Microbiology/Virology

AB-836, an orally active hepatitis B virus (HBV) capsid inhibitor, hampers viral replication by engaging with the HBV core protein.

DprE1-IN-9 (compound B18) is an efficient reversible inhibitor of DprE1, interacting with the enzyme's receptor cavity.

Antifungal agent 77 (Compound 13h) exhibits not only antifungal properties, but also effective insecticidal activity against Mythimna separata, Helicoverpa

HBV-IN-30, a flavone derivative, inhibits cccDNA in HBV research.

Berkeleylactone E, a macrolide antibiotic [1], exhibits antimicrobial properties.

HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy

Antifungal agent 49 (Example 112) exhibits activity against Cryptococcus neoformans, demonstrating a minimum inhibitory concentration (MIC) of 49 μM [1].

NS5A-IN-3 is a potent NS5A inhibitor with high efficacy against HCV 1b, good activity on 3a, and strong metabolic stability; superior to daclatasvir.

UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.

SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), exhibiting potent inhibitory activity with an IC50 of 3.8 nM and

Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and

Prochloraz manganese, an antifungal agent utilized in the agricultural sectors [1], serves to protect crops by inhibiting fungal growth.

Besifovir Dipivoxil maleate, an oral HBV prodrug (LB80380), suppresses HBV DNA in naive and lamivudine-resistant CHB cases.

NSC309401 is an E. coli dihydrofolate reductase inhibitor with an IC50 value of 189 nM and a dissociation constant (Kd) of 14.57 nM [1].

AU1235 is a Mycobacterium tuberculosis inhibitor.

RCB16007 is a Yellow Fever Virus (YFV) inhibitor that also demonstrates inhibitory action against the West Nile virus with an effective concentration (EC50) of

Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the

PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivo

BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).

Antibiofilm agent-9 (Compound 4), a derivative of pyrrolnitrin, exhibits antimicrobial activity. It inhibits Bacillus anthracis with a Minimum Inhibitory Concentration (MIC) of 0.031 μg/mL. The compound demonstrates significant antibiofilm activity, achieving an inhibition rate of 84% after 24 hours at a concentration of 8.0 μg/mL. Additionally, Antibiofilm agent-9 shows favorable pharmacokinetic properties in mouse models.

ELQ-596, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice [1].

Antituberculosis agent-6: potent against M. tuberculosis (MIC 3.49 μM), antifungal (MIC 62.5 μM), high GI absorption.

12-Bromododecanoic acid, a halogenated derivative of lauric acid, serves in the synthesis of clickable myristic acid derivatives and functions as a model fatty acid ligand for elucidating the X-ray crystal structure of bovine β-lactoglobulin-ligand complexes. This compound, at a concentration of 10 µg/ml, has been shown to diminish virion DNA in the culture supernatant of primary hepatocytes from a duckling model of hepatitis B virus (HBV) infection and exhibits inhibitory activity against HIV replication in CEM-SS T cells with an EC50 value of 38 µM.

Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent.

Sulfachloropyridazine (sodium) is a sulfonamide antibiotic that impedes bacterial proliferation [1].

DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.

Zika virus-IN-3 (Compd 7) is a Zika virus inhibitor, with an EC 50 of 3.4 μM [1].

Sphinganine (d16:0 branched), an aniso-branched sphingolipid, is identified as a constituent of ceramide-containing phospholipids in bacteria.

ASN 07115873 is an anti-Zika virus (ZIKV) compound with an inhibitory concentration (IC50) of 189.2 picomolar (pM), suitable for antiviral research [1].

DXR inhibitor 11a, with an IC50 of 0.11 µM, effectively inhibits P.

SHR5133 is a potent, orally active regulator of HBV capsid assembly that reduces HBV DNA (EC50: 26.6 nM).

A 74704 is a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog.

Berlopentin is splenopentin analog used to treat HIV-positive patients. It also has immunostimulatory properties.

DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.

Peptide 46 is a short peptide that inhibits SC-dependent DNA synthesis by targeting the bacterial sliding clamp (SC).

AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.

Byssochlamic acid, a mycotoxin identified in the agricultural fungal pathogen B. fulva, exhibits lethality in mice with an LD50 of 94 mg/kg.

Droxinavir HCl is an antiviral agent and HIV protease inhibitor.

NIK-250 is a P-glycoprotein inhibitor. NIK250 could reverse multidrug resistance in human glioma cells.

NEU-730, a novel inhibitor of TbrPDEB1, shows modest inhibition of T. brucei proliferation.

SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM.

3′-Deoxy Thymidine is a nucleoside analog of thymidine with antiviral activity. 3′-Deoxy Thymidine inhibit HIV replication in peripheral blood mononuclear cells (EC50 = 0.17 µM). 3′-Deoxy Thymidine also decreases plaque formation in CV-1 cells infected with HSV-1 at micromolar concentrations. These properties support the use of 3′-Deoxy Thymidine in antiviral mechanism studies and nucleoside analog evaluation.

Rp-dGTPαS, an enantiomer of the dNTPαS nucleotide, serves as the substrate for SAMHD1, a critical regulator of cellular dNTP levels that curtails the replication of viruses (HIV-1, etc.) in CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex facilitates the hydrolysis of Rp-dGQTPαS into 2'-deoxynucleosides and triphosphates [1].

DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.

SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (IC50) of 7.2 μg/mL and an

XSJ2-46, a 5'-amino NI analog, is an antiviral agent possessing anti-Zika virus properties and demonstrates reasonable inhibition of RNA-dependent RNA

RSV L-protein-IN-3 is an inhibitor of the wild-type RSV polymerase, exhibiting an IC50 of 10.4 μM and an EC50 of 2.1 μM (against RSV), and possesses lower

Antibacterial 91: Inhibits aaRS, IC50 2.10μM vs. S. enterica ThrRS, has antibacterial properties. [1]

RSV L-protein-IN-5 (Compound E) serves as a potent inhibitor of the Respiratory Syncytial Virus (RSV), with an EC50 value of 0.1 μM.

Oxynitidine, an HBV inhibitor (ID50 = 30.8 µg/mL), effectively suppresses HBV DNA replication and may be utilized in viral infection research [1].

LY 173013 is a bicyclic pyrazolidinone, it has antibacterial properties.

Acorafloxacin: broad-spectrum fluoroquinolone antibacterial for acute skin infections and pneumonia.

CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.

Tirapiravir is an antiviral nucleoside analog that exhibits activity against both the novel coronavirus and influenza virus [1].

FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,

SW106 blocks PTHR1 cAMP signaling, not affecting mutant PTHR1-T410P/H223R.

Limocrocin is an inhibitor of reverse transcriptase.

Phylloflavan, an antileishmanial compound, exhibits an intracellular half maximal effective concentration (EC50) of 3.2 nM in RAW 264.7 cells and inhibits the

Palinavir is an antiviral, it inhibits HIV-1 protease.

NSC15520 is an RPA inhibitor that inhibits helical destabilization of double-stranded DNA oligonucleotides and can be used to study DNA damage repair.

Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.

Antibiofilm Agent-2 (Compound 4T) serves as a potent biofilm inhibitor, exhibiting an IC50 of 3.6 μM, and impairs the quorum sensing system along with iron

PD 121373, a Benzothiopyrano-indazole, inhibits nucleic acid synthesis, equally affecting DNA/RNA.

Avarol triggers cell death in pancreatic cancer and is a non-toxic, neuroprotective AChE inhibitor for Alzheimer's.

VT-1598 is a novel, selective, orally active fungal CYP51 inhibitor. VT-1598 exhibits antifungal effects against Candida albicans.

Compound 17b, an amino alcohol-quinoline, targets Pf3D7 (IC50: 14.9 nM) and PfW2 (IC50: 11 nM) with selectivity index >770.

Teropavimab (3BNC117-LS), an antibody, is utilized in the research of HIV infection [1].

WRNA10 is a potent binding agent for HIV-1TAR RNA (IC50: 10 μM, CC50: 40 μM).

HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-

Anti-Trypanosoma cruzi agent-3 is an antiprotozoal agent.

1R-cis-Permethrin, an insecticide and neurotoxin, acts on neuron membranes by extending the activation of sodium channels [1].

ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).

Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound.

WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].

5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

3β-Hydroxy-hop-22(29)-ene is a potent antiparasitic compound demonstrating moderate efficacy against Trypanosoma cruzi and Leishmania mexicana.

Frenolicin is a selective inhibitor of Prx1 and Grx3 through covalent modification of active-site cysteines.

L 694746 is an inhibitor of HIV-1 protease.

EDI048 is an orally active Cryptosporidium PI4K inhibitor, which can be used in the research of cryptosporidiosis.

Antiviral agent 27 (Compound 12) exhibits significant activity against the Ebola virus, with an EC50 value of 14 nM [1].

RyRs activator 2: potent ranibulin receptor stimulant, 30% larvicidal activity, equals chlorfenvinphos, outperforms cyanobenzamide.

RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.

GSK-3532795: a broader-spectrum HIV-1 maturation inhibitor than bevirimat, effective in vitro and clinically.

Phenethicillin sodium (α-Phenoxyethylpenicillin) is a penicillin-class antibiotic that exhibits antimicrobial activity [1].

Icofungipen is an oral antifungals with active against Candida species.

Myxopyronin A is an inhibitor of bacterial RNA polymerase.

Antibacterial Agent 154 (Compound 7), a Fluoroquinolone derivative, exhibits broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria when

KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.

Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting the

HIV-1 inhibitor-3 is an HIV infection inhibitor.

MAC13772 is a potent inhibitor of the enzyme BioA with an IC50 of 250 nM thereby inhibiting biotin biosynthesis. MAC13772 exhibits antibacterial activity.

HOE961, a diacetate ester prodrug of S2242, is an oral anti-orthopoxvirus agent effective against cowpox.

Tobevibart, an IgG1-lambda humanized monoclonal antibody targeting the hepatitis B virus (HBV) surface envelope protein, exhibits antiviral activity [1].