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Glutaminase

Glutaminase

Glutaminase inhibitors are compounds that inhibit glutaminase, an enzyme that catalyzes the conversion of glutamine to glutamate, a critical step in cellular metabolism, especially in cancer cells. Glutaminase plays a key role in providing energy and biosynthetic precursors for rapidly proliferating cells. Inhibitors of glutaminase are important for exploring metabolic dependencies in cancer cells and developing potential therapeutic strategies. At CymitQuimica, we provide glutaminase inhibitors to support your research in cancer metabolism, cellular bioenergetics, and therapeutic discovery.

Found 46 products for "Glutaminase".

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  • 3-Aminobenzene-1,2-diol
    Targetmol
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    3-Aminobenzene-1,2-diol

    CAS:
    3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.
    Formula:C6H7NO2
    Color and Shape:Solid
    Molecular weight:125.13

    Ref: TM-T201595

    10mg
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    50mg
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  • TG-2-IN-4
    Targetmol
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    TG-2-IN-4

    CAS:
    TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].
    Formula:C34H40N6O5
    Color and Shape:Solid
    Molecular weight:612.72

    Ref: TM-T87508

    10mg
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    50mg
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  • Duazomycin sodium
    Targetmol
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    Duazomycin sodium

    CAS:
    Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.
    Formula:C8H10N3NaO4
    Color and Shape:Solid
    Molecular weight:235.17

    Ref: TM-T211286

    10mg
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    50mg
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  • TGase2-IN-1
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    TGase2-IN-1

    CAS:
    TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.
    Formula:C23H25N3O3
    Color and Shape:Solid
    Molecular weight:391.46

    Ref: TM-T201596

    10mg
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    50mg
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  • CymitQuimica logo
    Targetmol
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    GLS-1-IN-1

    GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.
    Formula:C26H25FN4OS
    Color and Shape:Solid
    Molecular weight:460.57

    Ref: TM-T62905

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • IPN60090 dihydrochloride
    Targetmol
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    IPN60090 dihydrochloride

    CAS:
    IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product