Microbiology/Virology

<p>16-Keto Aspergillimide (SB202327) is a novel anthelmintic compound derived from the Aspergillus strain IMI 337664.</p>

<p>This peptide is a H-2Kd-restricted epitope from Influenza nucleoprotein (147-155).</p>

<p>Z-Leu-Arg-AMC: a leucine-4-methylcoumarinyl amide marked with carboxybenzoyl, key for trypanopain-Tb in T. brucei.</p>

<p>A 21960, or Ethyl 2-chloroacetoacetate, blocks synapse formation and site-specific recombination, aiding in bacterial infection research.</p>

<p>Destomycin A, an aminoglycoside antibiotic, exhibits activity against bacterial (Gram-positive and Gram-negative), antifungal, and anthelmintic agents. It inhibits peptide synthesis in Escherichia coli cells and stimulates adenylate cyclase in animal tissues.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>2,3-Dehydro-3,4-dihydro ivermectin is an ivermectin analog and anthelmintic, effective against L. amazonensis without harming macrophages.</p>

<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>

<p>Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.</p>

<p>Extracellular death factor TFA (EDF TFA) is a linear pentapeptide that communicating cells produce and release, which activates the cell death pathway.</p>

<p>Fosetyl-aluminum is a systemic fungicide that controls downy mildews and Phytophthora diseases, used on a variety of crops including fruits and vegetables。</p>

<p>Antiviralagent 65 (compound 9) is an antiviral agent targeting the H1N1 influenza virus, with an EC50 of 7 μg/mL.</p>

<p>HLA-B*08 restricted influenza virus nucleoprotein epitope.</p>

<p>Linearmycin A, a polyene antibiotic from Streptomyces, fights S. aureus, E. coli, S. cerevisiae, C. albicans, and A. niger with low MICs.</p>

<p>(E)-hexadec-11-en-1-ol is a pheromone of the spotted stem borer Chilo partellus and is a long-chain fatty acid found in the volatile oil of Daphne genkwa.</p>

<p>Amustaline (S-303) dihydrochloride is a nucleic acid alkylator useful for inactivating pathogens in blood with red cells.</p>

<p>WRN inhibitor 16 (Example 83) is an orally active WRN inhibitor. In a SW48 xenograft mouse tumor model, WRN inhibitor 16 did not cause tumor regression.</p>

<p>Agathisflavone is a NS2B-NS3 proteases inhibitor of the Dengue virus serotypes 2 and 3.</p>

<p>Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.</p>

<p>WRN inhibitor 18 (compound 306) is an orally active inhibitor of WRN with demonstrated anticancer activity in vivo.</p>

<p>Arbekacin is an aminoglycoside antibiotic.</p>

<p>MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.</p>

<p>Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.</p>

<p>Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>S1b3inL1 is a macrocylcic peptide inhibitor of the SARS-CoV-2 spike protein. It binds with high affinity to a conserved site on the spike protein, effectively suppressing the infection of various SARS-CoV-2 variants. S1b3inL1 exhibits antiviral activity.</p>

<p>Saframycin S, an antibiotic featuring a Racemomycin group, demonstrates inhibitory effects against Ehrlich ascites tumor. The LD50 value of Saframycin S in ddY mice is 3.2 mg/kg (i.p.).</p>

<p>Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>Obafluorin is a β-lactone antibiotic produced by fluorescent Pseudomonas ATCC 39502, with broad-spectrum antibacterial activity.</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>Spike protein mRNA for COVID-19 enables protein expression, assesses RNA delivery, translation, cell health, and is key for virus entry and vaccine targets.</p>

<p>Ascochin, an isocoumarin derivative and fungal metabolite identified in Ascochyta, demonstrates antimicrobial activity. At a concentration of 0.5 mg/disc, it inhibits Bacillus megaterium (the bacterium), Mycosphaerella violaceum (the plant pathogenic fungus), and Chlorella fusca (the alga) in agar diffusion assays.</p>

<p>Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly</p>

<p>Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits both antifungal and antibacterial properties by targeting</p>

<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>

<p>KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation.</p>

<p>Eprinomectin B1b is a minor component and belongs to the avermectin family of insecticides and anthelmintics.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>

<p>PD 116152: phenazine from Streptomyces with antitumor effects on P388 leukemia (T/C 149) and potent against Streptococcus pneumoniae (MIC &lt; 0.46 µg/ml).</p>

<p>Melarsomine is a trivalent arsenic drug used to treat canine heartworm and other worms. It's key in related research.</p>

<p>(R)-Dinotefuran, a neonicotinoid, is 1.7-2.4x more effective against pests like Aphis gossypii and safer for bees.</p>

<p>1-Phenylhexane exhibits antibacterial and antioxidant activity, inhibiting S. aureus, Pseudomonas aeruginosa, Proteus mirabilis, E. coli, and Bacillus cereus</p>

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>

<p>Carbomycin B, a precursor in making Carbomycin, is a macrolite antibiotic from Stroptomyces halstedii, akin to Leucomycin and Erythromycin.</p>

<p>Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C.</p>

<p>Vaborbactam ammonium salt is a β-lactamase inhibitor that restores carbapenem activity against KPC-producing strains.</p>

<p>Cefluprenam is a a cephalosporin type antibacterial agent.</p>

<p>5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.</p>

<p>(±)15-HEPE is a racemic mixture of monohydroxy fatty acids 15 (R) -HEPE and 15 (S) -HEPE, with antibacterial activity.</p>

<p>Bacteria use quorum sensing with autoinducers like AHLs to regulate gene expression and behaviors such as biofilm formation.</p>

<p>3-Deaza-2'-deoxyadenosine inhibits lymphocyte cytolysis at 100 μM with low toxicity; aids in studying adenine N3 in DNA.</p>

<p>Influenza HA (518-526) is an immunodominant epitope in H2d mice after flu virus infection.</p>

<p>Cytosporone C, from Diaporthe eucalyptorum fungus, is an antifungal that combats Alternaria solani.</p>

Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting bacterial and fungal growth.

<p>NCGC00537446 is a dual inhibitor of Nsp14 MTase/ExoN. It is applicable for research on SARS-CoV-2 replication and infection.</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>Bulevirtide (Myrcludex B) inhibits HBV/HDV entry into hepatocytes, treating chronic hepatitis D.</p>

<p>Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.</p>

<p>Antibacterial agent 136, an oxadiazolone antibiotic, highly potent against MRSA with MIC 50 at 0.8 μM.</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>Raxibacumab (ABthrax) is a humanized antibody targeting the protective antigen of Bacillus anthracis, with anti-infection activity.</p>

<p>(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>

<p>Romlusevimab (BRII-198) is a recombinant antibody targeting the spike protein of SARS-CoV-2, with antiviral activity.</p>

<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>

<p>Odesivimab (REGN-3471) is a human monoclonal antibody against Zaire Ebola virus, with potential antiviral activity.</p>

<p>UCM53 has a wide range of applications in life science related research.</p>

<p>Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>Anguinomycin A, an antibiotic from Streptomyces, is like leptomycin B, kills mouse leukemia cells, and fights lung cancer in mice.</p>

<p>Isosulfazecin is a beta-lactam antibiotic.</p>

<p>(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.</p>

<p>Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.</p>

<p>Chamaejasmenin D is a useful organic compound for research related to life sciences and the catalog number is T124064.</p>

<p>Formycin B is a model nucleoside analog.</p>

<p>Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.</p>

<p>Wychimicin A, from Actinocrispum wychmicini MI503-AF4, is a potent antibacterial against MRSA and Enterococcus. (IC50=0.125-0.5μg/mL).</p>

<p>β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.</p>

<p>Dicresulene diammonium is an impurity found in Policresulen, which is an organic acid possessing hemostatic, antimicrobial, and antiviral properties[1][2].</p>

<p>Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1].</p>

<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>

<p>SPR741, a cationic peptide from polymyxin B, is being developed to treat serious Gram-negative infections.</p>

<p>2-Phenoxyphenol has antibacterial against Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, Burkholderia pseudomallei, etc.</p>

<p>Carnaubadiol, a triterpene from E. corollata, inhibits L. infantum and T. cruzi with IC50s: 46.2, 7.8, 14.9 μM.</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>Cephabacin M4 is a new cephem antibiotic isolated from bacterial.</p>

<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>

<p>Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.</p>

<p>Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing</p>

<p>Maximin H1, an antimicrobial peptide sourced from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits efficacy against several</p>

<p>Ivermectin B1b, minor antiparasitic, binds to nematode glutamate channels, causing lasting hyperpolarization and paralysis.</p>

<p>2-Benzylaniline is a potential Cytochrome P450 2B6 inhibitor with an IC50 value of 4.36 μM.</p>