AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Found 574 products of "AChR"
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TC-T 6000
CAS:<p>TC-T 6000 (hENT4-IN-1) is an ENT4 inhibitor with vasodilator activity that inhibits hENT1 and hENT2 for the study of cancer and cardiovascular damage.</p>Formula:C26H48N8O2Purity:98.14%Color and Shape:SolidMolecular weight:504.71Tarafenacin D-tartrate
CAS:<p>Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over the M2 receptor.</p>Formula:C25H26F4N2O8Purity:99.86%Color and Shape:SolidMolecular weight:558.48SIB-1553A hydrochloride
CAS:<p>SIB-1553A hydrochloride is a nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand</p>Formula:C13H20ClNOSPurity:99.56% - 99.73%Color and Shape:SolidMolecular weight:273.82JNJ-39393406
CAS:<p>JNJ-39393406 is an α7 nicotinic acetylcholine receptor positive allosteric modulator for the study of tobacco dependence and Alzheimer's disease.</p>Formula:C19H18F2N6O3Purity:98.5%Color and Shape:SolidMolecular weight:416.38PHA 543613
CAS:<p>PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.</p>Formula:C15H17N3O2Purity:99.43% - 99.96%Color and Shape:SolidMolecular weight:271.31Thonzylamine hydrochloride
CAS:<p>Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic.</p>Formula:C16H23ClN4OPurity:99.67%Color and Shape:White Crystalline PowderMolecular weight:322.83Desformylflustrabromine hydrochloride
CAS:<p>Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.</p>Formula:C17H12INO5Purity:98.12%Color and Shape:SolidMolecular weight:437.19AQW051
CAS:<p>AQW051 (VQW-765) is an oral α7-nAChR activator for cognitive impairments, used in anxiety disorder studies.</p>Formula:C19H22N2OPurity:99.94%Color and Shape:SolidMolecular weight:294.39PF-03635659
CAS:<p>PF-03635659: potent M3 antagonist, Ki=0.2 nM, long half-life, potential COPD treatment.</p>Formula:C28H32N2O3Purity:98.39% - 99.83%Color and Shape:SolidMolecular weight:444.57rel-(1R,2R)-Vesamicol Hydrochloride
CAS:<p>Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a acetylcholine transport inhibitor.</p>Formula:C17H26ClNOPurity:99.88%Color and Shape:SolidMolecular weight:295.85SCH-900271
CAS:<p>SCH-900271 treats dyslipidemia by targeting nicotinic acid receptors, addressing hyperlipidaemia.</p>Formula:C14H16N2O4Purity:98.82% - 99.93%Color and Shape:SolidMolecular weight:276.29CP-810123
CAS:<p>CP-810123 is an α7 nAChR agonist used to treat cognitive deficits associated with psychiatric or neurological disorders such as schizophrenia.</p>Formula:C14H18N4OPurity:98.63% - 99.60%Color and Shape:SolidMolecular weight:258.32McN-A 343
CAS:<p>McN-A 343: Selective M1 muscarinic agonist; reduces inflammation in colitis models.</p>Formula:C14H18Cl2N2O2Purity:99.65%Color and Shape:SolidMolecular weight:317.21Tribendimidine
CAS:<p>Tribendimidine: broad-spectrum oral anthelmintic, nAChR agonist, effective against A. lumbricoides and N. americanus.</p>Formula:C28H32N6Purity:≥98%Color and Shape:SolidMolecular weight:452.59Xanomeline
CAS:<p>Xanomeline: orally active, M1/M4 selective activator for neurological disorders; promising in trials, crosses blood-brain barrier, liver metabolized.</p>Formula:C14H23N3OSPurity:99.61%Color and Shape:SolidMolecular weight:281.42Dimethindene
CAS:<p>Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.</p>Formula:C20H24N2Purity:98.3% - 98.99%Color and Shape:SolidMolecular weight:292.42ASM-024
CAS:<p>ASM-024, a synthetic piperazine, activates nicotinic and β2-adrenergic receptors for potential asthma and bronchitis treatment with anti-inflammatory effects.</p>Formula:C15H25N2Purity:99.74%Color and Shape:SolidMolecular weight:233.37Otenzepad
CAS:<p>Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.</p>Formula:C24H31N5O2Purity:99.79%Color and Shape:SolidMolecular weight:421.54NB001
CAS:<p>NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.</p>Formula:C12H20N6OPurity:99.69%Color and Shape:Off-White To Pale Pink SolidMolecular weight:264.33Xanomeline oxalate
CAS:<p>Xanomeline oxalate (LY246708), a potent SMRA, boosts phosphoinositide hydrolysis; key for Alzheimer's research.</p>Formula:C16H25N3O5SPurity:99.1%Color and Shape:SolidMolecular weight:371.45NKY80
CAS:<p>NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues.</p>Formula:C12H11N3O2Purity:99.88%Color and Shape:SolidMolecular weight:229.23Oxotremorine M iodide
CAS:<p>Oxotremorine M iodide (Oxotremorine methiodide) is an agonist of mAChR and potentiates NMDA receptors.</p>Formula:C11H19IN2OPurity:99.57%Color and Shape:SolidMolecular weight:322.19Iperoxo
CAS:<p>Iperoxo (Iperoxo iodide) is an agonist of Muscarinic AChR and can be used to probe activation-related conformational transitions of muscarinic receptors.</p>Formula:C10H17IN2O2Purity:99.81%Color and Shape:SolidMolecular weight:324.16Aceclidine
CAS:<p>Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular</p>Formula:C9H15NO2Purity:>99.99%Color and Shape:SolidMolecular weight:169.22Posatirelin
CAS:<p>Posatirelin, a synthetic peptide, modulates and nourishes brain systems, aiding in vascular dementia research.</p>Formula:C17H28N4O4Purity:98.08% - 98.87%Color and Shape:SolidMolecular weight:352.43GSK233705
CAS:<p>GSK233705, a muscarinic antagonist, is used to prevent/treat COPD and asthma.</p>Formula:C24H29BrN2Purity:99.87% - 99.98%Color and Shape:SolidMolecular weight:425.4Temiverine hydrochloride
CAS:<p>Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of the functions of atropine.</p>Formula:C24H36ClNO3Purity:99.26% - 99.43%Color and Shape:SolidMolecular weight:422Zamifenacin fumarate
CAS:<p>Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.</p>Formula:C31H33NO7Purity:99.88%Color and Shape:SolidMolecular weight:531.6LG 50643
CAS:<p>LG 50643 is a muscarinic antagonist.</p>Formula:C24H34INO2Purity:98%Color and Shape:SolidMolecular weight:495.44LY2033298
CAS:<p>LY2033298 enhances oximoline's effect on hamster circadian rhythms, aiding neurosystem disorders.</p>Formula:C13H14ClN3O2SPurity:99.06%Color and Shape:SolidMolecular weight:311.79ICL-CCIC-0019
CAS:<p>ICL-CCIC-0019 inhibits ChoKα, causes G1 arrest, ER stress, and cancer cell apoptosis.</p>Formula:C26H44Br2N4Purity:99.54%Color and Shape:SolidMolecular weight:572.46PTAC oxalate
CAS:<p>muscarinic receptor ligand</p>Formula:C14H21N3O4S2Purity:98%Color and Shape:SolidMolecular weight:359.46N-Demethyl MK-6884
CAS:<p>N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.</p>Formula:C24H23N5OColor and Shape:SolidMolecular weight:397.47Adenylyl cyclase-IN-1
CAS:<p>Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].</p>Formula:C9H8N2S3Color and Shape:SolidMolecular weight:240.37Tiotropium Bromide hydrate
CAS:<p>Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.</p>Formula:C19H24BrNO5S2Purity:98.44% - 99.41%Color and Shape:SolidMolecular weight:490.43Timepidium bromide
CAS:<p>Timepidium bromide is an agent of anticholinergic.</p>Formula:C17H22BrNOS2Purity:98%Color and Shape:SolidMolecular weight:400.4APS3
CAS:<p>APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].</p>Formula:C18H7Cl2F6N5O5S2Color and Shape:SolidMolecular weight:622.31VU0453595
CAS:<p>VU0453595 is a M1 positive allosteric modulator (PAM).</p>Formula:C18H15FN4OPurity:99.91%Color and Shape:SolidMolecular weight:322.34VU 0255035
CAS:<p>VU 0255035 is a highly selective, competitive and brain penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM.</p>Formula:C18H20N6O3S2Purity:98.09% - 98.1%Color and Shape:SolidMolecular weight:432.52ABT-418 hydrochloride
CAS:<p>ABT-418 HCl enhances cognition and reduces anxiety as a selective nAChRs agonist, researched for Alzheimer's.</p>Formula:C9H15ClN2OColor and Shape:SolidMolecular weight:202.68Muscarine tosylate
CAS:<p>Muscarine ((+)-Muscarine) tosylate, a prototype mAChR agonist, serves as a parasympathetic nervous system stimulant and is recognized for its toxic properties [1] [2].</p>Formula:C16H27NO5SColor and Shape:SolidMolecular weight:345.45AR420626
CAS:<p>AR420626: selective FA3R agonist, guards against SALS, effects blocked by BHB, a FA3R antagonist.</p>Formula:C21H18Cl2N2O3Purity:98.62%Color and Shape:SolidMolecular weight:417.29mAChR antagonist 1
CAS:<p>Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes,</p>Formula:C19H22N2O2Color and Shape:SolidMolecular weight:310.39Homatropine hydrochloride
CAS:<p>Homatropine hydrochloride is an orally active anticholinergic agent that induces rapid pupil dilation with cycloplegic effects and possesses antitussive</p>Formula:C16H22ClNO3Color and Shape:SolidMolecular weight:311.83-Bromocytisine
CAS:<p>3-Bromocytisine ((-)-3-Bromocytisine) is an effective agonist of nAChR (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7).</p>Formula:C11H13BrN2OPurity:99.974%Color and Shape:SolidMolecular weight:269.14UFP-512
CAS:<p>UFP-512 is a selective delta-opioid (DOP) receptor agonist.</p>Formula:C31H33N5O5Purity:98%Color and Shape:SolidMolecular weight:555.62A-424274
CAS:<p>A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.</p>Formula:C14H15N3Purity:98%Color and Shape:SolidMolecular weight:225.29L 687306
CAS:<p>L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors.</p>Formula:C11H15N3OColor and Shape:SolidMolecular weight:205.26BMS-933043
CAS:<p>BMS-933043: α7 nAChR partial agonist, binds rat (Ki=3.3 nM) & human (Ki=8.1 nM), agonist with EC50=23.4 nM (calcium assay), 0.14-0.29 μM (electrophysiology).</p>Formula:C16H19N7OPurity:98%Color and Shape:SolidMolecular weight:325.37Tematropium
CAS:<p>Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.</p>Formula:C21H31NO8SPurity:99.89%Color and Shape:SolidMolecular weight:457.54(-)-Cevimeline hydrochloride hemihydrate
<p>(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.</p>Formula:C10H19ClNO1·5SPurity:98%Color and Shape:SolidMolecular weight:244.78Lu 26-046
CAS:<p>Lu 26-046 is a muscarinic receptor agonist.</p>Formula:C10H12N2OSColor and Shape:SolidMolecular weight:208.28(+)-Sparteine sulfate pentahydrate
<p>(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.</p>Formula:C15H38N2O9SColor and Shape:SolidMolecular weight:422.54(+)-Cevimeline hydrochloride hemihydrate
<p>(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.</p>Formula:C10H19ClNO1·5SPurity:98%Color and Shape:SolidMolecular weight:244.78Dihydro-β-erythroidine hydrobromide
CAS:<p>Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).</p>Formula:C16H22BrNO3Purity:98%Color and Shape:White SolidMolecular weight:356.26WIN 62577
CAS:<p>WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.</p>Formula:C29H31N3OColor and Shape:SolidMolecular weight:437.576Metoquizine
CAS:<p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>Formula:C22H27N5OPurity:98%Color and Shape:SolidMolecular weight:377.48(S)-Albuterol
CAS:<p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>Formula:C13H21NO3Color and Shape:SolidMolecular weight:239.311nAChR antagonist 1
CAS:<p>Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.</p>Formula:C19H22N4O2Color and Shape:SolidMolecular weight:338.41,9-Dideoxyforskolin
CAS:<p>The compound is an inactive analog of forskolin(an adenylyl cyclase activator).</p>Formula:C22H34O5Purity:98%Color and Shape:SolidMolecular weight:378.5LY593093
CAS:<p>LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.</p>Formula:C32H30FN3O2Purity:98%Color and Shape:SolidMolecular weight:507.6CHF-6366
CAS:<p>CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.</p>Formula:C42H48N6O8Color and Shape:SolidMolecular weight:764.87VU6007496
CAS:<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Formula:C25H27N5O2Color and Shape:SolidMolecular weight:429.51UB 165
CAS:<p>Subtype-selective nicotinic agonist</p>Formula:C13H15ClN2Purity:98%Color and Shape:SolidMolecular weight:234.72VU6016235
CAS:<p>VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.</p>Formula:C21H22N4OSColor and Shape:SolidMolecular weight:378.49TDI-11861
CAS:<p>TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.</p>Formula:C22H25ClF2N6O3Color and Shape:SolidMolecular weight:494.92Dihydro-β-erythroidine
CAS:<p>Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolytic</p>Formula:C16H21NO3Color and Shape:SolidMolecular weight:275.34TAAR1 agonist 2
CAS:<p>TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.</p>Formula:C9H11NOColor and Shape:SolidMolecular weight:149.19VU6005806
CAS:<p>VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.</p>Formula:C17H16F3N7O2SPurity:98%Color and Shape:SolidMolecular weight:439.41AChE/BChE-IN-10
CAS:<p>AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.</p>Formula:C26H30N2O2Purity:99.55% - 99.88%Color and Shape:SoildMolecular weight:402.53MG 624
CAS:<p>neuronal α7 nAChR antagonist</p>Formula:C22H30INOColor and Shape:SolidMolecular weight:451.38VU6000918
CAS:<p>VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.</p>Formula:C18H17F2N5OSColor and Shape:SolidMolecular weight:389.42Lupinine
CAS:<p>Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.</p>Formula:C10H19NOPurity:99.95%Color and Shape:SolidMolecular weight:169.26Oxitropium Bromide
CAS:<p>Oxitropium bromide, a mAChR blocker, treats asthma and COPD as an anticholinergic bronchodilator.</p>Formula:C19H26BrNO4Purity:98%Color and Shape:SolidMolecular weight:412.32
