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PPAR

PPAR

Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes involved in metabolism, particularly fatty acid storage and glucose metabolism. PPAR inhibitors are important tools for studying metabolic disorders such as diabetes, obesity, and cardiovascular diseases. These inhibitors can modulate lipid metabolism, insulin sensitivity, and inflammation, making them valuable in therapeutic research. At CymitQuimica, we offer a range of PPAR inhibitors to support your research in metabolic diseases, endocrinology, and drug development.

Found 164 products of "PPAR"

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  • Ragaglitazar
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    Ragaglitazar

    CAS:
    <p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>
    Formula:C25H25NO5
    Purity:97.46% - 98.56%
    Color and Shape:Solid
    Molecular weight:419.47

    Ref: TM-T28501

  • Inolitazone
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    Inolitazone

    CAS:
    <p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>
    Formula:C27H26N4O4S
    Purity:99.41% - 99.53%
    Color and Shape:Solid
    Molecular weight:502.58

    Ref: TM-T15581

  • Fonadelpar
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    Fonadelpar

    CAS:
    <p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>
    Formula:C25H23F3N2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:504.52

    Ref: TM-T15336

  • Anti-NASH agent 2
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    Anti-NASH agent 2

    CAS:
    <p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>
    Formula:C32H51N3O2
    Color and Shape:Solid
    Molecular weight:509.766

    Ref: TM-T204253

  • PPARγ agonist 17
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    PPARγ agonist 17

    CAS:
    <p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>
    Formula:C48H63NO7
    Color and Shape:Solid
    Molecular weight:766.016

    Ref: TM-T206082

  • PPARγ modulator-2
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    PPARγ modulator-2

    CAS:
    <p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>
    Formula:C26H21NO7S3Se
    Color and Shape:Solid
    Molecular weight:634.6

    Ref: TM-T205068

  • Amezalpat
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    Amezalpat

    CAS:
    <p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>
    Formula:C34H41N3O4
    Color and Shape:Solid
    Molecular weight:555.707

    Ref: TM-T205015

  • PPARγ-IN-5
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    PPARγ-IN-5

    CAS:
    <p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>
    Formula:C22H23ClO7
    Color and Shape:Solid
    Molecular weight:434.867

    Ref: TM-T205246

  • PPARα/δ agonist 3
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    PPARα/δ agonist 3

    CAS:
    <p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>
    Formula:C23H25F3N2O4
    Color and Shape:Solid
    Molecular weight:450.451

    Ref: TM-T205373

  • PPARδ agonist 11
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    PPARδ agonist 11

    CAS:
    <p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>
    Formula:C19H15F3N2O3S2
    Color and Shape:Solid
    Molecular weight:440.46

    Ref: TM-T200543

  • Aleglitazar
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    Aleglitazar

    CAS:
    <p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>
    Formula:C24H23NO5S
    Purity:99.03%
    Color and Shape:Solid
    Molecular weight:437.51

    Ref: TM-T14176

  • Anti-NASH agent 1
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    Anti-NASH agent 1

    CAS:
    <p>Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).</p>
    Formula:C26H33NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.54

    Ref: TM-T79454

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  • PPARγ-IN-2
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    PPARγ-IN-2

    CAS:
    <p>"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.</p>
    Formula:C19H21N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:335.4

    Ref: TM-T79678

    5mg
    Discontinued
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  • CymitQuimica logo
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    Mavodelpar free base

    CAS:
    <p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>
    Formula:C31H30FNO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:515.57

    Ref: TM-T12527

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    Discontinued product