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Cysteine Protease

Cysteine Protease

Cysteine Protease inhibitors are compounds that target and inhibit cysteine proteases, a class of enzymes that break down proteins by cleaving peptide bonds in which a cysteine residue acts as the nucleophile. These enzymes are involved in various physiological processes, including apoptosis, immune response, and protein turnover. Cysteine protease inhibitors are crucial for studying diseases such as cancer, neurodegenerative disorders, and parasitic infections. At CymitQuimica, we provide cysteine protease inhibitors to aid your research in proteolysis, cellular regulation, and drug discovery.

Found 96 products of "Cysteine Protease"

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  • VEL-0230

    CAS:
    <p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>
    Formula:C14H24NNaO5
    Color and Shape:Solid
    Molecular weight:309.33
  • ASPER-29

    CAS:
    <p>ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.</p>
    Formula:C31H29BrN2O5S
    Color and Shape:Solid
    Molecular weight:621.54
  • L-873724

    CAS:
    <p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>
    Formula:C23H26F3N3O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.53
  • CAA0225

    CAS:
    <p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>
    Formula:C28H29N3O5
    Color and Shape:Solid
    Molecular weight:487.55
  • MDL 27399

    CAS:
    <p>MDL 27399 suppresses human neutrophil cathepsin G.</p>
    Formula:C26H36N4O8
    Color and Shape:Solid
    Molecular weight:532.59
  • AM 4299 B

    CAS:
    <p>AM 4299 B is a novel inhibitor of a thiol protease.</p>
    Formula:C16H27N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:373.4
  • Cysteine Protease inhibitor hydrochloride

    CAS:
    <p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>
    Formula:C18H15ClN4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.79
  • NAAA-IN-2

    CAS:
    <p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>
    Formula:C11H13N3O2S
    Color and Shape:Solid
    Molecular weight:251.3
  • SSAA09E1

    CAS:
    <p>SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).</p>
    Formula:C7H9N3S2
    Color and Shape:Solid
    Molecular weight:199.3
  • SQ 32602

    CAS:
    <p>SQ 32602 is a cathepsin E inhibitor.</p>
    Formula:C32H52N3O7P
    Color and Shape:Solid
    Molecular weight:621.74
  • Dutacatib

    CAS:
    <p>Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.</p>
    Formula:C23H31N7O
    Color and Shape:Solid
    Molecular weight:421.54
  • Cysteine protease inhibitor-2

    CAS:
    <p>Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.</p>
    Formula:C13H5N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:247.21
  • Kgp-IN-1

    CAS:
    <p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>
    Formula:C19H24F4N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:432.41
  • LHVS

    CAS:
    <p>LHVS effectively blocks T.</p>
    Formula:C28H37N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:527.68
  • CA 074

    CAS:
    <p>CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates</p>
    Formula:C18H29N3O6
    Purity:97.80%
    Color and Shape:Solid
    Molecular weight:383.44
  • Cathepsin X-IN-1

    CAS:
    <p>Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].</p>
    Formula:C15H13N3O3S
    Purity:99.34%
    Color and Shape:Solid
    Molecular weight:315.35
  • JNJ-10311795

    CAS:
    <p>JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.</p>
    Formula:C40H35N2O6P
    Purity:97.43%
    Color and Shape:Solid
    Molecular weight:670.69
  • SPR38


    <p>SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).</p>
    Formula:C24H33N3O5
    Color and Shape:Solid
    Molecular weight:443.54
  • Cathepsin K inhibitor 3

    CAS:
    <p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>
    Formula:C30H31FN4O4S
    Color and Shape:Solid
    Molecular weight:562.65
  • ABP 25

    CAS:
    <p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>
    Formula:C55H66ClN5O3
    Color and Shape:Solid
    Molecular weight:880.6
  • SQ 32056

    CAS:
    <p>SQ 32056 is a cathepsin E inhibitor.</p>
    Formula:C37H56N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:636.86
  • Cathepsin Inhibitor 2

    CAS:
    <p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: &lt;20 nM).</p>
    Formula:C19H21F6N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:421.38
  • MPI8

    CAS:
    <p>MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).</p>
    Formula:C32H48N4O7
    Color and Shape:Solid
    Molecular weight:600.75
  • Z-DEVD-CMK

    CAS:
    <p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>
    Formula:C27H35ClN4O12
    Color and Shape:Solid
    Molecular weight:643.04
  • Petesicatib

    CAS:
    <p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>
    Formula:C25H23F6N5O4S
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:603.54
  • MeOSuc-AAPV-CMK

    CAS:
    <p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>
    Formula:C22H35ClN4O7
    Color and Shape:Solid
    Molecular weight:502.99
  • Z-FG-NHO-BzOME

    CAS:
    <p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>
    Formula:C27H27N3O7
    Color and Shape:Solid
    Molecular weight:505.52
  • SID 26681509

    CAS:
    <p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>
    Formula:C27H33N5O5S
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:539.65
  • MK-0674

    CAS:
    <p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>
    Formula:C26H27F6N3O2
    Purity:97.3% - 99.91%
    Color and Shape:Solid
    Molecular weight:527.5
  • VBY-825

    CAS:
    <p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>
    Formula:C23H29F4N3O5S
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:535.55
  • GB111-NH2

    CAS:
    <p>GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].</p>
    Formula:C33H39N3O6
    Color and Shape:Solid
    Molecular weight:573.68
  • Verducatib

    CAS:
    <p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>
    Formula:C31H35FN4O3
    Color and Shape:Solid
    Molecular weight:530.633
  • Cathepsin K inhibitor 2

    CAS:
    <p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61
  • BI-1915

    CAS:
    <p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>
    Formula:C21H37N5O3
    Color and Shape:Solid
    Molecular weight:407.55
  • Cathepsin C-IN-3


    <p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>
    Formula:C28H21F3N6OS
    Color and Shape:Solid
    Molecular weight:546.57
  • RO5461111

    CAS:
    <p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) &amp; 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation &amp; lupus nephritis.</p>
    Formula:C27H24F6N4O4S
    Color and Shape:Solid
    Molecular weight:614.56
  • SID 26681509 quarterhydrate


    <p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>
    Formula:C27H35N5O6S
    Color and Shape:Solid
    Molecular weight:544.16
  • Dual Cathepsin L/JAK-IN-1

    CAS:
    <p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>
    Formula:C19H18ClN5
    Color and Shape:Solid
    Molecular weight:351.833
  • Cathepsin C-IN-5

    CAS:
    <p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>
    Formula:C21H17ClN6OS
    Color and Shape:Solid
    Molecular weight:436.92
  • Z-FY-CHO

    CAS:
    <p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>
    Formula:C26H26N2O5
    Purity:95.88%
    Color and Shape:Solid
    Molecular weight:446.5
  • CTSL/CAPN1-IN-2

    CAS:
    <p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>
    Formula:C34H40N4O6
    Color and Shape:Solid
    Molecular weight:600.7
  • CatD-IN-1

    CAS:
    <p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>
    Formula:C18H18Cl2N4O5
    Color and Shape:Solid
    Molecular weight:441.265
  • Cathepsin C-IN-4


    <p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>
    Formula:C21H14ClF3N4S
    Color and Shape:Solid
    Molecular weight:446.88
  • MIV-247

    CAS:
    <p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39
  • PD 151746

    CAS:
    <p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25
  • ALLM

    CAS:
    <p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product