PKM
Pyruvate Kinase M2 (PKM) is an isoform of pyruvate kinase that plays a crucial role in glycolysis, converting phosphoenolpyruvate to pyruvate. PKM2 is involved in the regulation of metabolic reprogramming in cancer cells, making it a potential target for cancer therapy. Inhibitors of PKM2 can alter metabolic pathways, reduce tumor growth, and induce cell death in cancer cells. At CymitQuimica, we provide PKM2 inhibitors to support your research in cancer metabolism, oncology, and therapeutic development.
Found 20 products for "PKM".
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PKR-IN-2
CAS:PKR-IN-2 is a activator of pyruvate kinase (PKR).Formula:C24H28N4O4SPurity:99.14%Color and Shape:SolidMolecular weight:468.569PKCζ/ι pseudosubstrate inhibitor
CAS:PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFormula:C76H128N30O16Color and Shape:SolidMolecular weight:1718.02NCGC00188636
CAS:NCGC00188636 is a covalent pyruvate kinase (PYK) inhibitor; blocks nucleotide binding at the active site; used for metabolism and parasite research.Formula:C14H9NO4S2Purity:99.38%Color and Shape:White SolidMolecular weight:319.36ML 083
CAS:ML 083 is an allosteric activator of tumor-associated pyruvate kinase M2, used to study cancer-specific glycolytic regulation and metabolic reprogramming.Formula:C19H22N2O7S2Purity:99.99%Color and Shape:White SolidMolecular weight:454.52PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Formula:C16H19F3O4Molecular weight:332.12354PKM2 inhibitor G
CAS:PKM2 inhibitor G is a inhibitor of pyruvate kinase.Formula:C16H15NO3SPurity:99.89%Color and Shape:SolidMolecular weight:301.36Ref: TM-T67900
1mg109.00€1mL*10mM (DMSO)230.00€5mg242.00€10mg355.00€25mg532.00€50mg745.00€100mg1,017.00€Vitamin K5 hydrochloride (Standard)
CAS:Vitamin K5 hydrochloride (Standard) is a reference standard for research and analysis in studies involving Vitamin K5 hydrochloride. Vitamin K5 (hydrochloride), a naphthoquinone compound, exhibits trichomonacidal activity in vitro and can be utilized for anti-infection research [1].Formula:C11H12ClNOMolecular weight:209.67PKM2-IN-1
CAS:PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Formula:C18H19NO2S2Purity:99.49% - 99.68%Color and Shape:SolidMolecular weight:345.479TEPP-46
CAS:TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Formula:C17H16N4O2S2Purity:95.54% - 99.65%Color and Shape:SolidMolecular weight:372.47Ref: TM-T7214
1mg45.00€5mg100.00€1mL*10mM (DMSO)100.00€10mg137.00€25mg223.00€50mg335.00€100mg500.00€500mg1,098.00€Mitapivat
CAS:Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Formula:C24H26N4O3SPurity:99.47% - 99.94%Color and Shape:SolidMolecular weight:450.553DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Formula:C19H23N3O6S2Purity:96.96% - 99.28%Color and Shape:SolidMolecular weight:453.53PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Formula:C21H15F4N5Color and Shape:SolidMolecular weight:413.12636PKM2 activator 5
CAS:PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Formula:C18H19FN2O6S2Purity:98%Color and Shape:SolidMolecular weight:442.482PKM2 activator 2
CAS:PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuatesFormula:C20H18F2N2O4S2Purity:99.92%Color and Shape:SolidMolecular weight:452.495Ref: TM-T62758
1mg53.00€5mg114.00€1mL*10mM (DMSO)126.00€10mg185.00€25mg334.00€50mg505.00€100mg760.00€500mg1,512.00€NPD10084
CAS:NPD10084 is an inhibitor that targets the pyruvate kinase M2 subtype (PKM2).Formula:C21H19N3O2Purity:99.34%Color and Shape:SolidMolecular weight:345.3945Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014PKR Inhibitor, negative control
CAS:The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Formula:C15H8Cl3NO2Molecular weight:340.59Vitamin K5 hydrochloride
CAS:Vitamin K5 hydrochloride is a photosensitizer and antimicrobial agent that functions as a specific inhibitor of pyruvate kinase M2 (PKM2), with IC50 values of 28 μM for PKM2, 191 μM for PKM1, and 120 μM for PKL. Vitamin K5 hydrochloride induces apoptosis in colon 26 cells, supporting its application in infection and cancer research as well as its practical use as a preservative in pharmaceutical, food, and beverage formulations.Formula:C11H12ClNOColor and Shape:SolidMolecular weight:209.67PKM2 agonist-1
CAS:PKM2 agonist-1 (Compound D16) is a potent allosteric activator of PKM2, with an AC50 value of 77 nM. It inhibits angiotensin II-induced smooth muscle cell phenotypic transformation, effectively preventing aortic dissection and reducing mortality.Formula:C24H23N5O4S2Molecular weight:509.6PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.4571
