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LRRK2

LRRK2

LRRK2 inhibitors are compounds that target and inhibit the activity of Leucine-Rich Repeat Kinase 2 (LRRK2), an enzyme involved in several cellular processes, including autophagy, vesicle trafficking, and inflammation. Mutations in the LRRK2 gene are associated with an increased risk of developing Parkinson's disease, making LRRK2 a significant target for neurodegenerative disease research. Inhibitors of LRRK2 are crucial for exploring its role in Parkinson's disease and for developing potential therapeutic strategies. At CymitQuimica, we offer a selection of LRRK2 inhibitors to support your research in neurodegeneration, kinase signaling, and therapeutic development.

Found 45 products for "LRRK2".

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  • LRRK2-IN-2
    Targetmol
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    LRRK2-IN-2

    CAS:
    LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.
    Formula:C23H23Cl2F3N6O2
    Color and Shape:Solid
    Molecular weight:543.37

    Ref: TM-T63824

    25mg
    1,927.00€
    50mg
    2,507.00€
    100mg
    3,168.00€
  • CymitQuimica logo
    Targetmol
    + Info

    LRRK2-IN-5

    LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.
    Formula:C24H26F2N4O2S
    Color and Shape:Solid
    Molecular weight:472.55

    Ref: TM-T63057

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • LRRK2-IN-16
    Targetmol
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    LRRK2-IN-16

    CAS:
    LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.
    Formula:C18H19N5OS
    Color and Shape:Solid
    Molecular weight:353.441

    Ref: TM-T204380

    10mg
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    50mg
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  • LRRK2-IN-14
    Targetmol
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    LRRK2-IN-14

    CAS:
    LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2(G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].
    Formula:C17H18F3N5O2
    Color and Shape:Solid
    Molecular weight:381.35

    Ref: TM-T86825

    10mg
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    50mg
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  • (R,R)-LRRK2-IN-7
    Targetmol
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    (R,R)-LRRK2-IN-7

    CAS:
    (R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.
    Formula:C24H26N6O
    Color and Shape:Solid
    Molecular weight:414.50

    Ref: TM-TYD-02662

    10mg
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    50mg
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