VER-246608

CAS: 1684386-71-7

Ref. TM-T17224

Product Information

• Name: VER-246608
• Synonyms: VER246608
• CAS: 1684386-71-7

Description

VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.

• Brand: Targetmol

Chemical properties

• Molecular weight: 552.96
• Formula: C₂₈H₂₃ClF₂N₄O₄
• Purity: 98.88%
• Color/Form: Solid
• InChI: InChI=1S/C28H23ClF2N4O4/c1-16-13-33-28(29)34-24(16)19-6-8-20(9-7-19)35(27(39)22-11-10-21(36)12-23(22)37)15-18-4-2-17(3-5-18)14-32-26(38)25(30)31/h2-13,25,36-37H,14-15H2,1H3,(H,32,38)
• InChI key: InChIKey=LCGNLQSOSJFLKR-UHFFFAOYSA-N
• SMILES: Cc1cnc(Cl)nc1-c1ccc(N(Cc2ccc(CNC(=O)C(F)F)cc2)C(=O)c2ccc(O)cc2O)cc1