GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 265 products of "GluR"
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E4CPG
CAS:E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.Formula:C11H13NO4Purity:99.96%Color and Shape:SolidMolecular weight:223.23(S)-ATPO
CAS:(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Formula:C11H19N2O7PPurity:98.37% - 99.41%Color and Shape:SolidMolecular weight:322.25(RS)-3-Hydroxyphenylglycine
CAS:(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.Formula:C8H9NO3Purity:99.29%Color and Shape:SolidMolecular weight:167.16VU-29
CAS:VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.Formula:C22H16N4O3Purity:99.63%Color and Shape:SolidMolecular weight:384.39Ref: TM-T23515
2mg33.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg86.00€25mg161.00€50mg259.00€100mg371.00€200mg530.00€Chelidamic acid
CAS:Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.Formula:C7H5NO5Purity:98.11%Color and Shape:Pale Yellow PowderMolecular weight:183.12PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Formula:C17H14N2O3Purity:>99.99%Color and Shape:SolidMolecular weight:294.3DNQX
CAS:DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
Formula:C8H4N4O6Purity:97.27% - 99.1%Color and Shape:Off-White Powder With A Yellow TingeMolecular weight:252.14JNJ16259685
CAS:JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19Formula:C20H23NO3Purity:98.31%Color and Shape:SolidMolecular weight:325.4Ref: TM-T5512
1mg46.00€2mg62.00€5mg95.00€1mL*10mM (DMSO)95.00€10mg133.00€25mg278.00€50mg424.00€100mg620.00€VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Formula:C13H11ClN2O2Purity:99.60% - 99.85%Color and Shape:SolidMolecular weight:262.69FTIDC
CAS:FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.Formula:C18H23FN6OPurity:94.58%Color and Shape:SolidMolecular weight:358.41Ref: TM-T3483
1mg100.00€2mg145.00€5mg215.00€1mL*10mM (DMSO)236.00€10mg340.00€25mg565.00€50mg797.00€100mg1,071.00€CFMTI
CAS:CFMTI: potent mGluR1 allosteric antagonist, 2000x selectivity over mGluR5, IC50: 2.6 nM.Formula:C19H16FN5OPurity:97.23%Color and Shape:SolidMolecular weight:349.36Ref: TM-T3482
1mg57.00€2mg82.00€5mg120.00€1mL*10mM (DMSO)133.00€10mg170.00€25mg304.00€50mg432.00€100mg602.00€Farampator
CAS:Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.Formula:C12H13N3O2Purity:99.84% - >99.99%Color and Shape:SolidMolecular weight:231.25CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Formula:C13H13NO4Purity:97.37%Color and Shape:SolidMolecular weight:247.25Ref: TM-T19698
5mg52.00€1mL*10mM (DMSO)55.00€10mg78.00€25mg119.00€50mg172.00€100mg259.00€200mg388.00€ADX-47273
CAS:ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).Formula:C20H17F2N3O2Purity:97% - 99.22%Color and Shape:SolidMolecular weight:369.36ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Formula:C12H12N6SPurity:99.55%Color and Shape:SolidMolecular weight:272.33AZD-8529
CAS:AZD-8529: selective, oral mGluR2 modulator, EC50 285 nM; inactive on mGluR1,3-8 at 20-25 M.Formula:C24H24F3N5O3Color and Shape:SolidMolecular weight:487.47XAP044
CAS:XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.Formula:C15H9IO4Purity:97.41%Color and Shape:SolidMolecular weight:380.13Ref: TM-T21995
1mg58.00€2mg82.00€5mg107.00€1mL*10mM (DMSO)146.00€10mg197.00€25mg350.00€50mg528.00€100mg755.00€NBQX
CAS:NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.Formula:C12H8N4O6SPurity:97.66% - 99.93%Color and Shape:SolidMolecular weight:336.28Ref: TM-T4113
1mg38.00€2mg50.00€5mg84.00€1mL*10mM (DMSO)92.00€10mg114.00€25mg222.00€50mg334.00€100mg497.00€200mg717.00€pep2-EVKI acetate(1315378-67-6 free base)
Pep2-EVKI acetate, a cell-permeable peptide, disrupts PICK1-GluR2 AMPA receptor binding.Formula:C64H99N13O21Purity:97.63%Color and Shape:SolidMolecular weight:1386.55(RS)-MCPG
CAS:(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.Formula:C10H11NO4Purity:99.96%Color and Shape:SolidMolecular weight:209.2Ro 67-7476
CAS:Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.Formula:C17H18FNO2SPurity:99.69%Color and Shape:SolidMolecular weight:319.39Ref: TM-T3478
1mg34.00€2mg48.00€1mL*10mM (DMSO)78.00€5mg88.00€10mg124.00€25mg244.00€50mg442.00€100mg643.00€MPEP hydrochloride
CAS:MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).Formula:C14H12ClNPurity:99.87% - >99.99%Color and Shape:SolidMolecular weight:229.7(S)-3-Hydroxyphenylglycine
CAS:(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).Formula:C8H9NO3Purity:99.65%Color and Shape:SolidMolecular weight:167.16TAT-GluA2 3Y acetate(1404188-93-7 free base)
TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis.Systemic administration of Tat-GluA2(3Y) during the induction phase of d-amphetamine blockedFormula:C115H185N43O29Purity:99.43%Color and Shape:SolidMolecular weight:2634.02CTEP
CAS:CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-foldFormula:C19H13ClF3N3OPurity:99.17%Color and Shape:SolidMolecular weight:391.77Ref: TM-T6457
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg88.00€25mg138.00€50mg244.00€100mg330.00€200mg470.00€MTEP hydrochloride
CAS:MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)Formula:C11H9ClN2SPurity:99.58%Color and Shape:SolidMolecular weight:236.721-BCP
CAS:1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.Formula:C13H15NO3Purity:99.60%Color and Shape:SolidMolecular weight:233.26SIB-1757
CAS:SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)Formula:C12H11N3OPurity:97.37%Color and Shape:SolidMolecular weight:213.24Lu AF21934
CAS:Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).Formula:C14H16Cl2N2O2Purity:99.79%Color and Shape:SolidMolecular weight:315.2trans-ACPD
CAS:trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.Formula:C7H11NO4Purity:99.53%Color and Shape:SolidMolecular weight:173.17Ref: TM-T3484
1mg46.00€2mg59.00€1mL*10mM (DMSO)71.00€5mg94.00€10mg140.00€25mg264.00€50mg477.00€100mg692.00€IDRA-21
CAS:IDRA-21 is a positive AMPA receptor modulator.Formula:C8H9ClN2O2SPurity:99.73%Color and Shape:SolidMolecular weight:232.69LY-404187
CAS:LY404187 is a positive allosteric modulator of AMPA receptorsFormula:C19H22N2O2SPurity:99.34%Color and Shape:SolidMolecular weight:342.46Ref: TM-T7706
2mg35.00€5mg52.00€1mL*10mM (DMSO)58.00€10mg90.00€25mg164.00€50mg239.00€100mg339.00€200mg472.00€HBT1
CAS:HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neuronsFormula:C16H17F3N4O2SPurity:99.52%Color and Shape:SolidMolecular weight:386.39VU-1545
CAS:VU-1545 is mGlu5 positive allosteric modulator.Formula:C22H15FN4O3Purity:98.8%Color and Shape:SolidMolecular weight:402.38VU 0357121
CAS:VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.Formula:C17H17F2NO2Purity:99% - >99.99%Color and Shape:SolidMolecular weight:305.32Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Formula:C18H11F3N2O3Purity:97.57%Color and Shape:SolidMolecular weight:360.29VU0364770
CAS:VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGluFormula:C12H9ClN2OPurity:99.65% - >99.99%Color and Shape:SolidMolecular weight:232.67YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Formula:C11H8ClN5O4Purity:98.23%Color and Shape:SolidMolecular weight:309.66Ref: TM-T8435
1mg73.00€5mg160.00€1mL*10mM (DMSO)170.00€10mg245.00€25mg404.00€50mg567.00€100mg767.00€200mg1,018.00€Ref: TM-T8862
1mg34.00€5mg75.00€1mL*10mM (DMSO)87.00€10mg110.00€25mg245.00€50mg363.00€100mg515.00€200mg702.00€FITM
CAS:FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).Formula:C18H18FN5OSPurity:97.25% - 99.23%Color and Shape:SolidMolecular weight:371.43Ref: TM-T7292
1mg34.00€2mg44.00€1mL*10mM (DMSO)62.00€5mg66.00€10mg92.00€25mg177.00€50mg268.00€100mg394.00€MPEP
CAS:MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.Formula:C14H11NPurity:99.54%Color and Shape:SolidMolecular weight:193.24pep2-SVKI acetate
Pep2-SVKI acetate(pep2-SVKI acetate (328944-75-8 free base)) is a synthetic peptide salt that prevents internalization of AMPA-type glutamate receptor.Formula:C62H97N13O20Purity:97.14%Color and Shape:SolidMolecular weight:1344.51TCN238
CAS:TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).Formula:C12H11N3Purity:99.9% - 99.92%Color and Shape:SolidMolecular weight:197.24CNQX
CAS:CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)Formula:C9H4N4O4Purity:99.70%Color and Shape:Pale Yellow SolidMolecular weight:232.15AMN082 free base
CAS:AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.Formula:C28H28N2Purity:97.75% - 97.79%Color and Shape:SolidMolecular weight:392.54Ref: TM-T21935L
5mg48.00€1mL*10mM (DMSO)50.00€10mg71.00€25mg128.00€50mg200.00€100mg323.00€200mg450.00€MTEP
CAS:MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.Formula:C11H8N2SColor and Shape:SolidMolecular weight:200.26CX516
CAS:CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.Formula:C14H15N3OPurity:99.04% - ≥95%Color and Shape:Tan SolidMolecular weight:241.293-MATIDA
CAS:3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).Formula:C8H9NO4SPurity:99.75% - 99.96%Color and Shape:SolidMolecular weight:215.23Ref: TM-T3486
2mg34.00€5mg49.00€1mL*10mM (DMSO)49.00€10mg79.00€25mg145.00€50mg227.00€100mg339.00€200mg482.00€VU0155094
CAS:VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.Formula:C24H24N2O4SPurity:97.21%Color and Shape:SolidMolecular weight:436.52Ref: TM-T9011
1mg62.00€5mg110.00€1mL*10mM (DMSO)127.00€10mg161.00€25mg269.00€50mg371.00€100mg537.00€200mg710.00€Caroverine hydrochloride
CAS:Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.Formula:C22H28ClN3O2Purity:98.37% - 98.75%Color and Shape:SolidMolecular weight:401.9
