Cysteine Protease
Cysteine Protease inhibitors are compounds that target and inhibit cysteine proteases, a class of enzymes that break down proteins by cleaving peptide bonds in which a cysteine residue acts as the nucleophile. These enzymes are involved in various physiological processes, including apoptosis, immune response, and protein turnover. Cysteine protease inhibitors are crucial for studying diseases such as cancer, neurodegenerative disorders, and parasitic infections. At CymitQuimica, we provide cysteine protease inhibitors to aid your research in proteolysis, cellular regulation, and drug discovery.
Found 111 products of "Cysteine Protease"
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PMSF
CAS:PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Formula:C7H7FO2SPurity:97.75% - 99.88%Color and Shape:White To Cream SolidMolecular weight:174.19Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Color and Shape:Odour SolidN-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purity:99.88%Color and Shape:SolidMolecular weight:726.7Ac-PLVE-FMK
CAS:Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].Formula:C25H41FN4O7Purity:98%Color and Shape:SolidMolecular weight:528.61FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.
Formula:C48H58BF2N7O5Color and Shape:SolidMolecular weight:861.456056,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormula:C30H42N2O4SColor and Shape:SolidMolecular weight:526.73Z-Leu-Tyr-Chloromethylketone
CAS:Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Formula:C24H29ClN2O5Color and Shape:SolidMolecular weight:460.95Z-Arg-Arg-βNA acetate
CAS:Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.Formula:C32H43N9O6Color and Shape:SolidMolecular weight:649.74VK13
VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.Formula:C24H28N4O5Color and Shape:SolidMolecular weight:452.503Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purity:99.11%Color and Shape:SolidMolecular weight:395.38Ref: TM-T9710
1mg92.00€5mg192.00€10mg289.00€25mg522.00€50mg732.00€100mg1,018.00€1mL*10mM (DMSO)212.00€Cathepsin L-IN-5
CathepsinL-IN-5 (D6-3) is a potent inhibitor of Cathepsin L (CatL) with an IC50 value of 0.27 nM. It effectively blocks the function of CatL and significantly impedes the entry of SARS-CoV-2 pseudovirus into cells by inhibiting the cleavage of the spike protein. CathepsinL-IN-5 is applicable for research on infections.Hepcidin-1 (mouse)
CAS:Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Formula:C111H169N31O35S8Color and Shape:SolidMolecular weight:2754.24Z-Phe-Tyr(tBu)-diazomethylketone
CAS:Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formula:C31H34N4O5Color and Shape:SolidMolecular weight:542.636Cathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Formula:C24H35N3O5Molecular weight:445.25767Cathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formula:C85H122N22O19Color and Shape:SolidMolecular weight:1756.046Mpro/Cathepsin L-IN-1
Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.Formula:C24H32FN3O4Molecular weight:445.23768Mpro/Cathepsin L-IN-2
Mpro/Cathepsin L-IN-2 (Compound 1) is an irreversible dual inhibitor targeting the main protease of SARS-CoV-2 (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 shows potential for use in research related to COVID-19 and other coronavirus infections.Color and Shape:Odour SolidTacalcitol monohydrate
CAS:Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.Formula:C27H46O4Purity:99.284%Color and Shape:SolidMolecular weight:434.65PD150606
CAS:PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.Formula:C9H7IO2SPurity:98.19%Color and Shape:SolidMolecular weight:306.12Cathepsin D and E FRET Substrate acetate
Fluorogenic substrate for cathepsins D & E, not B/H/L; useful in their mechanistic studies.Formula:C86H124N22O21Purity:95.63%Color and Shape:SolidMolecular weight:1802.04Z-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formula:C26H25N3O6Color and Shape:SolidMolecular weight:475.49Gallinamide A TFA
CAS:Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].Formula:C33H53F3N4O9Color and Shape:SolidMolecular weight:706.79N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formula:C33H36N6O6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:612.68Z-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formula:C22H31N5O5Purity:98%Color and Shape:SolidMolecular weight:445.51Relacatib
CAS:Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formula:C27H32N4O6SColor and Shape:SolidMolecular weight:540.64Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormula:C24H35N5O4·xC2HF3O2Color and Shape:SolidLeupeptin
CAS:Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formula:C20H38N6O4Purity:98%Color and Shape:SolidMolecular weight:426.562Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Color and Shape:Odour SolidProtease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Color and Shape:Odour SolidRef: TM-L1100
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireCathepsin L-IN-3
CAS:Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.Formula:C41H49N7O4SColor and Shape:SolidMolecular weight:735.94LN5P45
LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1Formula:C13H15ClN2O2Color and Shape:SolidMolecular weight:266.72L-006235
CAS:L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Formula:C24H30N6O2SPurity:99.37%Color and Shape:SolidMolecular weight:466.6Ref: TM-T21616
2mg39.00€5mg60.00€10mg92.00€25mg177.00€50mg299.00€100mg432.00€200mg602.00€1mL*10mM (DMSO)62.00€CA-074 methyl ester
CAS:CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!Formula:C19H31N3O6Purity:97.26% - 99.58%Color and Shape:SolidMolecular weight:397.47MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purity:95.06%Color and Shape:SolidMolecular weight:382.45Ref: TM-T2470
1mg34.00€2mg49.00€5mg71.00€10mg90.00€25mg128.00€50mg167.00€100mg284.00€1mL*10mM (DMSO)75.00€LY 3000328
CAS:LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Formula:C25H29FN4O5Purity:97.83% - 99.54%Color and Shape:SolidMolecular weight:484.52Ref: TM-TQ0116
1mg90.00€2mg130.00€5mg198.00€10mg263.00€25mg462.00€50mg672.00€100mg945.00€1mL*10mM (DMSO)207.00€Odanacatib
CAS:Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.Formula:C25H27F4N3O3SPurity:98.53% - 99.53%Color and Shape:SolidMolecular weight:525.56Ref: TM-T6035
2mg35.00€5mg52.00€10mg80.00€25mg120.00€50mg188.00€100mg354.00€200mgTo inquire1mL*10mM (DMSO)60.00€Aloxistatin
CAS:Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.Formula:C17H30N2O5Purity:99.46% - 99.69%Color and Shape:SolidMolecular weight:342.43Balicatib
CAS:Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.Formula:C23H33N5O2Purity:97.78% - 98.17%Color and Shape:White To Off-White Solid PowderMolecular weight:411.54Ref: TM-T1850
2mg39.00€5mg58.00€10mg94.00€25mg212.00€50mg358.00€100mg572.00€200mg803.00€1mL*10mM (DMSO)64.00€KGP94
CAS:KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.Formula:C14H12BrN3OSPurity:99.6%Color and Shape:SolidMolecular weight:350.23Ref: TM-T27730
1mg65.00€5mg138.00€10mg215.00€25mg359.00€50mg510.00€100mg692.00€200mg928.00€1mL*10mM (DMSO)152.00€JTE-607
CAS:JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.Formula:C25H33Cl4N3O5Purity:97.88%Color and Shape:SolidMolecular weight:597.36Ref: TM-T27695
1mg42.00€5mg93.00€10mg150.00€25mg310.00€50mg492.00€100mg707.00€200mg973.00€1mL*10mM (DMSO)109.00€2-Cyanopyrimidine
CAS:2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)Formula:C5H3N3Purity:99.27%Color and Shape:Crystalline SolidMolecular weight:105.1E 64c
CAS:E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.Formula:C15H26N2O5Purity:98.73%Color and Shape:SolidMolecular weight:314.38(1S,2R)-Alicapistat
CAS:(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.Formula:C25H27N3O4Purity:99.60%Color and Shape:SoildMolecular weight:433.5Ref: TM-T60150
1mg64.00€5mg142.00€10mg197.00€25mg299.00€50mg400.00€100mg537.00€1mL*10mM (DMSO)167.00€S 2160
CAS:S 2160 is a synthetic chromogenic substrate for thrombin.Formula:C33H40N8O6Color and Shape:SolidMolecular weight:644.72Cathepsin Inhibitor 1
CAS:Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
Formula:C20H24ClN5O2Purity:99.78%Color and Shape:SolidMolecular weight:401.89GSK2793660 HCl
CAS:GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.Formula:C22H32ClN3O3Color and Shape:SolidMolecular weight:421.96Cysteine Protease inhibitor
CAS:Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine ProteaseFormula:C18H14N4OPurity:98%Color and Shape:SolidMolecular weight:302.33SSAA09E1
CAS:SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).Formula:C7H9N3S2Color and Shape:SolidMolecular weight:199.3Gü1303
CAS:Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41Cysteine protease inhibitor-2
CAS:Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.Formula:C13H5N5OPurity:98%Color and Shape:SolidMolecular weight:247.21
