Microbiology/Virology

<p>Collismycin A, from Streptomyces, has antibacterial, antiproliferative, and neuroprotective effects. It inhibits various cancer cells and is iron-complexing.</p>

<p>CAY10742: Oral oxadiazole antibiotic, combats Gram-positive bacteria &amp; MRSA, effective against resistant strains, works in mouse models. MICs = 1-4 μg/ml.</p>

<p>Retavibart is a fusion protein (glycoprotein F) of the human respiratory syncytial virus (RSV). It can be used for antiviral research.</p>

<p>Luteoreticulin, a nitro-containing bacterial metabolite first isolated from S. luteoreticuli, exhibits mosquitocidal activity against A. aegypti at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.</p>

<p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>

<p>Eflornithine blocks ornithine decarboxylase, treating African trypanosomiasis and female facial hair.</p>

<p>Herquline A, a P. herquei alkaloid, blocks influenza A-induced cell death (IC50 = 10 μg/ml) and viral replication; hinders ADP/PAF-induced platelet clumping.</p>

<p>ABBV-4083 is a Tylosin A analog that has potent anti-Wolbachia and anti-filarial activity.</p>

<p>N2-Acetylaciclovir (Aciclovir EP Impurity F) is a derivative of the antiviral compound Aciclovir, which has selective T-cell immunotoxicity.</p>

Meleagrin: Penicillium-derived alkaloid, inhibits FabI and c-Met, targets breast cancer metastasis, antimicrobial.

<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>

<p>KPC-2-IN-1, a boronic acid KPC-2 inhibitor (Ki 0.032 μM), boosts cefotaxime against KPC-2 E. coli; tolerable in HEK-293 cells.</p>

<p>"Mpro inhibitor N3 hemihydrate blocks SARS-CoV-2's main protease (Mpro), with an EC50 of 16.77 μM and targets various coronaviruses."</p>

<p>Saccharocarcin B was isolated from the fermentation broth of the actinomycete Saccharothrix aerocolongenes subsp.antibiotica SCC1886.</p>

<p>MMV674850: IC50 asexual parasites 2.7-4.5 nM; early gametocytes 4.5 ± 3.6 nM, late 28.7 ± 0.2 nM.</p>

<p>3′-Omethyl-5′-hydroxydiplacone (compound 2), a C-6-geranylflavonoid isolated from the ethanol extract of Paulownia tomentosa fruits, exhibits antibacterial</p>

<p>Posizolid(AZD-5847,AZD-2563) is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections.</p>

<p>Antibacterial agent 32 fights E. coli (NCTC 13351, M 50, 7 MP) with MICs: 1, 2, 8 mcg/mL.</p>

<p>Dermaseptin-S2, an antimicrobial peptide sourced from frog skin, exhibits activity against filamentous fungi [1].</p>

<p>Dihydrotetrodecamycin, a fungal metabolite extracted from S. nashvillensis, exhibits antibacterial properties. It demonstrates activity against the fish-pathogenic bacterium P. piscicida.</p>

<p>AB 3217-B is an anti-mite substance isolated from streptomycete strain.</p>

<p>Kuguacin N is a useful organic compound for research related to life sciences and the catalog number is T126345.</p>

<p>AA58 enhances Ceftazidime efficacy by lowering its MIC.</p>

<p>10,11-Dehydrocurvularin: antibiotic, activates heat shock response, blocks TGF-β, anti-cancer.</p>

<p>rCRAMP (rat) acetate, a cathelin-related antimicrobial peptide, exhibits antibacterial activity in rat brain peptide/protein extracts.</p>

<p>SEQ-9 is an orally active inhibitor targeting the Mycobacterium tuberculosis (Mtb) 23S bacterial ribosome, demonstrating an inhibitory concentration (IC50)</p>

<p>Halocyamine B, isolated from Halocynthia roretzi, is an antibiotic peptide.</p>

<p>Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.</p>

<p>Cardol triene, a phenol in cashew shell liquid, blocks tyrosinase (IC50 22.5 μM) &amp; kills S. mansoni at 50-200 μM; used to make bis-benzoxazines.</p>

<p>BRD5018 is an antimalarial agent.</p>

<p>Cephabacin M6 is a new cephem antibiotic isolated from bacterial.</p>

<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>TSO-13 is an inhibitor of the major cysteine protease Cruzipain found in Trypanosoma cruzi, with an IC50 of 2.2 μM. In Vero cells, TSO-13 also suppresses T. cruzi, exhibiting an IC50 of 1.9 μM.</p>

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>TAN-420C is an antibiotic isolated from Streptomyces hygroscopicus with antitumour activity.</p>

<p>Cyclobendazole is a antihelmintic agent.</p>

<p>ETX0462, a gram-negative antibiotic, effectively targets Pseudomonas aeruginosa, ESKAPE pathogens, Stenotrophomonas maltophilia, and biothreats.</p>

<p>Bacilysin possesses antibactirial activity.</p>

<p>Kapurimycin A1 is an antitumor antibiotic produced by Streptomyces.</p>

<p>Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.</p>

<p>Cloxacillin Sodium: chlorinated Oxacillin derivative, semi-synthetic, treats beta-lactamase staph infections.</p>

<p>1,4-Dihydroxynaphthalene A potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.</p>

<p>CEF6 is an HLA-B7-restricted epitope from influenza, part of CEF peptides (8-12 amino acids) from CMV, EBV, and flu.</p>

<p>Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting</p>

<p>AA45 boosts Ceftazidime's efficacy by lowering its MIC value, showcasing strong antibacterial properties.</p>

<p>KR019 is a potent hepatitis B virus (HBV) capsid assembly modulator that demonstrates significant antiviral activity in HBV cells. It binds to the hydrophobic pocket at the core protein dimer-dimer interface, redirecting capsid assembly into genome-free capsids, thereby inhibiting viral replication.</p>

<p>Desacetyl cefapirin, a cefapirin metabolite, combats E. coli, K. pneumoniae, P. mirabilis, S. aureus; MICs: 120, 24, 34, 0.42 μg/ml.</p>

<p>Aspyrone, a polyketide from Aspergillus, has antifungal, antibacterial (20 µg/mL, 100 µg/disc), and nematocidal properties (10-1000 mg/L).</p>

<p>Compound PDK0095, with CAS No. 1777-82-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0095 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>