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LRRK2

LRRK2

LRRK2 inhibitors are compounds that target and inhibit the activity of Leucine-Rich Repeat Kinase 2 (LRRK2), an enzyme involved in several cellular processes, including autophagy, vesicle trafficking, and inflammation. Mutations in the LRRK2 gene are associated with an increased risk of developing Parkinson's disease, making LRRK2 a significant target for neurodegenerative disease research. Inhibitors of LRRK2 are crucial for exploring its role in Parkinson's disease and for developing potential therapeutic strategies. At CymitQuimica, we offer a selection of LRRK2 inhibitors to support your research in neurodegeneration, kinase signaling, and therapeutic development.

Found 33 products of "LRRK2"

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  • GNE-9605
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    GNE-9605

    CAS:
    <p>GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).</p>
    Formula:C17H20ClF4N7O
    Purity:98.55% - 98.75%
    Color and Shape:Solid
    Molecular weight:449.83

    Ref: TM-T1770

  • GNE-7915
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    GNE-7915

    CAS:
    <p>GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.</p>
    Formula:C19H21F4N5O3
    Purity:98% - ≥95%
    Color and Shape:Solid
    Molecular weight:443.4

    Ref: TM-T1945

  • CZC-54252
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    CZC-54252

    CAS:
    <p>CZC-54252 is a potent inhibitor of LRRK2.</p>
    Formula:C22H25ClN6O4S
    Purity:99.39%
    Color and Shape:Solid
    Molecular weight:504.99

    Ref: TM-T2022

  • PF-06455943
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    PF-06455943

    CAS:
    <p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK &amp; Parkinson's research.</p>
    Formula:C17H14FN5O
    Color and Shape:Solid
    Molecular weight:323.32

    Ref: TM-T72999

  • PF-06371900
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    PF-06371900

    CAS:
    <p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>
    Formula:C17H16N6O2S
    Color and Shape:Solid
    Molecular weight:368.41

    Ref: TM-T70363

  • LRRK2-IN-10
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    LRRK2-IN-10

    CAS:
    <p>LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2</p>
    Formula:C20H15N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:341.37

    Ref: TM-T79746

  • LRRK2-IN-7
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    LRRK2-IN-7

    CAS:
    <p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, &gt;1000x selectivity vs kinases/channels/CYPs.</p>
    Formula:C24H26N6O
    Purity:99.26%
    Color and Shape:Solid
    Molecular weight:414.5

    Ref: TM-T73176

  • LRRK2-IN-16
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    LRRK2-IN-16

    CAS:
    <p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>
    Formula:C18H19N5OS
    Color and Shape:Solid
    Molecular weight:353.441

    Ref: TM-T204380

  • LRRK2-IN-4
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    LRRK2-IN-4

    CAS:
    <p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>
    Formula:C25H29ClF2N6O2
    Color and Shape:Solid
    Molecular weight:518.99

    Ref: TM-T63621

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    LRRK2-IN-5

    <p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>
    Formula:C24H26F2N4O2S
    Color and Shape:Solid
    Molecular weight:472.55

    Ref: TM-T63057

  • LRRK2-IN-2
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    LRRK2-IN-2

    CAS:
    <p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>
    Formula:C23H23Cl2F3N6O2
    Color and Shape:Solid
    Molecular weight:543.37

    Ref: TM-T63824

  • LRRK2-IN-3
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    LRRK2-IN-3

    CAS:
    <p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>
    Formula:C25H29ClF2N6O2
    Color and Shape:Solid
    Molecular weight:518.99

    Ref: TM-T63620

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    LRRK2-IN-6

    <p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>
    Formula:C23H24F2N4O2S
    Color and Shape:Solid
    Molecular weight:458.52

    Ref: TM-T62871