Microbiology/Virology

<p>Asperglaucin B, from Aspergillus chevalieri, fights Pseudomonas syringae and Bacillus cereus with 6.25 μM MIC.</p>

<p>PNU-142721, reverse transcriptase inhibitor, is used to treat human immunodeficiency virus (HIV) infection.</p>

<p>Trypanothione synthetase-IN-2: competitive inhibitor for Leishmania TryS, IC50 5.4 μM with spermidine.</p>

<p>Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.</p>

<p>NS5A-IN-1 is a proagent of the HCV NS5A inhibitor Pibrentasvir (ABT-530).</p>

<p>Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects.</p>

<p>Dalbavancin HCl (MDL-63397 HCl), a semi-synthetic antibiotic, targets Gram-positive bacteria with low MICs for S. aureus and B. anthracis.</p>

<p>Thio-ITP (6-Thioinosine 5'-triphosphate) inhibits RNA polymerases I &amp; II with Ki of 40.9 &amp; 38.0 μM.</p>

<p>Compound 4b (antitrypanosomal agent 13) is a potent antitrypanosomal with notable trypanocidal and cytotoxic activities, exhibiting GI50 values of 0.18 μM</p>

<p>M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

<p>Cycloaspeptide A, obtained from the endophytic fungus Penicillium janczewskii, exhibits antiparasitic properties [1].</p>

<p>Gallichrome: an active peptide that interacts with siderophore hydroxamate; used in iron uptake research in gram-positive/negative bacteria.</p>

<p>Celangulatin C: insecticidal sesquiterpene from Pseudolarix kaempferi root bark, LD50 of 280.4 μg/mL against Mythimna separata.</p>

<p>Sevirumab (MSL-109), a human IgG1 antibody, blocks CMV by targeting gH complexes; EC50 of 0.3 μg/mL.</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>AA35 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Cefamandole is a broad-spectrum cephalosporin antibiotic with antibacterial activity against Bacillus subtilis and Escherichia coli.</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>Lysolipin I is a bioactive chemical.</p>

<p>Lopinavir Metabolite M-1, derived from Lopinavir, inhibits HIV protease (Ki=0.7 pM) and shows antiviral activity in vitro.</p>

<p>N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.</p>

<p>Zifanocycline: 3rd-gen aminomethylcycline antibiotic, broad-spectrum against resistant bacteria, oral/injectable, for various infections.</p>

<p>Phanerosporic acid, from P. chrysosporum, fights bacteria like B. cereus and fungi including C. cladosporioides; used in macrolide synthesis.</p>

<p>NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic</p>

<p>Neoabietic acid, from Pinus palustris resin, is acid-sensitive and has antibacterial properties.</p>

<p>(S)-Dinotefuran, a neonicotinoid, more toxic to bees than its R-isomer, targets α8 nAChR.</p>

<p>Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.</p>

<p>Paclobutrazol ((R,R)-paclobutrazol) is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.1,2It also has</p>

<p>Antibacterial agent 12 targets antibiotic-susceptible/resistant Gram-positive bacteria.</p>

<p>Dodecamethylpentasiloxane can be used as a bed bug insecticide. Dodecamethylpentasiloxane is a component of siloxane and can be used as silicone oil.</p>

<p>2,4-Diacetylphloroglucinol is a useful organic compound for research related to life sciences. The catalog number is T21619 and the CAS number is 2161-86-6.</p>

<p>4-Deoxy-4α-phorbol, a tetracyclic diterpene identified in E.</p>

<p>Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity [1] .</p>

<p>N-0920 is a potent TMPRSS2 inhibitor with an IC50 value of 0.35 nM. It effectively inhibits the entry of SARS-CoV-2 variants [EG.5.1] and [JN.1] into Calu-3 cells, exhibiting EC50 values of 300 pM and 90 pM, respectively.</p>

<p>SARS-CoV-2 nsp14-IN-4 (Compound 12q), a non-cytotoxic and cell-permeable inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50 = 19 nM), is employed in COVID-19</p>

<p>Antibacterial agent 61 (example 27) is a antibacterial agent.</p>

<p>Zegruvirimat is an antiviral agent. Zegruvirimat has antiviral activity [1] .</p>

<p>HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.</p>

<p>Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic.</p>

<p>Hypoglaunine D, an anti-HIV analogue of Triptonine B, inhibits HIV in H9 cells with an EC50 of 22 μg/ml.</p>

<p>Lomtegovimab (BI 767551) is a monoclonal antibody that targets and neutralizes SARS-CoV-2 for COVID-19 research.</p>

<p>HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, demonstrating efficacy with an EC50 value of 0.65 μM in MTS cells and 0.6 μM in CPE cells[1].</p>

<p>Cervinomycin A2 is an antibiotic effective against anaerobic bacteria, isolated from the Streptomyces genus, specifically Cervinomycetes. It exhibits strong inhibitory effects on Clostridium perfringens, Peptostreptococcus, and Bacteroides fragilis.</p>

Lactoferricin B (4-14), bovine (TFA), a 4-14 residue peptide from lactoferrin, has broad-spectrum antimicrobial properties.

<p>Hatomamicin is a biochemical.</p>

<p>MMV1634566 is an effective antimalarial agent that can inhibit Plasmodium falciparum and exhibits cytotoxicity.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Pezadeftide, a potent antifungal peptide, readily penetrates fungal cells, eliciting an immediate mitochondrial response that leads to hyperpolarization of the</p>

<p>Glicophenone, an antibacterial agent, demonstrates minimum inhibitory concentrations (MICs) of 32 μg/mL against multiple strains, including MRSA OM481, MRSA</p>