PAI-1
Plasminogen Activator Inhibitor-1 (PAI-1) is a serine protease inhibitor that regulates fibrinolysis by inhibiting tissue plasminogen activator (tPA) and urokinase (uPA). Elevated levels of PAI-1 are associated with an increased risk of thrombosis, cardiovascular diseases, and metabolic syndrome. PAI-1 inhibitors are being investigated for their potential to treat these conditions. At CymitQuimica, we offer PAI-1 inhibitors to support your research in hematology, cardiovascular health, and metabolic diseases.
Found 25 products of "PAI-1"
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Upamostat
CAS:<p>Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.</p>Formula:C32H47N5O6SPurity:99.41%Color and Shape:SolidMolecular weight:629.81Angstrom6
CAS:<p>Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade</p>Formula:C39H62N10O15Purity:99.36%Color and Shape:SolidMolecular weight:910.97CT140
<p>CT140 is a human IgG4 monoclonal antibody (mAb) that specifically targets PAI-1. The suggested isotype control for this compound is Human IgG4 kappa, Isotype Control.</p>Color and Shape:Odour LiquidGGACK hydrochloride
<p>GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Formula:C14H26Cl2N6O5Color and Shape:SolidMolecular weight:428.13417Nattokinase
CAS:<p>Nattokinase is a serine protease derived from nattō, oral， fibrinolytic/anticoagulant properties. It degrades fibrin, fibrinolytic substrates, and PAI-1.</p>Color and Shape:SolidUK140
<p>UK140 is an inhibitor of the urokinase-type plasminogen activator (uPA), with Ki values of 0.20 µM for human uPA (huPA) and 2.79 µM for mouse uPA (muPA). UK140 is applicable in studies related to tumor metastasis.</p>Formula:C72H105N19O25S3Color and Shape:SolidMolecular weight:1732.91Bicyclic UK18
CAS:<p>Bicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA) with a Ki value of 53 nM.</p>Formula:C77H118N26O25S3Color and Shape:SolidMolecular weight:1904.11UK-371804
CAS:<p>UK-371804: potent uPA blocker; candidate for chronic skin ulcer preclinical studies.</p>Formula:C14H16ClN5O4SPurity:95.81% - 99.77%Color and Shape:SolidMolecular weight:385.83Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Formula:C18H20O5Purity:99.33% - 99.86%Color and Shape:SolidMolecular weight:316.35TM5441
CAS:<p>TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.Cost-effective and quality-assured.Cost-effective and quality-assured.</p>Formula:C21H17ClN2O6Purity:97.62% - 99.09%Color and Shape:SolidMolecular weight:428.82TM5007
CAS:<p>TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).</p>Formula:C24H20N2O6S4Purity:96.91%Color and Shape:SolidMolecular weight:560.69Tiplaxtinin
CAS:<p>Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.</p>Formula:C24H16F3NO4Purity:99.16% - 99.93%Color and Shape:SolidMolecular weight:439.38Toddalolactone
CAS:<p>Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.</p>Formula:C16H20O6Purity:99.06% - 99.85%Color and Shape:SolidMolecular weight:308.33TM5275 sodium
CAS:<p>TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).</p>Formula:C28H27ClN3NaO5Purity:98.8% - 99.74%Color and Shape:SolidMolecular weight:543.98MDI-2268
CAS:<p>MDI-2268, an inhibitor of plasma kallikrein inhibitor 1 (PAI-1), exhibits strong antithrombotic properties. It plays a role in regulating blood coagulation by promoting fibrinolysis and is applicable in research related to deep vein thrombosis.</p>Formula:C10H10F3N3O3Color and Shape:SolidMolecular weight:277.20SK-216
CAS:<p>SK-216,PAI-1 inhibitor. Reduces tumor angiogenesis. Inhibits VEGF-induced endothelial cell migration. Alleviates pulmonary fibrosis.</p>Formula:C29H29NNa2O6Purity:98.29%Color and Shape:SolidMolecular weight:533.52UK-371804 HCl
CAS:<p>UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-</p>Formula:C14H17Cl2N5O4SPurity:98%Color and Shape:SolidMolecular weight:422.29Diaplasinin
CAS:<p>Diaplasinin (PAI-749) is a potent inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity, used in cardiovascular disease research.</p>Formula:C32H31N5OPurity:99.02%Color and Shape:SolidMolecular weight:501.62Aleplasinin
CAS:<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Formula:C28H27NO3Purity:99.21%Color and Shape:SolidMolecular weight:425.52AZ3976
CAS:<p>AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.</p>Formula:C15H19N5O3Purity:98.14%Color and Shape:SolidMolecular weight:317.34PPACK
CAS:<p>PPACK: synthetic peptide, irreversibly inhibits thrombin (Ki = 0.24 nM), prevents platelet activation.</p>Formula:C21H31ClN6O3Purity:98%Color and Shape:SolidMolecular weight:450.96GW-6604
CAS:<p>GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.</p>Formula:C19H14N4Purity:99.6%Color and Shape:SolidMolecular weight:298.34ZK824190
CAS:<p>ZK824190: oral uPA inhibitor, IC50 - uPA 237 nM, tPA 1600 nM, Plasmin 1850 nM.</p>Formula:C22H20F2N2O4Purity:98.84%Color and Shape:SolidMolecular weight:414.4BT-114143
CAS:<p>BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.</p>Formula:C8H11N2O3PColor and Shape:SolidMolecular weight:214.158GGACK
CAS:<p>GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Formula:C14H25ClN6O5Molecular weight:392.84
