GlyT
Glycine Transporter (GlyT) inhibitors are compounds that block the reuptake of glycine, an important inhibitory neurotransmitter in the spinal cord and brainstem. By inhibiting glycine transporters, these compounds increase the availability of glycine in the synaptic cleft, enhancing its inhibitory effects on neuronal activity. GlyT inhibitors are of interest for their potential therapeutic applications in conditions like chronic pain, spasticity, and schizophrenia. At CymitQuimica, we provide GlyT inhibitors to support your research in pain management, motor control, and neuropsychiatric disorders.
Found 24 products of "GlyT"
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LY2365109 hydrochloride
CAS:<p>LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.</p>Formula:C22H28ClNO5Purity:98.27%Color and Shape:SolidMolecular weight:421.91DCCCyb
CAS:<p>DCCCyb: oral GlyT1 inhibitor with high in vivo occupancy in rhesus monkeys, confirmed by PET tracer displacement.</p>Formula:C22H29Cl2NO3SPurity:98%Color and Shape:SolidMolecular weight:458.448-hydroxy Amoxapine
CAS:<p>8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2</p>Formula:C17H16ClN3O2Color and Shape:SolidMolecular weight:329.78SSR504734 HCl
CAS:<p>SSR504734 inhibits GlyT1 in humans, rats, mice (IC50=18, 15, 38 nM); treats schizophrenia, anxiety, depression orally.</p>Formula:C20H21Cl2F3N2OPurity:98.05% - 99.93%Color and Shape:SolidMolecular weight:433.30Sarcosine
CAS:<p>Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.</p>Formula:C3H7NO2Purity:99.90%Color and Shape:Deliquescent Water Soluble Physical Description Deliquescent Crystals Or Powder Has A Sweetish Taste (Ntp 1992)Molecular weight:89.09SSR504734
CAS:<p>SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.</p>Formula:C20H20ClF3N2OColor and Shape:SolidMolecular weight:396.83Bitopertin
CAS:<p>Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM</p>Formula:C21H20F7N3O4SPurity:98.57% - 98.71%Color and Shape:SolidMolecular weight:543.46Org 25543 hydrochloride
CAS:<p>Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2).</p>Formula:C24H33ClN2O4Purity:99.26%Color and Shape:SolidMolecular weight:448.983Opiranserin hydrochloride
CAS:<p>Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM</p>Formula:C21H35ClN2O5Purity:99.33%Color and Shape:SolidMolecular weight:430.97Opiranserin
CAS:<p>Opiranserin is a development as an injectable agent for the treatment of postoperative pain.</p>Formula:C21H34N2O5Purity:98%Color and Shape:SolidMolecular weight:394.51ASP2535
CAS:<p>ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive</p>Formula:C22H18N6OPurity:98%Color and Shape:SolidMolecular weight:382.42Org-25935
CAS:<p>Org-25935, a GlyT-1 inhibitor, is used potentially for the treatment of schizophrenia and alcohol dependence.</p>Formula:C21H26ClNO3Color and Shape:SolidMolecular weight:375.89Tilapertin
CAS:<p>Tilapertin is an oral glycine transporter type-1 inhibitor.</p>Formula:C20H21F3N2O2Purity:98%Color and Shape:SolidMolecular weight:378.39Org 24598
CAS:<p>Potent GlyT1b inhibitor, IC50 = 6.9 nM; little effect on GlyT-2, adrenoceptors, dopamine, 5HT receptors, GABA transporters.</p>Formula:C19H20F3NO3Color and Shape:SolidMolecular weight:367.36NFPS
CAS:<p>NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.</p>Formula:C24H24FNO3Purity:98%Color and Shape:SolidMolecular weight:393.45MPDC
CAS:<p>MPDC acts as a competitive inhibitor against the Na+-dependent high-affinity glutamate transporter within forebrain synaptosomes.</p>Formula:C7H9NO4Purity:98%Color and Shape:SolidMolecular weight:171.15LY 2365109 hydrochloride
CAS:<p>glycine transporter 1 (GlyT1) inhibitor</p>Formula:C22H27NO5Purity:98%Color and Shape:SolidMolecular weight:385.45PF-03463275 2HCl
CAS:<p>PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, a GlyT1 glycine transporter.</p>Formula:C19H24Cl3FN4OPurity:98%Color and Shape:SolidMolecular weight:449.78Bitopertin (R enantiomer)
CAS:<p>Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin.</p>Formula:C21H20F7N3O4SPurity:98%Color and Shape:SolidMolecular weight:543.46GSK931145
CAS:<p>GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.</p>Formula:C23H30N2OPurity:98%Color and Shape:SolidMolecular weight:350.5GlyT1 Inhibitor 1
CAS:<p>GlyT1 Inhibitor 1 is a selective and potent GlyT1 inhibitor, inhibiting rGlyT1, used in research on neurological disorders.</p>Formula:C22H21N5O2Color and Shape:SolidMolecular weight:387.43PF-03463275
CAS:<p>PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS</p>Formula:C19H22ClFN4OPurity:99.86%Color and Shape:SolidMolecular weight:376.86ALX-1393
CAS:<p>ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the</p>Formula:C23H22FNO4Purity:99.83%Color and Shape:SolidMolecular weight:395.42Iclepertin
CAS:<p>Iclepertin (BI-425809) is a GlyT1 inhibitor.Iclepertin is used for the treatment of Alzheimer;s disease and other CNS disorders.</p>Formula:C20H18F6N2O5SPurity:98.89% - 98.93%Color and Shape:SolidMolecular weight:512.42
