AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Found 574 products of "AChR"
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(±)-Darifenacin
CAS:<p>(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor.</p>Formula:C28H30N2O2Color and Shape:SolidMolecular weight:426.55ABT-107
CAS:<p>ABT-107: α7 neuronal receptor agonist; protects rats' brains from 6-OHDA-induced damage.</p>Formula:C19H20N4OColor and Shape:SolidMolecular weight:320.396VU0467485
CAS:<p>VU0467485 boosts ACh at M4 receptors (EC50: 26.6 nM rat, 78.8 nM human), selective for M4 over M1/2/3/5.</p>Formula:C17H17FN4O2SPurity:98%Color and Shape:SolidMolecular weight:360.41Clorprenaline
CAS:<p>Clorprenaline is a β-adrenergic receptor agonist that activates adenylate cyclase, relaxation of bronchial smooth muscle cells. anti-inflammatory.</p>Formula:C11H16ClNOPurity:98.9%Color and Shape:SolidMolecular weight:213.7NSC 23766
CAS:<p>NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.</p>Formula:C24H35N7Purity:99.49%Color and Shape:SolidMolecular weight:421.58NKH477
CAS:<p>NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity.</p>Formula:C27H44ClNO8Purity:98% - 98%Color and Shape:SolidMolecular weight:546.09Cevimeline
CAS:<p>Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.</p>Formula:C10H17NOSColor and Shape:Off-White SolidMolecular weight:199.31Pirmenol hydrochloride
CAS:<p>Pirmenol hydrochloride functions by inhibiting I_K.ACh through the blockade of muscarinic receptors, demonstrating a potent effect with an IC_50 value of 0.1 μM</p>Formula:C22H31ClN2OColor and Shape:SolidMolecular weight:374.95Tolterodine
CAS:<p>Tolterodine ((R)-(+)-Tolterodine) is an mACh antagonist used in the treatment of detrusor instability and overactive bladder syndrome.</p>Formula:C22H31NOPurity:99.71%Color and Shape:White Like Or Light Brown Crystalline PowderMolecular weight:325.49Sabcomeline hydrochloride
CAS:<p>Sabcomeline is a selective M1 receptor partial agonist.</p>Formula:C10H16ClN3OColor and Shape:SolidMolecular weight:229.71DL-Cystine
CAS:<p>DL-Cystine is a cysteine derivative that inhibits endothelial cell proliferation by regulating TGFβ1. a GPR inhibitor and nAChR agonist .</p>Formula:C6H12N2O4S2Color and Shape:SolidMolecular weight:240.3NS3861 fumarate
CAS:<p>NS3861 fumarate, a partial α3β4 nAChR agonist, binds α3β2, α4β4, α4β2 with Ki values of 0.62, 25, 7.8, 55 nM.</p>Formula:C16H18BrNO4SColor and Shape:SolidMolecular weight:400.29Tebanicline dihydrochloride
CAS:<p>Tebanicline dihydrochloride: oral analgesic, nAChR modulator, Ki=37 pM at α4β2 receptors, inhibits cytisine binding.</p>Formula:C9H13Cl3N2OColor and Shape:SolidMolecular weight:271.57Tebanicline hydrochloride
CAS:<p>Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug.</p>Formula:C9H12Cl2N2OPurity:91.74% - 98.71%Color and Shape:SolidMolecular weight:235.11VU0119498
CAS:<p>VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.</p>Formula:C15H10BrNO2Purity:97.56%Color and Shape:SolidMolecular weight:316.15VU0152100
CAS:<p>VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).</p>Formula:C18H19N3O2SPurity:99.56%Color and Shape:SolidMolecular weight:341.43Nitrobenzylthioinosine
CAS:<p>Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.</p>Formula:C17H17N5O6SPurity:99.69% - 99.74%Color and Shape:Off-White SolidMolecular weight:419.41VU0467154
CAS:<p>VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor.</p>Formula:C17H15F3N4O3S2Purity:98.28% - 99.51%Color and Shape:SolidMolecular weight:444.45NS9283
CAS:<p>NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.</p>Formula:C14H8N4OPurity:99.12%Color and Shape:SolidMolecular weight:248.24BNC210
CAS:<p>BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.</p>Formula:C17H23N3O3Purity:97.05% - >99.99%Color and Shape:SolidMolecular weight:317.38ML380
CAS:<p>ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).</p>Formula:C23H25F3N4O3SPurity:99.69%Color and Shape:SolidMolecular weight:494.53Isopropamide Iodide
CAS:<p>Isopropamide iodide: long-acting anticholinergic, treats peptic ulcers, GI disorders, Alzheimer's.</p>Formula:C23H33IN2OPurity:99.67%Color and Shape:SolidMolecular weight:480.43Mc-Val-Ala-PAB
CAS:<p>Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).</p>Formula:C25H34N4O6Purity:98.34% - 99.24%Color and Shape:SolidMolecular weight:486.56Donepezil Hydrochloride
CAS:<p>Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).</p>Formula:C24H29NO3·HClPurity:99.55% - 99.8%Color and Shape:White To Off-White Crystalline SolidMolecular weight:415.96Nitenpyram
CAS:<p>Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.</p>Formula:C11H15ClN4O2Purity:99.03%Color and Shape:Light-Yellow CrystalMolecular weight:270.72Mecamylamine hydrochloride
CAS:<p>Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension.</p>Formula:C11H22ClNPurity:99.76% - >99.99%Color and Shape:White SolidMolecular weight:203.75Solifenacin hydrochloride
CAS:<p>Solifenacin Hcl is a muscarinic receptor antagonist.</p>Formula:C23H27ClN2O2Purity:98%Color and Shape:SolidMolecular weight:398.93Encenicline
CAS:<p>Encenicline (EVP-6124), a selective α7 nAChRs agonist, targets cognitive impairment in schizophrenia and Alzheimer's.</p>Formula:C16H17ClN2OSPurity:99.20%Color and Shape:SolidMolecular weight:320.84VU0238441
CAS:<p>VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.</p>Formula:C16H9ClF3NO2Purity:100%Color and Shape:SolidMolecular weight:339.7Solifenacin
CAS:<p>Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0,</p>Formula:C23H26N2O2Purity:99.87%Color and Shape:SolidMolecular weight:362.46Pempidine
CAS:<p>Pempidine (1,2,2,6,6-Pentamethylpiperidine) is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.</p>Formula:C10H21NPurity:98.18% - 99.28%Color and Shape:Colorless - Light Yellow Clear LiquidMolecular weight:155.28Oxyphencyclimine Hydrochloride
CAS:<p>Oxyphencyclimine Hydrochloride (Ulcociclinina) is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.</p>Formula:C20H29ClN2O3Purity:99.55%Color and Shape:SolidMolecular weight:380.91Mecamylamine
CAS:<p>Mecamylamine: oral, noncompetitive nAChR blocker, crosses blood-brain barrier, for neuropsychiatric and hypertension research.</p>Formula:C11H21NColor and Shape:SolidMolecular weight:167.29Propiverine
CAS:<p>Propiverine reduces muscle spasms by limiting calcium influx, targeting bladder smooth muscles, aiding OAB research.</p>Formula:C23H29NO3Color and Shape:SolidMolecular weight:367.48DMAB-anabaseine dihydrochloride
CAS:<p>DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) is an α7-containing</p>Formula:C19H23Cl2N3Purity:99.91%Color and Shape:SolidMolecular weight:364.31NS 1738
CAS:<p>NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)</p>Formula:C14H9Cl2F3N2O2Purity:99.11%Color and Shape:SolidMolecular weight:365.13Ethyl (triphenylphosphoranylidene) acetate
CAS:<p>Ethyl (triphenylphosphoranylidene) acetate ((Carbethoxymethylene)triphenylphosphorane) may act as an cholinesterase inhibitor that inhibits AChE and BChE.</p>Formula:C22H21O2PPurity:97.985%Color and Shape:White Or Slight Yellow PowderMolecular weight:348.37Oxyphenonium bromide
CAS:<p>Oxyphenonium bromide is an anticholinergic used to study and treat ulcers and relieve visceral spasms.</p>Formula:C21H34BrNO3Purity:98.96%Color and Shape:SolidMolecular weight:428.404Propantheline
CAS:<p>Propantheline: oral muscarinic receptor blocker for smooth muscle issues, hyperhidrosis, and bladder control.</p>Formula:C23H30NO3Color and Shape:SolidMolecular weight:368.49MC-Val-Cit-PABC-PNP
CAS:<p>MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker.</p>Formula:C35H43N7O11Purity:97.2% - 98.055%Color and Shape:SolidMolecular weight:737.76Mivacurium dichloride
CAS:<p>Mivacurium dichloride: non-depolarizing, quick-acting muscle relaxant for minor surgeries and tracheal intubation.</p>Formula:C58H80Cl2N2O14Purity:99.2% - 99.48%Color and Shape:Off-White SolidMolecular weight:1100.17Bestim
CAS:<p>Bestim is an immunomodulatory dipeptide that is synthetic.</p>Formula:C16H19N3O5Purity:99.76%Color and Shape:SolidMolecular weight:333.34Fesoterodine
CAS:<p>Fesoterodine is an oral mAChR blocker (pKi: 7.3-8.0) for M1-M5, used to treat OAB.</p>Formula:C26H37NO3Purity:97.1%Color and Shape:SolidMolecular weight:411.58Cyclopentolate Hydrochloride
CAS:<p>Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.</p>Formula:C17H26ClNO3Purity:99.91%Color and Shape:SolidMolecular weight:327.85Rivanicline hemioxalate
<p>Rivanicline hemioxalate is a selective α4β2 nicotinic receptor agonist (K i =26 nM), over 1,000x preference to α7 (K i =3.6 μM), with limited side effects.</p>Formula:C12H16N2O4Purity:98%Color and Shape:SolidMolecular weight:207.23A-867744
CAS:<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Formula:C20H19ClN2O3SPurity:95.66%Color and Shape:SolidMolecular weight:402.89VU0152099
CAS:<p>VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).</p>Formula:C18H17N3O3SPurity:98.46%Color and Shape:SolidMolecular weight:355.41Encenicline hydrochloride
CAS:<p>Encenicline hydrochloride (EVP-6124 hydrochloride) is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).</p>Formula:C16H17ClN2OS·HClPurity:98.34% - 99.85%Color and Shape:SolidMolecular weight:357.3Coluracetam
CAS:<p>Coluracetam (MKC-231)(MKC-231) is a Choline Uptake Enhancer.</p>Formula:C19H23N3O3Purity:99.96%Color and Shape:SolidMolecular weight:341.4suvn-911
CAS:<p>suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.</p>Formula:C11H14Cl2N2OPurity:98.88%Color and Shape:SolidMolecular weight:261.15
