HMG-CoA Reductase

HMG-CoA Reductase is a key enzyme in the mevalonate pathway, responsible for the synthesis of cholesterol and other isoprenoids. Inhibitors of HMG-CoA reductase, commonly known as statins, are widely used to lower cholesterol levels and reduce the risk of cardiovascular diseases. These inhibitors also have potential benefits in cancer and neurodegenerative disease research. At CymitQuimica, we provide a variety of HMG-CoA reductase inhibitors to support your research in lipid metabolism, cardiovascular health, and therapeutic development.

Found 32 products of "HMG-CoA Reductase"

Purity (%)

100

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Atorvastatin lactone
CAS:
- 125995-03-1
Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
Formula:C₃₃H₃₃FN₂O₄
Purity:98.05% - 98.16%
Color and Shape:Solid
Molecular weight:540.62
Ref: TM-T14342
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Monacolin J
CAS:
- 79952-42-4
Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.
Formula:C₁₉H₂₈O₄
Purity:98.06%
Color and Shape:Solid
Molecular weight:320.42
Ref: TM-T12092
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Lipid Metabolism Compound Library
A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).
Color and Shape:Odour Solid
Ref: TM-L2510
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(3S,5R)-Fluvastatin D6 sodium
CAS:
- 2249799-35-5
(3S,5R)-Fluvastatin D6 sodium: deuterium-labeled synthetic HMG-CoA reductase inhibitor with 8 nM IC50.
Formula:C₂₄H₂₅FNNaO₄
Purity:98%
Color and Shape:Solid
Molecular weight:439.49
Ref: TM-T10128
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L 645164
CAS:
- 85493-98-7
L 645164 is an inhibitor of hydroxymethylglutaryl-CoA reductase.
Formula:C₂₂H₂₃FO₃
Color and Shape:Solid
Molecular weight:354.41
Ref: TM-T24301
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Ganoderenic acid K
CAS:
- 942950-94-9
Ganoderenic acid K, from Ganoderma lucidum, inhibits HMG-CoA reductase with an IC50 of 16.5 μM.
Formula:C₃₂H₄₄O₉
Color and Shape:Solid
Molecular weight:572.69
Ref: TM-T75626
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Rawsonol
CAS:
- 125111-69-5
Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni.
Formula:C₂₉H₂₄Br₄O₇
Color and Shape:Solid
Molecular weight:804.11
Ref: TM-T26044
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(Rac)-5-Keto Fluvastatin
CAS:
- 1160169-39-0
(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) is an impurity of Fluvastatin which is an inhibitor of HMG-CoA reductase.
Formula:C₂₄H₂₄FNO₄
Purity:95.04%
Color and Shape:Solid
Molecular weight:409.45
Ref: TM-T12652
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HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm
Formula:C₂₇H₂₉N₃O₇
Color and Shape:Solid
Molecular weight:507.54
Ref: TM-T79520
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Atorvastatin calcium trihydrate
CAS:
- 344423-98-9
Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease.
Formula:C₆₆H₇₄CaF₂N₄O₁₃
Color and Shape:Solid
Molecular weight:1209.39
Ref: TM-T21363
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Pravastatin lactone
CAS:
- 85956-22-5
Pravastatin lactone, a non-enzymatic stomach derivative of pravastatin, inhibits HMG-CoA reductase and stems from mevastatin.
Formula:C₂₃H₃₄O₆
Color and Shape:Solid
Molecular weight:406.519
Ref: TM-T37642
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PPD 10558
CAS:
- 805241-79-6
PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.
Formula:C₃₄H₃₇FN₂O₆
Color and Shape:Solid
Molecular weight:588.67
Ref: TM-T28440
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SR12813
CAS:
- 126411-39-0
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.
Formula:C₂₄H₄₂O₇P₂
Purity:99.43%
Color and Shape:Solid
Molecular weight:504.53
Ref: TM-T6994
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Clinofibrate
CAS:
- 30299-08-2
Clinofibrate lowers lipids, blocks HMGCR (IC50: 0.47 mM), and controls cholesterol/triacylglycerides.
Formula:C₂₈H₃₆O₆
Purity:>99.99%
Color and Shape:White Crystalline Powder
Molecular weight:468.58
Ref: TM-T6450
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7-Ketocholesterol
CAS:
- 566-28-9
7-Ketocholesterol is a metabolite of Cholesterol
Formula:C₂₇H₄₄O₂
Purity:97.59% - 98.84%
Color and Shape:Solid
Molecular weight:400.65
Ref: TM-TN6715
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Simvastatin acid ammonium
CAS:
- 139893-43-9
Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.
Formula:C₂₅H₄₃NO₆
Purity:98.3%
Color and Shape:Solid
Molecular weight:453.61
Ref: TM-T16885
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Tenivastatin
CAS:
- 121009-77-6
Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor used in the study of primary hyperlipidemia.
Formula:C₂₅H₄₀O₆
Purity:99.56%
Color and Shape:Solid
Molecular weight:436.58
Ref: TM-T24865
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Atorvastatin
CAS:
- 134523-00-5
Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.
Formula:C₃₃H₃₅FN₂O₅
Purity:99.37% - 99.69%
Color and Shape:Solid
Molecular weight:558.64
Ref: TM-T20765
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4-Acetylsimvastatin
CAS:
- 145576-25-6
4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).
Formula:C₂₇H₄₀O₆
Purity:98%
Color and Shape:Solid
Molecular weight:460.6
Ref: TM-T10136
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Lovastatin hydroxy acid sodium
CAS:
- 75225-50-2
Lovastatin Sodium is an HMG-CoA reductase inhibitor.
Formula:C₂₄H₃₈NaO₆
Color and Shape:Solid
Molecular weight:445.54
Ref: TM-T19918
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Crilvastatin
CAS:
- 120551-59-9
Crilvastatin (PMD 387) is an HMGCR inhibitor with cholesterol-lowering activity that inhibits cholesterol uptake in rats with hereditary hypercholesterolemia.
Formula:C₁₄H₂₃NO₃
Purity:98.69% - 99.54%
Color and Shape:Solid
Molecular weight:253.34
Ref: TM-T25276
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(Z)-Pitavastatin calcium
CAS:
- 1159588-21-2
(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.
Formula:C₅₀H₅₀CaF₂N₂O₈
Purity:98%
Color and Shape:Solid
Molecular weight:885.031
Ref: TM-T13380
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(3S,5R)-Pitavastatin calcium
CAS:
- 254452-88-5
(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
Formula:C₂₅H₂₆CaFNO₄
Purity:98%
Color and Shape:Solid
Molecular weight:463.562
Ref: TM-T10130
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(3S,5S)-Pitavastatin calcium
CAS:
- 254452-92-1
(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
Formula:C₂₅H₂₆CaFNO₄
Purity:98%
Color and Shape:Solid
Molecular weight:463.562
Ref: TM-T10132
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Simvastatin acid calcium hydrate
CAS:
- 530112-57-3
Simvastatin (Tenivastatin) calcium hydrate is an oral HMG-CoA reductase inhibitor that reduces ROS by blocking indoxyl sulfate.
Formula:C₂₅H₄₀O₆
Color and Shape:Solid
Molecular weight:436.28249
Ref: TM-T64292
+ Info
L 669262
CAS:
- 130468-11-0
L 669262 is a potent inhibitor of HMG-CoA reductase.
Formula:C₂₅H₃₆O₆
Color and Shape:Solid
Molecular weight:432.55
Ref: TM-T24323
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(3S,5R)-Fluvastatin sodium
CAS:
- 94061-81-1
(3S,5R)-Fluvastatin sodium: synthetic HMG-CoA reductase inhibitor, IC50 8 nM, boosts vascular cell antioxidant defense.
Formula:C₂₄H₂₆FNNaO₄
Purity:98%
Color and Shape:Solid
Molecular weight:434.463
Ref: TM-T10129
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2'-Ethyl Simvastatin
CAS:
- 79902-42-4
2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
Formula:C₂₃H₃₄O₅
Purity:98%
Color and Shape:Solid
Molecular weight:390.51
Ref: TM-T10070
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Dalvastatin
CAS:
- 132100-55-1
Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic
Formula:C₂₄H₃₁FO₃
Purity:98.80%
Color and Shape:Solid
Molecular weight:386.5
Ref: TM-T25285
+ Info
QH536
CAS:
- 2754254-07-2
QH536 degrades HMGCR (EC50: 0.22 μM), has anti-inflammatory properties, and avoids cholesterol buildup; useful for cardiovascular and NASH research.
Formula:C₃₃H₄₉N₃O₃
Color and Shape:Solid
Molecular weight:535.76
Ref: TM-T63777
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Bemfivastatin hemicalcium
CAS:
- 805241-64-9
Bemfivastatin hemicalcium (PPD 10558), an orally active HMG-CoA reductase inhibitor, serves as a lipid-lowering agent.
Formula:C₃₄H₃₆FN₂O₆Ca
Color and Shape:Solid
Molecular weight:607.67
Ref: TM-T82900
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L 668411
CAS:
- 112965-15-8
L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.
Formula:C₁₉H₃₀O₅
Purity:98%
Color and Shape:Solid
Molecular weight:338.44
Ref: TM-T24320

HMG-CoA Reductase

Found 32 products of "HMG-CoA Reductase"

Atorvastatin lactone

Ref: TM-T14342

Monacolin J

Ref: TM-T12092

Lipid Metabolism Compound Library

Ref: TM-L2510

(3S,5R)-Fluvastatin D6 sodium

Ref: TM-T10128

L 645164

Ref: TM-T24301

Ganoderenic acid K

Ref: TM-T75626

Rawsonol

Ref: TM-T26044

(Rac)-5-Keto Fluvastatin

Ref: TM-T12652

HMG-CoA Reductase-IN-1

Ref: TM-T79520

Atorvastatin calcium trihydrate

Ref: TM-T21363

Pravastatin lactone

Ref: TM-T37642

PPD 10558

Ref: TM-T28440

SR12813

Ref: TM-T6994

Clinofibrate

Ref: TM-T6450

7-Ketocholesterol

Ref: TM-TN6715

Simvastatin acid ammonium

Ref: TM-T16885

Tenivastatin

Ref: TM-T24865

Atorvastatin

Ref: TM-T20765

4-Acetylsimvastatin

Ref: TM-T10136

Lovastatin hydroxy acid sodium

Ref: TM-T19918

Crilvastatin

Ref: TM-T25276

(Z)-Pitavastatin calcium

Ref: TM-T13380

(3S,5R)-Pitavastatin calcium

Ref: TM-T10130

(3S,5S)-Pitavastatin calcium

Ref: TM-T10132

Simvastatin acid calcium hydrate

Ref: TM-T64292

L 669262

Ref: TM-T24323

(3S,5R)-Fluvastatin sodium

Ref: TM-T10129

2'-Ethyl Simvastatin

Ref: TM-T10070

Dalvastatin

Ref: TM-T25285

QH536

Ref: TM-T63777

Bemfivastatin hemicalcium

Ref: TM-T82900

L 668411

Ref: TM-T24320