Acetyl-CoA Carboxylase

CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat

PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.

Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Quizalofop-ethyl is a post-emergence herbicide for grass weeds in broadleaf crops. It works by inhibiting the ACCase enzyme.

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2,

Tralkoxydim (Tralkoxydime) is an alkyl ketone herbicide. Tralkoxydim works as an ACCase inhibitor.

PF-3: potent ACC1/2 inhibitor; IC50: 22 nM (ACC1), 48 nM (ACC2); anti-cancer research potential.

Propaquizafop, a phenoxyisopropionic acid derivative, is used as a herbicide.

Acetyl-CoA Carboxylase-IN-1 (ACC-IN-1) is a potent acetyl-CoA carboxylase (ACC) inhibitor with antibacterial activity, used in metabolic disease research.

Clethodim is a selective herbicide inhibiting acetyl-CoA carboxylase, effective on grasses with low environmental persistence and moderate toxicity to wildlife.

hACC2-IN-1 is a potent inhibitor of acetyl coenzyme A carboxylase 2 (ACC2) with an IC50 value of 2.5 μM for hACC2. hACC2-IN-1 has potential for obesity studies.

A-908292: potent ACC2 inhibitor with 38 nM IC50, useful for studying fatty acid metabolism.

ACC1/2-IN-1 is a potent inhibitor of ACC1/2 and acts on ACC1 (IC50: 98.06 nM) and ACC2 (IC50: 29.43 nM). ACC1/2-IN-1 can be used in cancer research.

S-2E, an oral inhibitor of HMG-CoA reductase/acetyl-CoA carboxylase, treats hyperlipidemia.

Quizalofop (Xylafop) is a reagent of biochemical.

Quizalofop-P, a selective herbicide, is absorbed by weed stems and leaves before translocating both upward and downward within the plant, concentrating in

AD-5584, an ACSS2 inhibitor with blood-brain permeability, significantly reduces lipid storage and colony formation while increasing cell death, demonstrating antitumor activity [1].

AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).

THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH).