Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
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CIA-1 hcl(452087-38-6 Free base)
CAS:1049691-47-5
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM …
Formula:
C17H20ClN3O2S
Purity:
99.02%
Color and Shape:
Liquid
Molecular weight:
365.88
Ref: TM-T71534
| 10mg | 373.00 € | ||
| 50mg | 1,556.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Aβ42-IN-2
CAS:1914989-80-2
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ …
Formula:
C24H26N6O2
Purity:
100% - 99.49%
Color and Shape:
Liquid
Molecular weight:
430.5
Ref: TM-T9641
| 1mg | 63.00 € | ||
| 2mg | 92.00 € | ||
| 5mg | 138.00 € | ||
| 10mg | 211.00 € | ||
| 25mg | 351.00 € | ||
| 50mg | 498.00 € | ||
| 100mg | 687.00 € | ||
| 500mg | 1,377.00 € | ||
| 1mL*10mM (DMSO) | 154.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
JI051
CAS:2234281-75-3
JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 …
Formula:
C22H24N2O3
Purity:
≥98% - ≥98.0%
Color and Shape:
Solid
Molecular weight:
364.44
Ref: TM-T11718
| 1mg | 64.00 € | ||
| 2mg | 90.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
BMS-983970
CAS:1584713-87-0
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
Formula:
C26H26F4N4O3
Color and Shape:
Solid
Molecular weight:
518.5
Ref: TM-T14683
| 2mg | 186.00 € | ||
| 5mg | 325.00 € | ||
| 25mg | 1,410.00 € | ||
| 50mg | 1,854.00 € | ||
| 100mg | 1,863.00 € | ||
| 1mL*10mM (DMSO) | 374.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
HDAC6-IN-9
CAS:2796282-58-9
HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse …
Formula:
C19H16N2O3
Color and Shape:
Liquid
Molecular weight:
320.34
Ref: TM-T60856
| 1mg | 267.00 € | ||
| 5mg | 657.00 € | ||
| 10mg | 898.00 € | ||
| 25mg | 1,437.00 € | ||
| 50mg | 1,872.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
