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Cysteine Protease

Cysteine Protease

Cysteine Protease inhibitors are compounds that target and inhibit cysteine proteases, a class of enzymes that break down proteins by cleaving peptide bonds in which a cysteine residue acts as the nucleophile. These enzymes are involved in various physiological processes, including apoptosis, immune response, and protein turnover. Cysteine protease inhibitors are crucial for studying diseases such as cancer, neurodegenerative disorders, and parasitic infections. At CymitQuimica, we provide cysteine protease inhibitors to aid your research in proteolysis, cellular regulation, and drug discovery.

Found 96 products of "Cysteine Protease"

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  • GB111-NH2

    CAS:
    <p>GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].</p>
    Formula:C33H39N3O6
    Color and Shape:Solid
    Molecular weight:573.68
  • Verducatib

    CAS:
    <p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>
    Formula:C31H35FN4O3
    Color and Shape:Solid
    Molecular weight:530.633
  • Cathepsin K inhibitor 2

    CAS:
    <p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61
  • BI-1915

    CAS:
    <p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>
    Formula:C21H37N5O3
    Color and Shape:Solid
    Molecular weight:407.55
  • Cathepsin C-IN-3


    <p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>
    Formula:C28H21F3N6OS
    Color and Shape:Solid
    Molecular weight:546.57
  • RO5461111

    CAS:
    <p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) &amp; 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation &amp; lupus nephritis.</p>
    Formula:C27H24F6N4O4S
    Color and Shape:Solid
    Molecular weight:614.56
  • SID 26681509 quarterhydrate


    <p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>
    Formula:C27H35N5O6S
    Color and Shape:Solid
    Molecular weight:544.16
  • Dual Cathepsin L/JAK-IN-1

    CAS:
    <p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>
    Formula:C19H18ClN5
    Color and Shape:Solid
    Molecular weight:351.833
  • Cathepsin C-IN-5

    CAS:
    <p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>
    Formula:C21H17ClN6OS
    Color and Shape:Solid
    Molecular weight:436.92
  • Z-FY-CHO

    CAS:
    <p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>
    Formula:C26H26N2O5
    Purity:95.88%
    Color and Shape:Solid
    Molecular weight:446.5
  • CTSL/CAPN1-IN-2

    CAS:
    <p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>
    Formula:C34H40N4O6
    Color and Shape:Solid
    Molecular weight:600.7
  • CatD-IN-1

    CAS:
    <p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>
    Formula:C18H18Cl2N4O5
    Color and Shape:Solid
    Molecular weight:441.265
  • Cathepsin C-IN-4


    <p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>
    Formula:C21H14ClF3N4S
    Color and Shape:Solid
    Molecular weight:446.88
  • MIV-247

    CAS:
    <p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39
  • PD 151746

    CAS:
    <p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25
  • ALLM

    CAS:
    <p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product