Dehydrogenase
Dehydrogenases are enzymes involved in the oxidation-reduction reactions of metabolic pathways, playing a central role in energy production and cellular respiration. These enzymes are crucial for processes such as the citric acid cycle, glycolysis, and fatty acid oxidation. Dehydrogenase inhibitors are important tools in the study of metabolic diseases, cancer, and oxidative stress. At CymitQuimica, we provide a comprehensive selection of dehydrogenase inhibitors to support your research in metabolism, cancer biology, and biochemistry.
Found 300 products of "Dehydrogenase"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Formula:C22H18N4O5Color and Shape:SolidMolecular weight:418.4WQQ-345
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces α-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.Formula:C10H17NO2Color and Shape:SolidMolecular weight:183.25PDK-IN-1
CAS:PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Formula:C20H16BrN7OColor and Shape:SolidMolecular weight:450.29LDHA-IN-3
CAS:LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.Formula:C13H9F3SePurity:99.71%Color and Shape:SolidMolecular weight:301.17Ref: TM-T39805
1mg52.00€5mg113.00€10mg177.00€25mg371.00€50mg517.00€100mg707.00€200mg973.00€1mL*10mM (DMSO)124.00€Methyl Diethyldithiocarbamate
CAS:Methyl diethyldithiocarbamate, a disulfiram metabolite, inhibits rat ALDH (ID50=15.5mg/kg) and affects MAP and heart rate during ethanol challenge.Formula:C6H13NS2Color and Shape:SolidMolecular weight:163.311β-HSD1 inibitor 17
CAS:11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).Formula:C22H20F3N3O2SPurity:99.26% - 99.72%Color and Shape:SoildMolecular weight:447.47Crelosidenib
CAS:Crelosidenib is a potent and selective mutant IDH inhibitor for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutases.Formula:C28H36N6O3Purity:98.54%Color and Shape:SolidMolecular weight:504.62IGUANA-1 free base
CAS:IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.Formula:C26H24ClN3O2Color and Shape:SolidMolecular weight:445.94DSM1465
DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.Formula:C17H12ClF6N5O2Color and Shape:SolidMolecular weight:467.753Octanoyl Coenzyme A (sodium salt)
Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.Formula:C29H49N7NaO17P3SColor and Shape:SolidMolecular weight:915.71hDHODH-IN-13
CAS:hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications inColor and Shape:Soild11β-HSD1 inibitor 19
CAS:3-chloro-4-sulfonyl-Benzonitrile inhibits hHSD1/mHSD1, IC50: 16nM/10nM.Formula:C19H16ClF4N3O2SPurity:99.58%Color and Shape:SoildMolecular weight:461.86hDHODH-IN-17
hDHODH-IN-17 (Compound 10) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH), with an IC50 value of 0.188 μM. It fits well with the hDHODH active site and interacts effectively with amino acid residues. hDHODH-IN-17 is a potential broad-spectrum antiviral drug.MTHFD2-IN-1
MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Formula:C24H21NO6Color and Shape:SolidMolecular weight:419.43DHODH-IN-23
CAS:DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.
Formula:C24H21ClFNO4Purity:99.7%Color and Shape:SolidMolecular weight:441.88MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].Formula:C26H21F6N2NaO5Color and Shape:SolidMolecular weight:578.44PTOTAC HSD17B13 degrader 1
CAS:PTOTAC HSD17B13 Degrader 1, a PROTAC designed to target 17β-HSD 13 (HSD17B13), incorporates several key components. These include the PROTAC target protein ligand HSD17B13 Degrader 2, the PROTAC Linker tert-Butyl 5-bromoisoindoline-2-carboxylate, and the E3 ubiquitin ligase ligand E3 Ligase Ligand 31. Notably, the conjugate formed by the E3 ubiquitin ligase ligand and the linker is recognized as E3 Ligase Ligand-linker Conjugate 114.Formula:C45H45ClF3N7O5Color and Shape:SolidMolecular weight:856.33D-Lactate dehydrogenase
CAS:D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Color and Shape:SolidHSD17B13-IN-71
CAS:HSD17B13-IN-71 (Compound 149), an effective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), displays potent activity with an IC 50 value of ≤ 0.1 μM against estradiol. This compound is applicable in the study of various disorders including liver diseases, metabolic diseases, and cardiovascular conditions such as NAFLD or NASH, in addition to drug-induced liver injury (DILI) [1].Formula:C25H16Cl2F5N3O4Molecular weight:588.31Necroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formula:C12H17NOSPurity:99.85%Color and Shape:SoildMolecular weight:223.33LDHA-IN-8
CAS:LDHA-IN-8, an inhibitor, inhibits the proliferation of pancreatic and lung cancer cells, decreasing the intracellular lactate content and increasing ROS levels.Formula:C15H14N4O2Purity:99.73%Color and Shape:SolidMolecular weight:282.3SCD1 inhibitor-3
CAS:SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.Formula:C19H16FN7O2Purity:99.5%Color and Shape:SolidMolecular weight:393.37Ref: TM-T38683
1mg92.00€5mg187.00€10mg298.00€25mg507.00€50mg730.00€100mg1,026.00€1mL*10mM (DMSO)205.00€D34-919
CAS:D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.Formula:C22H27N5OSColor and Shape:SolidMolecular weight:409.55BMS-770767
CAS:BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.Formula:C19H18ClN3O2Color and Shape:SolidMolecular weight:355.82HSD17B13-IN-89
CAS:HSD17B13-IN-89 (206) acts as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13) and demonstrates potent activity with an IC 50 value of less than 0.1 μM for Estradiol. It is commonly utilized in research related to Nonalcoholic Fatty Liver Diseases (NAFLD) [1].Formula:C23H13Cl2F4N3O3Color and Shape:SolidMolecular weight:526.27PDK-IN-2
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.Formula:C17H23AsCl2N2O2S2Color and Shape:SolidMolecular weight:497.33DSM705
CAS:DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.Formula:C19H19F3N6OColor and Shape:SolidMolecular weight:404.397Glucose dehydrogenase
CAS:Glucose dehydrogenase (GDH) is a redox enzyme typically occurring as dimeric or tetrameric proteins. GDH utilises external NAD or NADP to oxidise glucose .Color and Shape:SolidALDH1A2-IN-1
CAS:ALDH1A2-IN-1 is a reversible active-site-directed ALDH1A2 inhibitor preventing spermatogenesis, useful in male contraceptive research.Formula:C21H26N4O4SPurity:99.51%Color and Shape:SolidMolecular weight:430.52Ref: TM-T39675
1mg50.00€5mg110.00€10mg172.00€25mg344.00€50mg537.00€100mg780.00€200mg1,054.00€1mL*10mM (DMSO)126.00€BMS-566419
CAS:BMS-566419: Acridinone-based IMPDH inhibitor for studying graft rejection.Formula:C28H30FN5O2Color and Shape:SolidMolecular weight:487.57DSM502
CAS:DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.Formula:C16H16F3N3OPurity:99.52%Color and Shape:SolidMolecular weight:323.31Ref: TM-T40087
1mg82.00€5mg177.00€10mg285.00€25mg583.00€50mg853.00€100mg1,161.00€1mL*10mM (DMSO)197.00€Aldehyde dehydrogenase (NAD(P))
CAS:ALDH catalyzes oxidation of aldehydes to acids, reducing NAD(P) to NAD(P)H, helping alleviate aldehyde stress.Color and Shape:SolidDSM265
CAS:DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity.DSM265 can be used for the treatment of malaria infections.Formula:C14H12F7N5SPurity:99.79%Color and Shape:SolidMolecular weight:415.332-Bromoacetamide
CAS:2-Bromoacetamide (α-Bromoacetamide) is a class of disinfection by-products that exhibit developmental toxicity in animals.Formula:C2H4BrNOPurity:99.83%Color and Shape:SolidMolecular weight:137.96Ketogestin
CAS:Ketogestin is a progestational steroid and an inhibitor of enzyme 11β-hydroxysteroid dehydrogenase, and a weak negative modulator of GABAA receptors.Formula:C21H28O3Purity:99.19%Color and Shape:SolidMolecular weight:328.45PKUMDL-WQ-2201
CAS:PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II.Formula:C15H14ClN3O3SColor and Shape:SolidMolecular weight:351.81ALDH1A3-IN-1
CAS:ALDH1A3-IN-1 (Compound 14) is a potent inhibitor of ALDH1A3 which can be used in prostate cancer research (IC50 = 0.63 μM; Ki = 0.46 μM) [1].Formula:C13H18BrNOColor and Shape:SolidMolecular weight:284.19PS10
CAS:PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Formula:C14H13NO6SPurity:98.51% - 99.01%Color and Shape:SolidMolecular weight:323.32ALDH3A1-IN-1
CAS:ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with IC50 of 1.61 μM, outperforms DEAB in prostate cancer cells.Formula:C13H18N2O3Purity:99.86%Color and Shape:SolidMolecular weight:250.29ABT-384
CAS:ABT-384 is a high-affinity, selective 11β-HSD1 inhibitor capable of suppressing hepatic and central nervous system HSD-1 activity for depressive disorder.Formula:C25H34F3N5O2Purity:99.863%Color and Shape:SolidMolecular weight:493.58Ref: TM-T26528
1mg109.00€5mg260.00€10mg432.00€25mg802.00€50mg1,243.00€100mg1,935.00€200mg2,592.00€1mL*10mM (DMSO)281.00€4-Isopropoxybenzaldehyde
CAS:ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.Formula:C10H12O2Purity:99.00%Color and Shape:SolidMolecular weight:164.2Brequinar
CAS:Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.Formula:C23H15F2NO2Purity:99.1% - 99.57%Color and Shape:SolidMolecular weight:375.37VER-246608
CAS:VER-246608 inhibits PDK (IC50: 35-91 nM), boosts PDC, reduces glycolysis, causes cancer cell cytostasis, and enhances doxorubicin effects.Formula:C28H23ClF2N4O4Purity:98.5%Color and Shape:SolidMolecular weight:552.96Ref: TM-T17224
1mg50.00€2mg71.00€5mg105.00€10mg166.00€25mg313.00€50mg475.00€100mg692.00€1mL*10mM (DMSO)130.00€BVT 2733
CAS:BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.Formula:C17H21ClN4O3S2Purity:98% - 99.64%Color and Shape:SolidMolecular weight:428.96Vidofludimus hemicalcium
CAS:Vidofludimus hemicalcium: oral DHODH inhibitor, FXR modulator, for autoimmune and fatty liver research.Formula:C20H18FNO4CaColor and Shape:SolidMolecular weight:375.4NCT-503
CAS:NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with no activity against other dehydrogenases. NCT-503 has antitumor activity. Cost-effective and quality-assured.Formula:C20H23F3N4SPurity:98.91% - 99.84%Color and Shape:SolidMolecular weight:408.48Ref: TM-T4213
2mg39.00€5mg59.00€10mg95.00€25mg177.00€50mg321.00€100mg477.00€200mg667.00€1mL*10mM (DMSO)65.00€(E/Z)-Teriflunomide
CAS:(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.Formula:C12H9F3N2O2Purity:99.49% - 99.76%Color and Shape:White SolidMolecular weight:270.21AGI-6780
CAS:AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.Formula:C21H18F3N3O3S2Purity:98.19% - 99.7%Color and Shape:SolidMolecular weight:481.51Ref: TM-T1809
1mg34.00€2mg49.00€5mg74.00€10mg113.00€25mg208.00€50mg371.00€100mg557.00€500mg1,198.00€1mL*10mM (DMSO)80.00€NCT-505
CAS:NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 withFormula:C27H28FN5O3SPurity:99.93%Color and Shape:SolidMolecular weight:521.61Ref: TM-T12196
1mg109.00€5mg224.00€10mg334.00€25mg532.00€50mg718.00€100mg964.00€200mg1,288.00€1mL*10mM (DMSO)256.00€R162
CAS:R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.Formula:C17H12O3Purity:96.21% - 98.15%Color and Shape:SolidMolecular weight:264.28
