GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 255 products of "GluR"
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Chelidamic acid
CAS:<p>Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.</p>Formula:C7H5NO5Purity:98.11%Color and Shape:Pale Yellow PowderMolecular weight:183.12VU-1545
CAS:<p>VU-1545 is mGlu5 positive allosteric modulator.</p>Formula:C22H15FN4O3Purity:98.8%Color and Shape:SolidMolecular weight:402.38(RS)-3-Hydroxyphenylglycine
CAS:<p>(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.</p>Formula:C8H9NO3Purity:99.29%Color and Shape:SolidMolecular weight:167.16FTIDC
CAS:<p>FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.</p>Formula:C18H23FN6OPurity:94.58%Color and Shape:SolidMolecular weight:358.41E4CPG
CAS:<p>E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.</p>Formula:C11H13NO4Purity:99.96%Color and Shape:SolidMolecular weight:223.23DNQX
CAS:<p>DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)</p>Formula:C8H4N4O6Purity:97.27% - 99.1%Color and Shape:Off-White Powder With A Yellow TingeMolecular weight:252.14VU-29
CAS:<p>VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.</p>Formula:C22H16N4O3Purity:99.63%Color and Shape:SolidMolecular weight:384.39VU0361737
CAS:<p>VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.</p>Formula:C13H11ClN2O2Purity:99.60% - 99.85%Color and Shape:SolidMolecular weight:262.69(S)-ATPO
CAS:<p>(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.</p>Formula:C11H19N2O7PPurity:98.37% - 99.41%Color and Shape:SolidMolecular weight:322.25CX614
CAS:<p>CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.</p>Formula:C13H13NO4Purity:97.37%Color and Shape:SolidMolecular weight:247.25ADX-47273
CAS:<p>ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).</p>Formula:C20H17F2N3O2Purity:97% - 99.18%Color and Shape:SolidMolecular weight:369.36Farampator
CAS:<p>Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.</p>Formula:C12H13N3O2Purity:99.84% - >99.99%Color and Shape:SolidMolecular weight:231.25AZD-8529
CAS:<p>AZD-8529: selective, oral mGluR2 modulator, EC50 285 nM; inactive on mGluR1,3-8 at 20-25 M.</p>Formula:C24H24F3N5O3Color and Shape:SolidMolecular weight:487.47NBQX
CAS:<p>NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.</p>Formula:C12H8N4O6SPurity:97.66% - 99.42%Color and Shape:SolidMolecular weight:336.28XAP044
CAS:<p>XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.</p>Formula:C15H9IO4Purity:97.41%Color and Shape:SolidMolecular weight:380.13ADX88178
CAS:<p>ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.</p>Formula:C12H12N6SPurity:99.55%Color and Shape:SolidMolecular weight:272.33SIB-1757
CAS:<p>SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)</p>Formula:C12H11N3OPurity:97.37%Color and Shape:SolidMolecular weight:213.24MPEP
CAS:<p>MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.</p>Formula:C14H11NPurity:99.54%Color and Shape:SolidMolecular weight:193.24(RS)-MCPG
CAS:<p>(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.</p>Formula:C10H11NO4Purity:99.96%Color and Shape:SolidMolecular weight:209.2TCN238
CAS:<p>TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).</p>Formula:C12H11N3Purity:99.9% - 99.92%Color and Shape:SolidMolecular weight:197.24VU0364770
CAS:<p>VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu</p>Formula:C12H9ClN2OPurity:99.65% - >99.99%Color and Shape:SolidMolecular weight:232.67CNQX
CAS:<p>CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)</p>Formula:C9H4N4O4Purity:99.70%Color and Shape:Pale Yellow SolidMolecular weight:232.15PHCCC
CAS:<p>PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.</p>Formula:C17H14N2O3Purity:>99.99%Color and Shape:SolidMolecular weight:294.31-BCP
CAS:<p>1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.</p>Formula:C13H15NO3Purity:99.60%Color and Shape:SolidMolecular weight:233.26(S)-3-Hydroxyphenylglycine
CAS:<p>(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).</p>Formula:C8H9NO3Purity:99.65%Color and Shape:SolidMolecular weight:167.16JNJ16259685
CAS:<p>JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19</p>Formula:C20H23NO3Purity:98.31%Color and Shape:SolidMolecular weight:325.4Lu AF21934
CAS:<p>Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).</p>Formula:C14H16Cl2N2O2Purity:99.79%Color and Shape:SolidMolecular weight:315.2LY-404187
CAS:<p>LY404187 is a positive allosteric modulator of AMPA receptors</p>Formula:C19H22N2O2SPurity:99.34%Color and Shape:SolidMolecular weight:342.46IDRA-21
CAS:<p>IDRA-21 is a positive AMPA receptor modulator.</p>Formula:C8H9ClN2O2SPurity:99.73%Color and Shape:SolidMolecular weight:232.69trans-ACPD
CAS:<p>trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.</p>Formula:C7H11NO4Purity:99.53%Color and Shape:SolidMolecular weight:173.17Ro0711401
CAS:<p>Ro0711401 is an agonist of mGlu1 receptor.</p>Formula:C18H11F3N2O3Purity:97.57%Color and Shape:SolidMolecular weight:360.29YM90K
CAS:<p>YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.</p>Formula:C11H8ClN5O4Purity:98.23%Color and Shape:SolidMolecular weight:309.66HBT1
CAS:<p>HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons</p>Formula:C16H17F3N4O2SPurity:99.52%Color and Shape:SolidMolecular weight:386.393-MATIDA
CAS:<p>3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).</p>Formula:C8H9NO4SPurity:99.75% - 99.96%Color and Shape:SolidMolecular weight:215.23VU 0357121
CAS:<p>VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.</p>Formula:C17H17F2NO2Purity:99% - >99.99%Color and Shape:SolidMolecular weight:305.32MTEP hydrochloride
CAS:<p>MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)</p>Formula:C11H9ClN2SPurity:99.58%Color and Shape:SolidMolecular weight:236.72FITM
CAS:<p>FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).</p>Formula:C18H18FN5OSPurity:97.25%Color and Shape:SolidMolecular weight:371.43ML 254
CAS:<p>是一种化学合成中的砌块</p>Formula:C18H15FN2O2Purity:98.09%Color and Shape:SolidMolecular weight:310.32AMN082 free base
CAS:<p>AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.</p>Formula:C28H28N2Purity:97.75% - 97.79%Color and Shape:SolidMolecular weight:392.54MPEP hydrochloride
CAS:<p>MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).</p>Formula:C14H12ClNPurity:99.87% - >99.99%Color and Shape:SolidMolecular weight:229.7CX516
CAS:<p>CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.</p>Formula:C14H15N3OPurity:99.04% - ≥95%Color and Shape:Tan SolidMolecular weight:241.29MTEP
CAS:<p>MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.</p>Formula:C11H8N2SColor and Shape:SolidMolecular weight:200.26Ro 67-7476
CAS:<p>Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.</p>Formula:C17H18FNO2SPurity:99.69%Color and Shape:SolidMolecular weight:319.39CTEP
CAS:<p>CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold</p>Formula:C19H13ClF3N3OPurity:99.17%Color and Shape:SolidMolecular weight:391.77VU0155094
CAS:<p>VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.</p>Formula:C24H24N2O4SPurity:97.21%Color and Shape:SolidMolecular weight:436.52Caroverine hydrochloride
CAS:<p>Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.</p>Formula:C22H28ClN3O2Purity:98.37% - 98.75%Color and Shape:SolidMolecular weight:401.9VU 0364439
CAS:<p>VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).</p>Formula:C18H13Cl2N3O3SPurity:97.9%Color and Shape:SolidMolecular weight:422.29JNJ-42153605
CAS:<p>JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).</p>Formula:C22H23F3N4Purity:97.25% - 98.57%Color and Shape:SolidMolecular weight:400.44VU0155041
CAS:<p>VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).</p>Formula:C14H15Cl2NO3Purity:99.52% - 99.56%Color and Shape:SolidMolecular weight:316.18JNJ-40411813
CAS:<p>JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).</p>Formula:C20H25ClN2OPurity:99.74%Color and Shape:SolidMolecular weight:344.88
