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PKM

PKM

Pyruvate Kinase M2 (PKM) is an isoform of pyruvate kinase that plays a crucial role in glycolysis, converting phosphoenolpyruvate to pyruvate. PKM2 is involved in the regulation of metabolic reprogramming in cancer cells, making it a potential target for cancer therapy. Inhibitors of PKM2 can alter metabolic pathways, reduce tumor growth, and induce cell death in cancer cells. At CymitQuimica, we provide PKM2 inhibitors to support your research in cancer metabolism, oncology, and therapeutic development.

Found 15 products of "PKM"

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  • PKR-IN-2
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    PKR-IN-2

    CAS:
    <p>PKR-IN-2 is a activator of pyruvate kinase (PKR).</p>
    Formula:C24H28N4O4S
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:468.57

    Ref: TM-T12499

  • PKCζ/ι pseudosubstrate inhibitor
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    PKCζ/ι pseudosubstrate inhibitor

    CAS:
    <p>PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction of</p>
    Formula:C76H128N30O16
    Color and Shape:Solid
    Molecular weight:1718.02

    Ref: TM-T80071

  • Dimethylaminomicheliolide HCl
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    Dimethylaminomicheliolide HCl

    CAS:
    <p>Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate</p>
    Formula:C17H28ClNO3
    Purity:99.55%
    Color and Shape:Soild
    Molecular weight:329.86

    Ref: TM-T60102L

  • CymitQuimica logo
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    PKM2-IN-10

    <p>PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.</p>
    Formula:C21H15F4N5
    Color and Shape:Solid
    Molecular weight:413.12636

    Ref: TM-T207198

  • PKM2 inhibitor G
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    PKM2 inhibitor G

    CAS:
    <p>PKM2 inhibitor G is a inhibitor of pyruvate kinase.</p>
    Formula:C16H15NO3S
    Purity:99.89%
    Color and Shape:Soild
    Molecular weight:301.36

    Ref: TM-T67900

  • Mitapivat sulfate hydrate
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    Mitapivat sulfate hydrate

    CAS:
    <p>Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.</p>
    Formula:C24H26N4O3S1H2SO43H2O
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:526.6

    Ref: TM-T69865

  • DASA-58
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    DASA-58

    CAS:
    <p>DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.</p>
    Formula:C19H23N3O6S2
    Purity:96.96% - 99.28%
    Color and Shape:Solid
    Molecular weight:453.53

    Ref: TM-T6816

  • Mitapivat
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    Mitapivat

    CAS:
    <p>Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.</p>
    Formula:C24H26N4O3S
    Purity:99.47% - 99.83%
    Color and Shape:Solid
    Molecular weight:450.55

    Ref: TM-T4223

  • PKM2-IN-1
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    PKM2-IN-1

    CAS:
    <p>PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.</p>
    Formula:C18H19NO2S2
    Purity:99.49% - 99.68%
    Color and Shape:Solid
    Molecular weight:345.48

    Ref: TM-T4170

  • TEPP-46
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    TEPP-46

    CAS:
    <p>TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.</p>
    Formula:C17H16N4O2S2
    Purity:98.21% - 98.77%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T7214

  • PKM2 activator 5
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    PKM2 activator 5

    CAS:
    <p>PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.</p>
    Formula:C18H19FN2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:442.48

    Ref: TM-T72693

  • PKM2 activator 2
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    PKM2 activator 2

    CAS:
    <p>PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates</p>
    Formula:C20H18F2N2O4S2
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:452.49

    Ref: TM-T62758

  • PKM2-IN-9
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    PKM2-IN-9

    CAS:
    <p>PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.</p>
    Formula:C24H22N4O2
    Color and Shape:Solid
    Molecular weight:398.457

    Ref: TM-T204898

  • Mitapivat hydrochloride
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    Mitapivat hydrochloride

    CAS:
    <p>Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.</p>
    Formula:C24H27ClN4O3S
    Color and Shape:Solid
    Molecular weight:487.014

    Ref: TM-T206172

  • CymitQuimica logo
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    PKR Inhibitor, negative control

    CAS:
    <p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>
    Formula:C15H8Cl3NO2
    Molecular weight:340.59

    Ref: TM-T209999