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AChR

AChR

Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.

Found 617 products of "AChR"

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  • ASP8302
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    ASP8302

    CAS:
    ASP8302 is an allosteric potentiator of the muscarinic M3 receptor. It enhances urination efficiency and reduces residual urine volume in two rat models of voiding dysfunction. ASP8302 is useful for investigating diseases associated with bladder dysfunction.
    Formula:C26H32ClN7O3S2
    Color and Shape:Solid
    Molecular weight:590.16

    Ref: TM-T88183

  • Muscarine tosylate
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    Muscarine tosylate

    CAS:
    Muscarine ((+)-Muscarine) tosylate, a prototype mAChR agonist, serves as a parasympathetic nervous system stimulant and is recognized for its toxic properties [1] [2].
    Formula:C16H27NO5S
    Color and Shape:Solid
    Molecular weight:345.45

    Ref: TM-T84726

  • Hydroxy Varenicline
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    Hydroxy Varenicline

    CAS:
    Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.
    Formula:C13H13N3O
    Color and Shape:Solid
    Molecular weight:227.267

    Ref: TM-T85294

  • VU 0255035
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    VU 0255035

    CAS:
    <p>VU 0255035 is a highly selective, competitive and brain penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM.</p>
    Formula:C18H20N6O3S2
    Purity:98.09% - 98.1%
    Color and Shape:Solid
    Molecular weight:432.52

    Ref: TM-T23508

  • Cynandione A
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    Cynandione A

    CAS:
    Cynandione A is an acetophenone derived from Cynanchum wilfordii with anti-inflammatory activity.
    Formula:C16H14O6
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:302.28

    Ref: TM-T70277

  • PTAC oxalate
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    PTAC oxalate

    CAS:
    muscarinic receptor ligand
    Formula:C14H21N3O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:359.46

    Ref: TM-T23205

  • VU0453595
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    VU0453595

    CAS:
    <p>VU0453595 is a M1 positive allosteric modulator (PAM).</p>
    Formula:C18H15FN4O
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:322.34

    Ref: TM-T29137

  • UFP-512
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    UFP-512

    CAS:
    UFP-512 is a selective delta-opioid (DOP) receptor agonist.
    Formula:C31H33N5O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:555.62

    Ref: TM-T29046

  • A-424274
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    A-424274

    CAS:
    A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.
    Formula:C14H15N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:225.29

    Ref: TM-T23594

  • Tematropium
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    Tematropium

    CAS:
    Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.
    Formula:C21H31NO8S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:457.54

    Ref: TM-T10732

  • CymitQuimica logo
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    (+)-Sparteine sulfate pentahydrate

    (+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.
    Formula:C15H38N2O9S
    Color and Shape:Solid
    Molecular weight:422.54

    Ref: TM-T62265

  • WIN 62577
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    WIN 62577

    CAS:
    WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.
    Formula:C29H31N3O
    Color and Shape:Solid
    Molecular weight:437.576

    Ref: TM-T206261

  • (S)-Albuterol
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    (S)-Albuterol

    CAS:
    <p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>
    Formula:C13H21NO3
    Color and Shape:Solid
    Molecular weight:239.311

    Ref: TM-T206288

  • CymitQuimica logo
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    nAChR antagonist 1

    CAS:
    Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.
    Formula:C19H22N4O2
    Color and Shape:Solid
    Molecular weight:338.4

    Ref: TM-T61064

  • Dihydro-β-erythroidine hydrobromide
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    Dihydro-β-erythroidine hydrobromide

    CAS:
    Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).
    Formula:C16H22BrNO3
    Purity:98%
    Color and Shape:White Solid
    Molecular weight:356.26

    Ref: TM-T11041

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    p-F-HHSiD hydrochloride

    CAS:
    p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).
    Formula:C20H33ClFNOSi
    Molecular weight:386.019

    Ref: TM-T204865

  • VU6007496
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    VU6007496

    CAS:
    <p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>
    Formula:C25H27N5O2
    Color and Shape:Solid
    Molecular weight:429.51

    Ref: TM-T200762

  • TAAR1 agonist 2
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    TAAR1 agonist 2

    CAS:
    TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.
    Formula:C9H11NO
    Color and Shape:Solid
    Molecular weight:149.19

    Ref: TM-T200140

  • VU6016235
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    VU6016235

    CAS:
    VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.
    Formula:C21H22N4OS
    Color and Shape:Solid
    Molecular weight:378.49

    Ref: TM-T201326

  • TDI-11861
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    TDI-11861

    CAS:
    TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.
    Formula:C22H25ClF2N6O3
    Color and Shape:Solid
    Molecular weight:494.92

    Ref: TM-T73297