
Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 561 products of "Cyclooxygenase (COX) Inhibitors"
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Soquelitinib
CAS:<p>Soquelitinib (CPI-818) is a selective ITK inhibitor, inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formula:C25H30N4O4S2Purity:99.54%Color and Shape:SolidMolecular weight:514.66NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formula:C25H24O7Color and Shape:SolidMolecular weight:436.454COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Color and Shape:SolidMolecular weight:494.56COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formula:C15H10ClIN2OColor and Shape:SolidMolecular weight:396.61COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formula:C17H19NO3Color and Shape:SolidMolecular weight:285.34COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formula:C15H15NO3Color and Shape:SolidMolecular weight:257.28Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formula:C17H13BrN4O3S2Color and Shape:SolidMolecular weight:465.34COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formula:C20H27NO6SPurity:99.29% - 99.69%Color and Shape:SoildMolecular weight:409.5Racemic Naproxen
CAS:<p>Racemic Naproxen is a biochemical substance.</p>Formula:C14H14O3Purity:98%Color and Shape:Crystals From Acetone-Hexane White SolidMolecular weight:230.26Alminoprofen
CAS:<p>Alminoprofen: NSAID; reduces anaphylactic bronchoconstriction at 30 mg/kg intraduodenally.</p>Formula:C13H17NO2Color and Shape:SolidMolecular weight:219.28

