CaMK
Calcium/Calmodulin-Dependent Protein Kinase (CaMK) inhibitors are compounds that block the activity of CaMK, a kinase involved in regulating various cellular processes, including synaptic plasticity, memory formation, and gene expression in the nervous system. CaMK plays a critical role in translating calcium signals into cellular responses, and its dysregulation is associated with neurological disorders. Inhibitors of CaMK are valuable tools for studying synaptic signaling, learning, and memory. At CymitQuimica, we offer CaMK inhibitors to support your research in synaptic plasticity, cognitive function, and neuropharmacology.
Found 68 products of "CaMK"
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CBP501
CAS:<p>CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.</p>Formula:C86H122F5N29O17Color and Shape:SolidMolecular weight:1929.06Ph-HTBA
CAS:<p>Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.</p>Formula:C19H18O3Color and Shape:SolidMolecular weight:294.34A-7 hydrochloride
CAS:<p>A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.</p>Formula:C20H30Cl2N2O2SPurity:99.38%Color and Shape:SolidMolecular weight:433.44RU 45144
CAS:<p>RU 45144 is an estradiol derivative with antiestrogenic activity.</p>Formula:C28H37NO3Purity:98%Color and Shape:SolidMolecular weight:435.6HOCPCA
CAS:<p>HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.</p>Formula:C6H8O3Purity:98%Color and Shape:SolidMolecular weight:128.13W-13 hydrochloride
CAS:<p>W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.</p>Formula:C14H18Cl2N2O2SPurity:98.51%Color and Shape:White PowderMolecular weight:349.28Prenylamine lactate
CAS:<p>Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.</p>Formula:C27H33NO3Purity:98%Color and Shape:SolidMolecular weight:419.56Zaldaride maleate
CAS:<p>Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.</p>Formula:C30H32N4O6Purity:98%Color and Shape:SolidMolecular weight:544.6TX-1123
CAS:<p>TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.</p>Formula:C20H24O3Color and Shape:SolidMolecular weight:312.4CV-159
CAS:<p>CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.</p>Formula:C31H34N4O7Purity:98%Color and Shape:SolidMolecular weight:574.62W-9 hydrochloride
CAS:<p>W-9 hydrochloride is a calmodulin antagonist.</p>Formula:C16H22Cl2N2O2SPurity:98.9%Color and Shape:SolidMolecular weight:377.33Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Formula:C31H23Cl7N2OPurity:98.53%Color and Shape:SolidMolecular weight:687.7FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Formula:C18H20N4O4SColor and Shape:SolidMolecular weight:388.44BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Formula:C29H32N2O5Purity:99.57%Color and Shape:SolidMolecular weight:488.57CaMKK2-IN-1
CAS:<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Formula:C22H22N2O3Molecular weight:362.42PTCA
CAS:<p>PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.</p>Formula:C10H5Cl2NO2SColor and Shape:SolidMolecular weight:274.123CaMKIIα-IN-1
<p>CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.</p>Formula:C14H11ClO4Color and Shape:SolidMolecular weight:278.69Calmodulin antagonist-1
CAS:<p>Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.</p>Formula:C14H18Cl2N2O2SColor and Shape:SolidMolecular weight:349.27
