PKM
Pyruvate Kinase M2 (PKM) is an isoform of pyruvate kinase that plays a crucial role in glycolysis, converting phosphoenolpyruvate to pyruvate. PKM2 is involved in the regulation of metabolic reprogramming in cancer cells, making it a potential target for cancer therapy. Inhibitors of PKM2 can alter metabolic pathways, reduce tumor growth, and induce cell death in cancer cells. At CymitQuimica, we provide PKM2 inhibitors to support your research in cancer metabolism, oncology, and therapeutic development.
Found 17 products of "PKM"
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PKR-IN-2
CAS:PKR-IN-2 is a activator of pyruvate kinase (PKR).Formula:C24H28N4O4SPurity:99.14%Color and Shape:SolidMolecular weight:468.57Ref: TM-T12499
1mg81.00€5mg145.00€10mg207.00€25mg334.00€50mg467.00€100mg655.00€200mg883.00€1mL*10mM (DMSO)149.00€Dimethylaminomicheliolide HCl
CAS:Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvateFormula:C17H28ClNO3Purity:99.91%Color and Shape:SoildMolecular weight:329.86PKM2 inhibitor G
CAS:PKM2 inhibitor G is a inhibitor of pyruvate kinase.Formula:C16H15NO3SPurity:99.89%Color and Shape:SoildMolecular weight:301.36Ref: TM-T67900
1mg109.00€5mg243.00€10mg355.00€25mg532.00€50mg745.00€100mg1,018.00€1mL*10mM (DMSO)230.00€PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Formula:C16H19F3O4Molecular weight:332.12354PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Formula:C21H15F4N5Color and Shape:SolidMolecular weight:413.12636PKCζ/ι pseudosubstrate inhibitor
CAS:PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFormula:C76H128N30O16Color and Shape:SolidMolecular weight:1718.02Mitapivat sulfate hydrate
CAS:Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.Formula:C24H26N4O3S1H2SO43H2OPurity:99.22%Color and Shape:SolidMolecular weight:526.6DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Formula:C19H23N3O6S2Purity:96.96% - 99.28%Color and Shape:SolidMolecular weight:453.53Mitapivat
CAS:Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Formula:C24H26N4O3SPurity:99.47% - 99.83%Color and Shape:SolidMolecular weight:450.55PKM2-IN-1
CAS:PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Formula:C18H19NO2S2Purity:99.49% - 99.68%Color and Shape:SolidMolecular weight:345.48TEPP-46
CAS:TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Formula:C17H16N4O2S2Purity:98.21% - 99.65%Color and Shape:SolidMolecular weight:372.46Ref: TM-T7214
1mg48.00€5mg96.00€10mg144.00€25mg235.00€50mg354.00€100mg528.00€500mg1,159.00€1mL*10mM (DMSO)96.00€PKM2 activator 5
CAS:PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Formula:C18H19FN2O6S2Purity:98%Color and Shape:SolidMolecular weight:442.48PKM2 activator 2
CAS:PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates
Formula:C20H18F2N2O4S2Purity:99.92%Color and Shape:SolidMolecular weight:452.49NPD10084
CAS:NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with β-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].Formula:C21H19N3O2Color and Shape:SolidMolecular weight:345.39Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.457PKR Inhibitor, negative control
CAS:The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Formula:C15H8Cl3NO2Molecular weight:340.59
