Microbiology/Virology

<p>Arylomycin A4 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>A 16316-C is a water soluble basic antibiotic, it is isolated from Streptoverticillium eurocidicus.</p>

<p>Polyunsaturated anacardic acid diene from cashew shells fights MRSA, S. mutans, and S. mansoni; inhibits soybean lipoxygenase-1.</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>Lettowienolide is a natural product that can be used as a reference standard.</p>

<p>This peptide is a H2-Db-restricted epitope from Influenza nucleoprotein (147-155).</p>

<p>Spinosad Factor D is a naturally derived fermentation product. It is used as a pesticide against many different insects.</p>

<p>Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.</p>

<p>β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.</p>

<p>DENV ligand 2 is a ligand for the DENV E protein. It is used in the synthesis of the PROTAC degrader ZXH-8-004 and serves as the active form of DENV ligand 1.</p>

<p>VIR-165, a derivative of VIRIP (353-372 of alpha1-antitrypsin), blocks several HIV-1 strains.</p>

<p>Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria.</p>

<p>Psoracorylifol B is a natural product that can be used as a reference standard.</p>

<p>REGN3051 is a human IgG1 monoclonal antibody (mAb) that targets MERS CoV. It has been shown to reduce lung viral titers in mice expressing human DPP4 and to decrease disease severity and viral replication in the lungs of MERS-CoV infected marmosets. The recommended isotype control is HumanIgG1kappa, Isotype Control.</p>

<p>PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).</p>

<p>Cardoldiene is a natural product that can be used as a reference standard. The CAS number of Cardoldiene is 79473-25-9.</p>

<p>Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1].</p>

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

<p>M7GpppAmpG is a trinucleotide 5′ cap analog, exhibiting capping efficiencies of 90% for the produced RNAs [1].</p>

<p>Inostamycin A sodium is an antibiotic that can be found in Streptomyces sp. MH816-AF15. It blocks the turnover of phosphatidylinositol by inhibiting CDP-DG:inositol transferase, demonstrating both antibacterial and cytotoxic properties. Inostamycin A sodium shows potential for cancer research.</p>

<p>SPR741, a cationic peptide from polymyxin B, is being developed to treat serious Gram-negative infections.</p>

<p>Mycobactin P is one of iron(III) chelating compounds produced by most species of Mycobacteria which act as growth factors.</p>

<p>Lavendofuseomycin is a macrolide pentaene antibiotic.</p>

<p>Carnaubadiol, a triterpene from E. corollata, inhibits L. infantum and T. cruzi with IC50s: 46.2, 7.8, 14.9 μM.</p>

<p>IKD-8344: a macrocyclic dilactone with anticancer, antimicrobial, anthelmintic effects; IC50 = 0.54 ng/ml on L5178Y cells; enhances polymyxin B efficacy.</p>

<p>Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability, targeting bacterial ribosomes to impede their function</p>

<p>HIV protease-IN-1 (compound 1·succinate), a potent non-peptidic inhibitor of HIV protease, is utilized for AIDS research [1].</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>T3SS-IN-1 (compound B9) is a potent type III secretion system (T3SS) inhibitor that also suppresses hpa1 promoter activity and harpin protein expression,</p>

<p>Bruceine C is a useful organic compound for research related to life sciences and the catalog number is T125190.</p>

<p>Reveromycin D, from Streptomyces, blocks EGF in Balb/MK, halts KB/K562 growth, and shows pH-sensitive antifungal traits.</p>

<p>SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.</p>

<p>Cephabacin M4 is a new cephem antibiotic isolated from bacterial.</p>

<p>(-)-Cleistenolide, an α,β-unsaturated δ-lactone derived from Cleistochlamys kirkii Oliver, exhibits antibacterial and antitumor activity [1].</p>

<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>

<p>Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.</p>

<p>SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).</p>

<p>Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing</p>

<p>N-Hydroxypipecolic acid potassium is a metabolite of plant and a systemic acquired resistance (SAR) regulator.</p>

<p>MMV1578877 is an inhibitor of Mycobacterium ulcerans with an IC50 of 0.37 μM. It is applicable in research related to Buruli ulcer (BU).</p>

<p>Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.</p>

<p>SARS-CoV-2-IN-81 (compound 12e) is an effective AAK1 inhibitor with an IC50 value of 9.38 nM. It demonstrates antiviral activity against SARS-CoV-2 by reducing AAK1-induced phosphorylation of threonine 156 on AP2M1 and disrupting the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection.</p>

<p>Antimicrobial OV-1 peptide, derived from SMAP29, inhibits antibiotic-resistant Pseudomonas aeruginosa strains.</p>

<p>Maximin H1, an antimicrobial peptide sourced from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits efficacy against several</p>

<p>Ivermectin B1b, minor antiparasitic, binds to nematode glutamate channels, causing lasting hyperpolarization and paralysis.</p>

<p>AS-0017445 is an inhibitor targeting the main protease of the coronavirus and the virus causing Middle East Respiratory Syndrome (MERS). It functions by inhibiting viral protein processing within host cells, thereby preventing viral replication.</p>

<p>Compound A05: potent vs. Fluconazole-resistant, more effective than Miconazole, inhibits Candida albicans, MIC 0.25-1 μg/mL.</p>

<p>LL D05139(beta) is an novel antitumor antibiotic agent.</p>

<p>Amythiamicin B is a novel antimicrobial antibiotic.</p>

<p>Aszonapyrone A: a fungally-derived meroditerpene that inhibits various cancer cells (GI50=10.2-13.6 μM) and combats multidrug-resistant bacteria and malaria.</p>

<p>Pleurocidin, an antibacterial peptide, originates from the skin secretions of the Winter Flounder (Pseudopleuronectes americanus) [1].</p>

<p>2-Benzylaniline is a potential Cytochrome P450 2B6 inhibitor with an IC50 value of 4.36 μM.</p>

<p>Altromycin F is a new pluramycin-like antibiotic.</p>

<p>RFI-641 is a dendrimer-like compound with anti-RSV properties and is effective in vitro and in vivo activity.</p>

<p>Almurtide: Muramyl dipeptide derivative with anti-inflammatory, anti-tumor properties, protects mice from Pseudomonas and Candida infections.</p>

<p>Antibacterial agent 49 (example 12) is a antibacterial agent.</p>

<p>Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of</p>

<p>Quellenin, an anti-saprolegnia compound, is isolated from the deep-sea fungus Aspergillus sp. YK-76 [1].</p>

<p>IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.</p>

<p>Glutathione S-Transferase (GST) π class inhibitor is a chemical compound designed to inhibit the action of the π class of GST enzymes.</p>

<p>elomycin is a cyclic depsipeptide antibiotic with activity against Gram-positive bacteria.</p>

<p>Pyrazophos is an organic compound. It is used as a fungicide and an insecticide.</p>

<p>CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.</p>

<p>Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.</p>

<p>Retro-indolicidin, a synthetic analog of the cathelicidin-derived antimicrobial peptide-amide indolicidin, comprises a reversed 13-amino acid sequence isolated</p>

<p>CEF20, a CEF control peptide pool, is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).</p>

<p>Antibacterial agent 41 (example 3) is a antibacterial agent.</p>

<p>A-315675 is a neuramidase inhibitor with anti-infuenza activity.</p>

<p>Arylomycin A5 is a lipohexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Janthitrem F, a naphthopyran also known as 10-O-acetyljanthitrem E, is a tremorgenic mycotoxin produced by Penicillium janthinellum.</p>

<p>Monocerin, from F. larvarum, combats E. coli, B. megaterium, M. violaceum, C. fusca; kills C. erythrocephala; hinders S. halepense root growth.</p>

<p>Ansatrienin A: an antibiotic from S. collinus/rishiriensis; inhibits bone resorption &amp; kinases; enhances chemotherapy drugs.</p>

<p>Antibacterialagent 272 (Compound Z22) is a potential antibacterial agent that targets the DNA and DNA-topoisomerase II (DNA-Topo II) complex. It exhibits strong antibacterial activity, with a minimum inhibitory concentration (MIC) of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853. Antibacterialagent 272 binds by intercalating between DNA base pairs, disrupting the normal function of bacterial DNA, and is suitable for research into bacterial infectious diseases.</p>

<p>A 26771B is an antibiotic in the class of macrolide lactone.</p>

<p>Antibacterialagent 220 is a potent antibacterial compound that directly disrupts bacterial cell membranes. It is effective against both Gram-positive and Gram-negative bacteria, including resistant strains.</p>

<p>Samandarone is a major alkaloid from the European fire salamander (Salamandra salamandra terrestris).</p>

<p>Quercetin pentaacetate (Pentaacetylquercetin) has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.</p>

<p>dmDNA31: a rifamycin antibiotic, inhibits bacterial RNA polymerase, strongly kills Staphylococcus aureus.</p>

<p>(R)-Mucronulatol is a natural product that can be used as a reference standard. The CAS number of (R)-Mucronulatol is 57128-11-7.</p>

<p>Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.</p>

<p>DOTA-ubiquicidin (29-41) is a derivative of an antimicrobial peptide fragment employed for synthesizing [68Ga]Ga-DOTA-Ubiquicidin29-41, which is subsequently utilized in PET/CT imaging of infection processes. Additionally, DOTA-ubiquicidin (29-41) is applicable in the synthesis and research of radiopharmaceuticals known as radionuclide conjugates (RDC).</p>

<p>SARS-CoV-2 Mpro-IN-17 (compound S5-28) is an orally active, non-covalent inhibitor of SARS-CoV-2 Mpro, with an EC50 value of 1.35 μM. It is applicable for research related to COVID-19.</p>

<p>Antibacterialagent 181 (Compound 3f) is an effective cationic antibacterialagent (antibacterialagent) with low cytotoxicity. It exhibits a minimum inhibitory concentration (MIC) of 2 μg/mL against both Staphylococcus aureus and Escherichia coli.</p>

<p>β-Cedrene ((+)-β-Cedrene), a sesquiterpene isolated from both Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibits a broad range of biological activities, including antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal properties. Additionally, β-Cedrene acts as a potent competitive inhibitor of the CYP2B6-mediated bupropion hydroxylase activity, demonstrating a K i value of 1.6 μM [1] [2].</p>

<p>Monocaprin is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.</p>

<p>Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.</p>

<p>Anisocoumarin H is a useful organic compound for research related to life sciences. The catalog number is T126178 and the CAS number is 123237-86-5.</p>

<p>Sch 31828 is an antibiotic from Microbispora.</p>

<p>Furaltadone L-tartrate, a nitrofuran, may help study Salmonella enteritidis in chickens; it's an antibacterial agent against staphylococci.</p>

<p>1-Deoxymannojirimycin hydrochloride is a selective α1,2-mannosidase inhibitor(IC50: 20 μM).</p>

<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>

<p>Arylomycin A3 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Lankacyclinone C, a congener of lankacidin C devoid of the δ-lactone moiety, exhibits antitumor activity.</p>

<p>Arylomycin B4 is a lipidic hexapeptide antibiotic (antibiotic) targeting Gram-positive bacteria.</p>

<p>3′-Omethyl-5′-hydroxydiplacone (compound 2), a C-6-geranylflavonoid isolated from the ethanol extract of Paulownia tomentosa fruits, exhibits antibacterial</p>

<p>MMV674850: IC50 asexual parasites 2.7-4.5 nM; early gametocytes 4.5 ± 3.6 nM, late 28.7 ± 0.2 nM.</p>

<p>Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].</p>

<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Simpinicline (OC-02) (OC-02) is an nAChR agonist that activates the trigeminal parasympathetic pathway and can be used to treat dry eye.</p>

<p>17-Hydroxyneomatrine, a compound derived from Sophora flavescens, exhibits multifaceted biological activities, including the inhibition of human cervical</p>

<p>Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>

<p>Compound 6 (Antibacterial agent 161, trifluoromethanesulfonate) exhibits antibacterial properties and demonstrates significant antiproliferative effects against</p>

<p>Antibiotic LB 10517 is a catechol-substituted cephalosporin with a broad spectrum of antibacterial.</p>

<p>S2H97 is a neutralizing antibody that broadly protects against viruses such as neococcal pneumonia and SARS under clade B of coronavirus B.</p>

<p>RSM01 is a fully human IgG1 monoclonal antibody that targets a site in the pre-F region of RSV with a YTE half-life prolongation mutation.</p>

<p>Amoxicillin + potassium clavulanate (4:1) is a broad-spectrum, well-absorbed oral antibiotic blocking cell wall synthesis.</p>