Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Found 63 products of "Gamma-secretase"
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CB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Formula:C15H18N2OPurity:99.44%Color and Shape:SolidMolecular weight:242.32Brontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Purity:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.93 kDaDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Purity:> 95%Color and Shape:LiquidMolecular weight:145.34 kDaRovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Purity:> 95%Color and Shape:LiquidMolecular weight:145.02 kDaNavicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Color and Shape:LiquidRovalpituzumab MMAE
Rovalpituzumab-MMAE (Anti-DLL3 Reference Antibody), produced in CHO cells, consists of a huIgG1 heavy chain and a hukappa light chain. The molecular weight of this antibody is predicted to be 145.02 kDa.Color and Shape:LiquidMolecular weight:145 kDaSAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Formula:C96H163N36F3O25SColor and Shape:SolidMolecular weight:2310.6Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Formula:C62H97N15O22S3Color and Shape:SolidMolecular weight:1500.72PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Formula:C20H19ClF3NO3SColor and Shape:SolidMolecular weight:445.88SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Formula:C27H28FN5O4Purity:98%Color and Shape:SolidMolecular weight:505.54PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Formula:C20H18ClFN2O3SColor and Shape:SolidMolecular weight:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Formula:C94H162N36O23SPurity:98%Color and Shape:SolidMolecular weight:2196.58γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Formula:C25H23F3N4O2Color and Shape:SolidMolecular weight:468.48CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formula:C17H19N3O2SPurity:99%Color and Shape:SolidMolecular weight:329.42FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFormula:C22H22ClN5O2Color and Shape:SolidMolecular weight:423.9RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFormula:C17H14FN3O2Purity:99.79%Color and Shape:SoildMolecular weight:311.31Ref: TM-T35566
1mg38.00€2mg50.00€5mg84.00€1mL*10mM (DMSO)93.00€10mg130.00€25mg215.00€50mg371.00€100mg537.00€Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Formula:C64H98N15F3O25S3Purity:98%Color and Shape:SolidMolecular weight:1614.81BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formula:C26H26F6N4O3Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:556.55β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Formula:C24H40O2Purity:98.91% - 99.89%Color and Shape:SoildMolecular weight:360.57Jagged-1 (188-204)
CAS:Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Formula:C93H127N25O26S3Purity:98%Color and Shape:SolidMolecular weight:2107.4Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Formula:C23H25N5O4SPurity:98.14%Color and Shape:SolidMolecular weight:467.54Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Purity:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Color and Shape:LiquidMolecular weight:146.22 kDaγ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formula:C24H23FN4OSPurity:98%Color and Shape:SolidMolecular weight:434.53JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Formula:C23H24N2O3Purity:99.61%Color and Shape:SolidMolecular weight:376.45Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Formula:C95H128F3N25O28S3Purity:99.48%Color and Shape:SolidMolecular weight:2221.37IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C15H15NO5S2Purity:97.96% - 98.38%Color and Shape:SolidMolecular weight:353.41FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formula:C25H30N2O5Purity:99.81% - ≥98%Color and Shape:SolidMolecular weight:438.52Ref: TM-T3075
1mg34.00€2mg49.00€5mg71.00€1mL*10mM (DMSO)78.00€10mg94.00€25mg168.00€50mg295.00€100mg513.00€500mg1,125.00€γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Formula:C24H25ClN4OSPurity:98%Color and Shape:SolidMolecular weight:453MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formula:C21H21ClF2NaO4SColor and Shape:SolidMolecular weight:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purity:97.07%Color and Shape:SolidMolecular weight:409.48Ref: TM-T9015
1mg35.00€5mg80.00€1mL*10mM (DMSO)87.00€10mg112.00€25mg197.00€50mg290.00€100mg420.00€200mg590.00€RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formula:C25H28F3N7Purity:99.50%Color and Shape:SolidMolecular weight:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Formula:C20H14D3FO2SColor and Shape:SolidMolecular weight:343.43Tarextumab
CAS:Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.Purity:95%Color and Shape:LiquidMolecular weight:~150 kDaDilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Purity:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Color and Shape:LiquidMolecular weight:199.37 kDatCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Formula:C24H44O2Purity:98%Color and Shape:SolidMolecular weight:364.61LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Formula:C26H23F2N3O4Purity:98%Color and Shape:SolidMolecular weight:479.48ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Formula:C19H20BrClN2O3SPurity:98%Color and Shape:SolidMolecular weight:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Formula:C22H29N5O8Purity:98.80%Color and Shape:SolidMolecular weight:491.49Ref: TM-T12770
1mg152.00€5mg364.00€1mL*10mM (DMSO)394.00€10mg565.00€25mg1,044.00€50mg1,773.00€100mg2,602.00€ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formula:C19H20BrClN2O3SPurity:99.69%Color and Shape:SolidMolecular weight:471.8Ref: TM-T11178L
1mg154.00€5mg370.00€1mL*10mM (DMSO)424.00€10mg583.00€25mg858.00€50mg1,170.00€100mg1,575.00€Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Formula:C24H24N4O2Color and Shape:SolidMolecular weight:400.47BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Formula:C23H23FN6OColor and Shape:SolidMolecular weight:418.47JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formula:C22H24N2O3Purity:≥98% - ≥98.0%Color and Shape:SolidMolecular weight:364.44Aβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Formula:C29H26N4O2Purity:98%Color and Shape:SolidMolecular weight:462.54Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formula:C24H26N6O2Purity:98.09% - 99.87%Color and Shape:SolidMolecular weight:430.5Ref: TM-T9641
1mg39.00€1mL*10mM (DMSO)87.00€5mg89.00€10mg127.00€25mg203.00€50mg289.00€100mg399.00€200mg552.00€γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Formula:C25H22F4N6O2Purity:98%Color and Shape:SolidMolecular weight:514.47RR-11a
CAS:RR-11a is a synthetic enzyme Legumain inhibitor.
Formula:C24H28N6O10Purity:98%Color and Shape:SolidMolecular weight:560.51CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFormula:C17H20ClN3O2SPurity:99.02%Color and Shape:SolidMolecular weight:365.88γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Formula:C23H19FN4O2Purity:98%Color and Shape:SolidMolecular weight:402.42γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formula:C24H24N4OSPurity:99.75% - 99.96%Color and Shape:SolidMolecular weight:416.54γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFormula:C28H22F2N4O2Color and Shape:SolidMolecular weight:484.5
