LRRK2
LRRK2 inhibitors are compounds that target and inhibit the activity of Leucine-Rich Repeat Kinase 2 (LRRK2), an enzyme involved in several cellular processes, including autophagy, vesicle trafficking, and inflammation. Mutations in the LRRK2 gene are associated with an increased risk of developing Parkinson's disease, making LRRK2 a significant target for neurodegenerative disease research. Inhibitors of LRRK2 are crucial for exploring its role in Parkinson's disease and for developing potential therapeutic strategies. At CymitQuimica, we offer a selection of LRRK2 inhibitors to support your research in neurodegeneration, kinase signaling, and therapeutic development.
Found 33 products of "LRRK2"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
BIX 02565
CAS:<p>BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).</p>Formula:C26H30N6O2Purity:97.44% - 99.7%Color and Shape:SolidMolecular weight:458.56MLi-2
CAS:<p>MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.</p>Formula:C21H25N5O2Purity:98.96%Color and Shape:SolidMolecular weight:379.46CZC-54252 hydrochloride
CAS:<p>CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.</p>Formula:C22H26Cl2N6O4SPurity:98.21%Color and Shape:SolidMolecular weight:541.45JH-XII-03-02
CAS:<p>JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PD</p>Formula:C43H51N9O10Purity:98%Color and Shape:SolidMolecular weight:853.92XL01126
<p>XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.</p>Formula:C50H64ClFN10O6S2Color and Shape:SolidMolecular weight:1019.69LRRK2 inhibitor 1
CAS:<p>LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.</p>Formula:C20H23N5O4Purity:99.94%Color and Shape:SolidMolecular weight:397.43EB-42486
CAS:<p>EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.</p>Formula:C22H22N8OPurity:99.53%Color and Shape:SolidMolecular weight:414.46Anti-LRRK2 Antibody (1C773)
<p>Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.</p>Color and Shape:Odour LiquidPF-06447475
CAS:<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Formula:C17H15N5OPurity:98.61% - 99.62%Color and Shape:SolidMolecular weight:305.33GNE0877
CAS:<p>GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).</p>Formula:C14H16F3N7Purity:98.01% - 99.97%Color and Shape:SolidMolecular weight:339.32LRRK2-IN-1
CAS:<p>LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.</p>Formula:C31H38N8O3Purity:98% - 98.82%Color and Shape:SolidMolecular weight:570.69PFE-360
CAS:<p>PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).</p>Formula:C16H16N6OPurity:98.14% - 99.73%Color and Shape:SolidMolecular weight:308.34GSK2578215A
CAS:<p>GSK2578215A is a potent and selective LRRK2 kinase inhibitor.</p>Formula:C24H18FN3O2Purity:99.57% - 99.94%Color and Shape:SolidMolecular weight:399.42GNE-7915 tosylate
CAS:<p>GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.</p>Formula:C26H29F4N5O6SColor and Shape:SolidMolecular weight:615.6PF-06454589
CAS:<p>PF-06454589 is a potent inhibitor of LRRK2.</p>Formula:C14H16N6OPurity:99.06%Color and Shape:SolidMolecular weight:284.32HG-10-102-01
CAS:<p>HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).</p>Formula:C17H20ClN5O3Purity:99.59%Color and Shape:SolidMolecular weight:377.83CZC-25146 hydrochloride
CAS:<p>CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.</p>Formula:C22H26ClFN6O4SPurity:98.76%Color and Shape:SolidMolecular weight:525JH-II-127
CAS:<p>JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).</p>Formula:C19H21ClN6O3Purity:98.32%Color and Shape:SolidMolecular weight:416.86IKK 16
CAS:<p>IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.</p>Formula:C28H29N5OSPurity:98.76% - 99.61%Color and Shape:SolidMolecular weight:483.63CZC-25146
CAS:<p>CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).</p>Formula:C22H25FN6O4SPurity:97.68%Color and Shape:SolidMolecular weight:488.54GNE-9605
CAS:<p>GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).</p>Formula:C17H20ClF4N7OPurity:98.55% - 98.75%Color and Shape:SolidMolecular weight:449.83GNE-7915
CAS:<p>GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.</p>Formula:C19H21F4N5O3Purity:98% - ≥95%Color and Shape:SolidMolecular weight:443.4CZC-54252
CAS:<p>CZC-54252 is a potent inhibitor of LRRK2.</p>Formula:C22H25ClN6O4SPurity:99.39%Color and Shape:SolidMolecular weight:504.99PF-06455943
CAS:<p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.</p>Formula:C17H14FN5OColor and Shape:SolidMolecular weight:323.32PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Formula:C17H16N6O2SColor and Shape:SolidMolecular weight:368.41LRRK2-IN-10
CAS:<p>LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2</p>Formula:C20H15N5OPurity:98%Color and Shape:SolidMolecular weight:341.37LRRK2-IN-7
CAS:<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Formula:C24H26N6OPurity:99.26%Color and Shape:SolidMolecular weight:414.5LRRK2-IN-16
CAS:<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formula:C18H19N5OSColor and Shape:SolidMolecular weight:353.441LRRK2-IN-4
CAS:<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formula:C25H29ClF2N6O2Color and Shape:SolidMolecular weight:518.99LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Formula:C24H26F2N4O2SColor and Shape:SolidMolecular weight:472.55LRRK2-IN-2
CAS:<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formula:C23H23Cl2F3N6O2Color and Shape:SolidMolecular weight:543.37LRRK2-IN-3
CAS:<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Formula:C25H29ClF2N6O2Color and Shape:SolidMolecular weight:518.99LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Formula:C23H24F2N4O2SColor and Shape:SolidMolecular weight:458.52
