Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Found 63 products of "Gamma-secretase"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
CB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Formula:C15H18N2OPurity:99.44%Color and Shape:SolidMolecular weight:242.32Rovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Purity:> 95%Color and Shape:LiquidMolecular weight:145.02 kDaDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Purity:> 95%Color and Shape:LiquidMolecular weight:145.34 kDaBrontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Purity:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.93 kDaRovalpituzumab MMAE
Rovalpituzumab-MMAE (Anti-DLL3 Reference Antibody), produced in CHO cells, consists of a huIgG1 heavy chain and a hukappa light chain. The molecular weight of this antibody is predicted to be 145.02 kDa.Color and Shape:LiquidMolecular weight:145 kDaNavicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Color and Shape:LiquidJagged-1 (188-204)
CAS:Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Formula:C93H127N25O26S3Purity:98%Color and Shape:SolidMolecular weight:2107.4Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Formula:C64H98N15F3O25S3Purity:98%Color and Shape:SolidMolecular weight:1614.81PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Formula:C20H19ClF3NO3SColor and Shape:SolidMolecular weight:445.88SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Formula:C27H28FN5O4Purity:98%Color and Shape:SolidMolecular weight:505.545β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Formula:C24H40O2Purity:98.91% - 99.89%Color and Shape:SoildMolecular weight:360.57SAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Formula:C96H163N36F3O25SColor and Shape:SolidMolecular weight:2310.6RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFormula:C17H14FN3O2Purity:99.79%Color and Shape:SoildMolecular weight:311.31Ref: TM-T35566
1mg38.00€2mg50.00€5mg84.00€1mL*10mM (DMSO)93.00€10mg130.00€25mg215.00€50mg371.00€100mg537.00€PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Formula:C20H18ClFN2O3SColor and Shape:SolidMolecular weight:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Formula:C94H162N36O23SPurity:98%Color and Shape:SolidMolecular weight:2196.58CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formula:C17H19N3O2SPurity:99%Color and Shape:SolidMolecular weight:329.42γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Formula:C25H23F3N4O2Color and Shape:SolidMolecular weight:468.48FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFormula:C22H22ClN5O2Color and Shape:SolidMolecular weight:423.9Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Formula:C62H97N15O22S3Color and Shape:SolidMolecular weight:1500.72BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formula:C26H26F6N4O3Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:556.5
