Microbiology/Virology

N-Demethylansamitocin P-3, an ansamycin antibiotic derivative with antitumor properties, is synthesized by S. minutiscleroticus IFO 13361.

Spirovirimat (Compound 7) is a potent inhibitor of the monkeypox virus (MPXV) p37 protein, with an IC50 value of 35 nM. It obstructs the formation of extracellular viral particles by inhibiting the viral membrane envelopment process. Spirovirimat shows potential for studying monkeypox virus infections.

Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.

Cinerubin B is a glycosylated anthracycline antibiotic that exhibits anticancer activity. It is derived from Streptomyces sp. SPB74.

9-Carboxymethoxymethylguanine, Aciclovir's main metabolite, is a strong antiviral guanosine analog.

Compound 480-68-2, with CAS No. 480-68-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 480-68-2 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Salviandulin E, a diterpenoid from Salvia leucantha, has antitrypanosomal effects with an IC50 of 0.72 µg/mL against T.b. brucei.

SARS-CoV-2 Mpro-IN-43 (Compound 1) is an inhibitor of the coronavirus main protease (Mpro) with an IC50 of 72 μM. It exerts its antiviral effects by interacting non-covalently with the key residues at the Mpro active site. This compound exhibits moderate to low cytotoxicity with CC50 values of 13.24, 41.02, and 42.26 µM in HaCaT, HEK293T, and HepG2 cells, respectively. SARS-CoV-2 Mpro-IN-43 is applicable for SARS-CoV-2 research.

Maximin H4, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory activity against a

HYNIC-UBI29-41 is composed of the bifunctional chelator HYNIC and the antimicrobial peptide UBI 29-41. It retains the antimicrobial properties of UBI 29-41, showing strong affinity for both Gram-positive and Gram-negative bacteria. When labeled with the radioactive element Technetium (99mTc), HYNIC-UBI29-41 can be used as an imaging agent for detecting bacterial infections in mouse models.

3-Deoxyaphidicolin is a phytotoxin that inhibits root growth in lettuce seedlings. Additionally, 3-Deoxyaphidicolin exhibits inhibitory activity against the protozoan parasites Leishmania major and Leishmania braziliensis.

Parasin I (TFA), a peptide derived from the 19 amino acids of histone H2A and isolated from catfish skin, exhibits antimicrobial activity [1].

LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.

TP2 inhibits Pks13, halting mycolic acid production and killing mycobacteria, with a 1 μM MIC against Mycobacterium tuberculosis.

Pks13-IN-1 (Compound 44) is an orally active inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13). It inhibits the M. tuberculosis H37Rv strain with a minimum inhibitory concentration (MIC) of 0.07 μM. In mouse models, Pks13-IN-1 demonstrates antibacterial activity.

(+)-Carbovir triphosphate, Abacavir's active metabolite, studied for HIV-1 resistance and inhibition mechanisms.

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

SARS-CoV-2-IN-27: bifunctional diphosphate ester, C6 alkyl, molecular tweezers, antiviral (IC50: 1-1.7μM), disrupts membranes (EC50: 6.5μM).

Ditercalinium chloride, an anticancer agent, inhibits human DNA polymerase gamma activity and can deplete mitochondrial DNA in both mouse and human cells. Additionally, Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein [1] [2].

V–C6–Bg-PhCl TFA (compound 5e) is a biguanide-vancomycin conjugate with broad-spectrum antibacterial activity. It effectively eradicates biofilm-forming Gram-negative and Gram-positive bacteria.

Salivaricin B is a broad-spectrum bacteriocin produced by Lactobacillus M7, capable of inhibiting the growth of Listeria monocytogenes, Bacillus cereus, Brochothrix thermosphacta, Enterococcus faecalis, and various Lactobacilli.

Tetrahydrobostrycin is a secondary metabolite produced by Aspergillus sp., demonstrating mild inhibitory effects against Staphylococcus aureus and Escherichia coli, with inhibition zones measuring 15 mm and 9.2 mm respectively (100 mg/disc).

Fortimicin C is a bioactive chemical.

"Ribostamycin (Vistamycin) is a broad-spectrum antibiotic, effective against many bacteria and inhibits PDI."

Corallopyronin A is an antibiotic that can be isolated from *Corallococcus coralloides* [1].

Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].

LpxC-IN-5: potent non-hydroxamate LpxC enzyme inhibitor, IC50=20 nM, antibacterial, with MICs for E. coli, P. aeruginosa, K. pneumoniae at 16, 4, 64, 4 μg/mL.

Caprazene is a precursor molecule of semi-synthetic antibacterial antibiotics and an anti-mycobacterial compound used for tuberculosis and Mycobacterium avium complex infection research. It can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture.

Ceftizoxime, a 3rd-gen cephalosporin, targets PBPs in Gram-positive/negative bacteria, like cefotaxime, but not metabolized.

Retro-indolicidin, a synthetic analog of the cathelicidin-derived antimicrobial peptide-amide indolicidin, comprises a reversed 13-amino acid sequence isolated

Antibacterialagent 233 (Compound 7c) demonstrates inhibitory activity against Helicobacter pylori, with a minimum inhibitory concentration (MIC) ranging from 0.4 to 1.6 μg/mL. It inhibits jack bean urease with an IC50 of 0.27 μg/mL, alters the permeability of the H. pylori cell membrane, and leads to the leakage of cellular contents. Antibacterialagent 233 shows metabolic stability in both whole blood and artificial gastric fluid. Additionally, it exhibits antitumor activity against U2OS in mice.

M+B 5124 is a bioactive chemical.

Vecantoxatug is a humanized monoclonal antibody designed to target Clostridium tetani toxin (TeNT, a neurotoxin). It specifically binds to the tetanus toxin, preventing the toxin from interacting with cell receptors and thus exhibits antitoxin activity. Vecantoxatug holds potential for tetanus research.

Nannochelin B is a siderophore isolated from Nannocystis exedens.

Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.

Valclavam is a biochemical.

RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .

Althiomycin is an antibiotic.

Teicoplanin sodium: a lipoglycopeptide antibiotic with activity against HIV, SARS-CoV1/2, and MRSA.

TPS1-IN-1 (Compound O1) is a potent and broad-spectrum inhibitor of TPS1. It exhibits IC50 values of 14.73 μM for MoTPS1 (Magnaporthe oryzae TPS1) and 59.99 μM for BcTPS1 (Botrytis cinerea TPS1). TPS1-IN-1 exerts its broad-spectrum fungicidal effects by disrupting spore germination, appressorium formation, and turgor pressure accumulation in fungi. With good safety profiles, TPS1-IN-1 has potential as a candidate for novel fungicide development.

RNA binder 1 (Compound 4b) is an RNA-binding agent capable of crossing the blood-brain barrier. It selectively binds to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. This compound significantly reduces levels of the toxic polypeptides poly(GA) and poly(GP) in cells derived from amyotrophic lateral sclerosis (ALS) patients, while it has no significant impact on the antisense polypeptide poly(PR), demonstrating selectivity for sense RNA. RNA binder 1 is useful for studying ALS and frontotemporal dementia (FTD).

Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.

Nanchangmycin, a polyether antibiotic similar to dianemycin, effectively combats diverse nematodes and insects, not mammals/plants.

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.

Agent 37 from patent WO2015063714A1 is a potent antimicrobial for bacterial infection research.

PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an

Dihydroaeruginoic acid, an antibiotic sourced originally from P. fluorescens, exhibits antimicrobial efficacy in disc assays against diverse pathogens, including R. solani, P. ultimum, B. cinerea, S. rolfsii, C. gloeosporioides, F. oxysporum, and S. tritici fungi, along with B. subtilis, E. herbicola, and S. albus bacteria, at a concentration of 200 μg/disc.