba 7057-Su
• Diurazida
• Diurese
• Diuroral
• Esmarin
• Fluitran
• Flurese
• Flutra
• Gangesol
• Hydrotrichlorothiazide
• Intromene
• Kubacron
• Metahydrin
• Metatensin
• Nakva
• Naqua
• Naquasone
• Naquival
• Nsc 61560
• Salirom
• Tachionin
• Tolcasone
• Trichlormetazid
• Trichlormethiazid
• Trichlormethiazide
• Trichloromethiazide
• Triclormetiazida
• Triflumen

Trichloromethiazide

CAS: 133-67-5

Formula: C₈H₈Cl₃N₃O₄S₂

Purity: >99.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 380.64

Ref: 3B-T1318

Trichlormethiazide

CAS: 133-67-5

Sulfonamides used as drugs

Formula: C₈H₈Cl₃N₃O₄S₂

Color and Shape: White Powder

Molecular weight: 380.67 g/mol

Ref: 45-1681000

6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

CAS: 133-67-5

Formula: C₈H₈Cl₃N₃O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 380.6558

Ref: IN-DA003V0G

Trichlormethiazide

CAS: 133-67-5

Trichlormethiazide

Formula: C₈H₈Cl₃N₃O₄S₂

Purity: 98%

Molecular weight: 380.66

Ref: 54-OR1015308

Trichlormethiazide

CAS: 133-67-5

Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics.

Formula: C₈H₈Cl₃N₃O₄S₂

Purity: 98.8% - 99.54%

Color and Shape: Solid

Molecular weight: 380.66

Ref: TM-T0114

Trichlormethiazide

CAS: 133-67-5

Trichlormethiazide

Formula: C₈H₈Cl₃N₃O₄S₂

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 380.66

Ref: 54-BUP18296

Trichlormethiazide

CAS: 133-67-5

Formula: C₈H₈Cl₃N₃O₄S₂

Molecular weight: 380.64

Ref: 4Z-T-407001

Trichlormethiazide

CAS: 133-67-5

Formula: C₈H₈Cl₃N₃O₄S₂

Color and Shape: Neat

Molecular weight: 380.66

Ref: 04-C17682000

Trichlormethiazide (Standard)

CAS: 133-67-5

Trichlormethiazide (Standard) is the standard substance of Trichlormethiazide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule.

Formula: C₈H₈Cl₃N₃O₄S₂

Color and Shape: Solid

Molecular weight: 380.66

Ref: TM-TMSM-2301

Trichlormethiazide

Controlled Product

CAS: 133-67-5

Formula: C₈H₈Cl₃N₃O₄S₂

Color and Shape: White Solid

Molecular weight: 380.66

Ref: 86-MM3285.00

Trichlormethiazide

Controlled Product

CAS: 133-67-5

Applications Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
References Imamura, T., et al.: International Heart J., 54(1), 48 (2013); Takahashi, Y., et al.: Cardiovas. Diabetology, 10(1), 45 (2011);

Formula: C₈H₈Cl₃N₃O₄S₂

Color and Shape: Neat

Molecular weight: 380.66

Ref: TR-T774335

TRICHLORMETHIAZIDE

CAS: 133-67-5

Purity: 98%(LC-MS);RG

Molecular weight: 380.6400146

Ref: 10-F799938

Trichlormethiazide

CAS: 133-67-5

Formula: C₈H₈Cl₃N₃O₄S₂

Molecular weight: 380.64

Ref: ST-EA-CP-T55000

Trichlormethiazide RS

CAS: 133-67-5

Color and Shape: White Solid Powder

Ref: 2K-1096000021