Acetyl-CoA Carboxylase

S-2E, an oral inhibitor of HMG-CoA reductase/acetyl-CoA carboxylase, treats hyperlipidemia.

Quizalofop-P, a selective herbicide, is absorbed by weed stems and leaves before translocating both upward and downward within the plant, concentrating in

ACC1/2-IN-1 is a potent inhibitor of ACC1/2 and acts on ACC1 (IC50: 98.06 nM) and ACC2 (IC50: 29.43 nM). ACC1/2-IN-1 can be used in cancer research.

AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).

ACC1/2-IN-3 (example 66) is an inhibitor targeting both ACC1 and ACC2, with IC₅₀ values of 1-10 nM for each. It is applicable in studies related to ACC-mediated conditions, such as metabolic diseases.

ACC-IN-1 (Compound B1) is an allosteric inhibitor of acetyl-CoA carboxylase (ACC). It targets ACC to regulate lipid metabolism, potentially improving liver steatosis and inflammation associated with non-alcoholic steatohepatitis (NASH).

LCB-2122 is an adenosine-like nucleoside analog featuring a C2'-stereoisomeric all-carbon quaternary carbon center. It inhibits doxorubicin-induced myocardial apoptosis with an IC50 value of 0.5 μM and also suppresses imatinib-induced apoptosis. LCB-2122 activates the AMPK signaling pathway, inducing the phosphorylation of AMPK and its downstream substrate acetyl-CoA carboxylase (ACC). Additionally, LCB-2122 alleviates mitochondrial damage caused by doxorubicin and is used in heart failure research.

CKBA, a derivative of AKBA, acts as an acetyl-CoA carboxylase 1 (ACC1) inhibitor with an IC50 of 5.02 μM. It inhibits Th17 cell differentiation, displaying IC50 values of 3.28 μM in mouse cells and 3.61 μM in human cells. CKBA ointment significantly alleviates psoriasis-like inflammation in mice and can be used for psoriasis research.

QPP-I-6, an inhibitor of acetyl-coenzyme A carboxylase (ACCase), exhibits herbicidal activity by inducing cell membrane permeability [1].

THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH).

Moiramide B is an acetyl coenzyme A carboxylase inhibitor with antimicrobial activity, strongly inhibiting Gram-positive bacteria.